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Q2YR04

- AROE_BRUA2

UniProt

Q2YR04 - AROE_BRUA2

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Protein
Shikimate dehydrogenase
Gene
aroE, BAB1_2070
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Shikimate + NADP+ = 3-dehydroshikimate + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Proton acceptor Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi134 – 1385NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
  3. shikimate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2124-MONOMER.
BMEL359391:GJOQ-2124-MONOMER.
UniPathwayiUPA00053; UER00087.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate dehydrogenase (EC:1.1.1.25)
Gene namesi
Name:aroE
Ordered Locus Names:BAB1_2070
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Shikimate dehydrogenaseUniRule annotation
PRO_0000325109Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_2070.

Structurei

3D structure databases

ProteinModelPortaliQ2YR04.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0169.
HOGENOMiHOG000237876.
KOiK00014.
OrthoDBiEOG64R67G.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00222. Shikimate_DH_AroE.
InterProiIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
PfamiPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00507. aroE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YR04-1 [UniParc]FASTAAdd to Basket

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MDDKSMARGR KAFVTGFPIR HSRSPLIHGF WLKELGIDGS YEAVEVKPED    50
FSSFAASLAA NGFAGGNVTI PHKEAAYAAA ESLDEAARAI GAVNTLWLEN 100
GRLCGGNTDA YGFAANLDAS APGWDKADRA LVLGAGGASR AVVHALLSRG 150
VCHVSVVNRT LSRAEELAAH FGARVYAHSW DEAQALVSNA GLIVNTTALG 200
MSGHGEGQDF PIDLTCAPKE AVATDIVYVP LRTAFLNKAE KAGLKTVDGL 250
GMLLHQAVPG FERWFGQRPQ VTQALREHIL ADMAKAGAL 289
Length:289
Mass (Da):30,520
Last modified:March 18, 2008 - v2
Checksum:iB1B17A56EED18496
GO

Sequence cautioni

The sequence CAJ12026.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ12026.1. Different initiation.
RefSeqiYP_415398.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ12026; CAJ12026; BAB1_2070.
GeneIDi3788516.
KEGGibmf:BAB1_2070.
PATRICi17847235. VBIBruMel86222_2153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ12026.1 . Different initiation.
RefSeqi YP_415398.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YR04.
ModBasei Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_2070.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ12026 ; CAJ12026 ; BAB1_2070 .
GeneIDi 3788516.
KEGGi bmf:BAB1_2070.
PATRICi 17847235. VBIBruMel86222_2153.

Phylogenomic databases

eggNOGi COG0169.
HOGENOMi HOG000237876.
KOi K00014.
OrthoDBi EOG64R67G.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00087 .
BioCyci BABO359391:GKDV-2124-MONOMER.
BMEL359391:GJOQ-2124-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00222. Shikimate_DH_AroE.
InterProi IPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view ]
Pfami PF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00507. aroE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiAROE_BRUA2
AccessioniPrimary (citable) accession number: Q2YR04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 14, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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