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Q2YR04

- AROE_BRUA2

UniProt

Q2YR04 - AROE_BRUA2

Protein

Shikimate dehydrogenase

Gene

aroE

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Shikimate + NADP+ = 3-dehydroshikimate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi134 – 1385NADPUniRule annotation

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway
    3. shikimate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2124-MONOMER.
    BMEL359391:GJOQ-2124-MONOMER.
    UniPathwayiUPA00053; UER00087.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Shikimate dehydrogenaseUniRule annotation (EC:1.1.1.25UniRule annotation)
    Gene namesi
    Name:aroEUniRule annotation
    Ordered Locus Names:BAB1_2070
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Shikimate dehydrogenasePRO_0000325109Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB1_2070.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YR04.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the shikimate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0169.
    HOGENOMiHOG000237876.
    KOiK00014.
    OrthoDBiEOG64R67G.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00222. Shikimate_DH_AroE.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR011342. Shikimate_DH.
    IPR013708. Shikimate_DH-bd_N.
    IPR022893. Shikimate_quinate_DH.
    IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
    [Graphical view]
    PfamiPF01488. Shikimate_DH. 1 hit.
    PF08501. Shikimate_dh_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00507. aroE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YR04-1 [UniParc]FASTAAdd to Basket

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    MDDKSMARGR KAFVTGFPIR HSRSPLIHGF WLKELGIDGS YEAVEVKPED    50
    FSSFAASLAA NGFAGGNVTI PHKEAAYAAA ESLDEAARAI GAVNTLWLEN 100
    GRLCGGNTDA YGFAANLDAS APGWDKADRA LVLGAGGASR AVVHALLSRG 150
    VCHVSVVNRT LSRAEELAAH FGARVYAHSW DEAQALVSNA GLIVNTTALG 200
    MSGHGEGQDF PIDLTCAPKE AVATDIVYVP LRTAFLNKAE KAGLKTVDGL 250
    GMLLHQAVPG FERWFGQRPQ VTQALREHIL ADMAKAGAL 289
    Length:289
    Mass (Da):30,520
    Last modified:March 18, 2008 - v2
    Checksum:iB1B17A56EED18496
    GO

    Sequence cautioni

    The sequence CAJ12026.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ12026.1. Different initiation.
    RefSeqiYP_415398.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ12026; CAJ12026; BAB1_2070.
    GeneIDi3788516.
    KEGGibmf:BAB1_2070.
    PATRICi17847235. VBIBruMel86222_2153.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ12026.1 . Different initiation.
    RefSeqi YP_415398.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YR04.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_2070.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ12026 ; CAJ12026 ; BAB1_2070 .
    GeneIDi 3788516.
    KEGGi bmf:BAB1_2070.
    PATRICi 17847235. VBIBruMel86222_2153.

    Phylogenomic databases

    eggNOGi COG0169.
    HOGENOMi HOG000237876.
    KOi K00014.
    OrthoDBi EOG64R67G.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00087 .
    BioCyci BABO359391:GKDV-2124-MONOMER.
    BMEL359391:GJOQ-2124-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00222. Shikimate_DH_AroE.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR011342. Shikimate_DH.
    IPR013708. Shikimate_DH-bd_N.
    IPR022893. Shikimate_quinate_DH.
    IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
    [Graphical view ]
    Pfami PF01488. Shikimate_DH. 1 hit.
    PF08501. Shikimate_dh_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00507. aroE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiAROE_BRUA2
    AccessioniPrimary (citable) accession number: Q2YR04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3