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Q2YR40

- XERD_BRUA2

UniProt

Q2YR40 - XERD_BRUA2

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Protein

Tyrosine recombinase XerD

Gene

xerD

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581By similarity
Active sitei182 – 1821By similarity
Active sitei254 – 2541By similarity
Active sitei257 – 2571By similarity
Active sitei280 – 2801By similarity
Active sitei289 – 2891O-(3'-phospho-DNA)-tyrosine intermediateBy similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. tyrosine-based site-specific recombinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome segregation Source: UniProtKB-HAMAP
  4. transposition, DNA-mediated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, DNA integration, DNA recombination

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2085-MONOMER.
BMEL359391:GJOQ-2085-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine recombinase XerD
Gene namesi
Name:xerD
Ordered Locus Names:BAB1_2032
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Tyrosine recombinase XerDPRO_0000095375Add
BLAST

Expressioni

Inductioni

It is induced 4 hours after macrophage infection.1 Publication

Interactioni

Subunit structurei

Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.By similarity

Protein-protein interaction databases

STRINGi359391.BAB1_2032.

Structurei

3D structure databases

ProteinModelPortaliQ2YR40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4974.
HOGENOMiHOG000045296.
KOiK04763.
OrthoDBiEOG6PZXFP.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPiMF_01807. Recomb_XerD.
MF_01808. Recomb_XerC.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR011932. Recomb_XerD.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamiPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 1 hit.
TIGRFAMsiTIGR02225. recomb_XerD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YR40-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMRASLAIE NFLEMMSAER GAAQNTLESY RRDLEAAAEE LAAKGVNLAE
60 70 80 90 100
AETGHIRMTL DTMAAQGFAP TSQARRLSAL RQFFRFLYSE GFRQDDPTGI
110 120 130 140 150
LYAPKKQKPL PKIMSVENVG KLLDRAALEA NEAAEPGERI KALRLHALLE
160 170 180 190 200
TLYATGLRVS ELVGLPVTVA RTDHRFLLVR GKGSKDRMVP LSRKARDALQ
210 220 230 240 250
KFLTLRDSLP GSDDNPWLFP AFSESGHLAR QVFARELKGL AARAGLAASS
260 270 280 290 300
ASPHVLRHAF ASHLLQNGAD LRTVQQLLGH ADISTTQIYT HVLEERLHKL

VSEHHPLAD
Length:309
Mass (Da):34,130
Last modified:February 7, 2006 - v2
Checksum:iB24287E577CEDC33
GO

Sequence cautioni

The sequence CAJ11988.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11988.1. Different initiation.
AF279676 Genomic DNA. Translation: AAG01447.1.
RefSeqiYP_415362.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ11988; CAJ11988; BAB1_2032.
GeneIDi3788483.
KEGGibmf:BAB1_2032.
PATRICi17847155. VBIBruMel86222_2114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11988.1 . Different initiation.
AF279676 Genomic DNA. Translation: AAG01447.1 .
RefSeqi YP_415362.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YR40.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_2032.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ11988 ; CAJ11988 ; BAB1_2032 .
GeneIDi 3788483.
KEGGi bmf:BAB1_2032.
PATRICi 17847155. VBIBruMel86222_2114.

Phylogenomic databases

eggNOGi COG4974.
HOGENOMi HOG000045296.
KOi K04763.
OrthoDBi EOG6PZXFP.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-2085-MONOMER.
BMEL359391:GJOQ-2085-MONOMER.

Miscellaneous databases

PROi Q2YR40.

Family and domain databases

Gene3Di 1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPi MF_01807. Recomb_XerD.
MF_01808. Recomb_XerC.
InterProi IPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR011932. Recomb_XerD.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view ]
Pfami PF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view ]
SUPFAMi SSF56349. SSF56349. 1 hit.
TIGRFAMsi TIGR02225. recomb_XerD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.
  2. "Brucella abortus genes identified following constitutive growth and macrophage infection."
    Eskra L., Canavessi A., Carey M., Splitter G.A.
    Infect. Immun. 69:7736-7742(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-95, INDUCTION.

Entry informationi

Entry nameiXERD_BRUA2
AccessioniPrimary (citable) accession number: Q2YR40
Secondary accession number(s): Q57AM6, Q9FDG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: October 29, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3