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Q2YR40 (XERD_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine recombinase XerD
Gene names
Name:xerD
Ordered Locus Names:BAB1_2032
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids By similarity. HAMAP-Rule MF_01807

Subunit structure

Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01807.

Induction

It is induced 4 hours after macrophage infection. Ref.2

Sequence similarities

Belongs to the 'phage' integrase family. XerD subfamily.

Sequence caution

The sequence CAJ11988.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Tyrosine recombinase XerD HAMAP-Rule MF_01807
PRO_0000095375

Sites

Active site1581 By similarity
Active site1821 By similarity
Active site2541 By similarity
Active site2571 By similarity
Active site2801 By similarity
Active site2891O-(3'-phospho-DNA)-tyrosine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YR40 [UniParc].

Last modified February 7, 2006. Version 2.
Checksum: B24287E577CEDC33

FASTA30934,130
        10         20         30         40         50         60 
MTMRASLAIE NFLEMMSAER GAAQNTLESY RRDLEAAAEE LAAKGVNLAE AETGHIRMTL 

        70         80         90        100        110        120 
DTMAAQGFAP TSQARRLSAL RQFFRFLYSE GFRQDDPTGI LYAPKKQKPL PKIMSVENVG 

       130        140        150        160        170        180 
KLLDRAALEA NEAAEPGERI KALRLHALLE TLYATGLRVS ELVGLPVTVA RTDHRFLLVR 

       190        200        210        220        230        240 
GKGSKDRMVP LSRKARDALQ KFLTLRDSLP GSDDNPWLFP AFSESGHLAR QVFARELKGL 

       250        260        270        280        290        300 
AARAGLAASS ASPHVLRHAF ASHLLQNGAD LRTVQQLLGH ADISTTQIYT HVLEERLHKL 


VSEHHPLAD 

« Hide

References

« Hide 'large scale' references
[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.
[2]"Brucella abortus genes identified following constitutive growth and macrophage infection."
Eskra L., Canavessi A., Carey M., Splitter G.A.
Infect. Immun. 69:7736-7742(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-95, INDUCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ11988.1. Different initiation.
AF279676 Genomic DNA. Translation: AAG01447.1.
RefSeqYP_415362.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YR40.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_2032.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ11988; CAJ11988; BAB1_2032.
GeneID3788483.
KEGGbmf:BAB1_2032.
PATRIC17847155. VBIBruMel86222_2114.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4974.
HOGENOMHOG000045296.
KOK04763.
OrthoDBEOG6PZXFP.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2085-MONOMER.
BMEL359391:GJOQ-2085-MONOMER.

Family and domain databases

Gene3D1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
HAMAPMF_01807. Recomb_XerD.
MF_01808. Recomb_XerC.
InterProIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat-core.
IPR002104. Integrase_catalytic.
IPR023109. Integrase_recombinase_N.
IPR004107. Integrase_SAM-like_N.
IPR011932. Recomb_XerD.
IPR023009. Tyrosine_recombinase_XerC/XerD.
[Graphical view]
PfamPF02899. Phage_int_SAM_1. 1 hit.
PF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMSSF56349. SSF56349. 1 hit.
TIGRFAMsTIGR02225. recomb_XerD. 1 hit.
ProtoNetSearch...

Other

PROQ2YR40.

Entry information

Entry nameXERD_BRUA2
AccessionPrimary (citable) accession number: Q2YR40
Secondary accession number(s): Q57AM6, Q9FDG0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names