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Q2YR04 (AROE_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Shikimate dehydrogenase

EC=1.1.1.25
Gene names
Name:aroE
Ordered Locus Names:BAB1_2070
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP-Rule MF_00222

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP-Rule MF_00222

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Sequence caution

The sequence CAJ12026.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Shikimate dehydrogenase HAMAP-Rule MF_00222
PRO_0000325109

Regions

Nucleotide binding134 – 1385NADP By similarity

Sites

Active site731Proton acceptor Potential

Sequences

Sequence LengthMass (Da)Tools
Q2YR04 [UniParc].

Last modified March 18, 2008. Version 2.
Checksum: B1B17A56EED18496

FASTA28930,520
        10         20         30         40         50         60 
MDDKSMARGR KAFVTGFPIR HSRSPLIHGF WLKELGIDGS YEAVEVKPED FSSFAASLAA 

        70         80         90        100        110        120 
NGFAGGNVTI PHKEAAYAAA ESLDEAARAI GAVNTLWLEN GRLCGGNTDA YGFAANLDAS 

       130        140        150        160        170        180 
APGWDKADRA LVLGAGGASR AVVHALLSRG VCHVSVVNRT LSRAEELAAH FGARVYAHSW 

       190        200        210        220        230        240 
DEAQALVSNA GLIVNTTALG MSGHGEGQDF PIDLTCAPKE AVATDIVYVP LRTAFLNKAE 

       250        260        270        280 
KAGLKTVDGL GMLLHQAVPG FERWFGQRPQ VTQALREHIL ADMAKAGAL 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ12026.1. Different initiation.
RefSeqYP_415398.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YR04.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_2070.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ12026; CAJ12026; BAB1_2070.
GeneID3788516.
KEGGbmf:BAB1_2070.
PATRIC17847235. VBIBruMel86222_2153.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0169.
HOGENOMHOG000237876.
KOK00014.
OrthoDBEOG64R67G.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2124-MONOMER.
BMEL359391:GJOQ-2124-MONOMER.
UniPathwayUPA00053; UER00087.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00222. Shikimate_DH_AroE.
InterProIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
PfamPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00507. aroE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROE_BRUA2
AccessionPrimary (citable) accession number: Q2YR04
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 14, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names