Reviewed,
UniProtKB/Swiss-Prot Q2YR04 (AROE_BRUA2)
Last modified
February 9, 2010.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Shikimate dehydrogenase EC=1.1.1.25 | ||||
| Gene names |
| ||||
| Organism | Brucella abortus (strain 2308) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 359391 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 289 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222 |
| Pathway | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222 |
| Sequence similarities | Belongs to the shikimate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Aromatic amino acid biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: InterPro |
| Molecular function | NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 289 | 289 | Shikimate dehydrogenase HAMAP MF_00222 | PRO_0000325109 | |||||
Regions | |||||||||
| Nucleotide binding | 134 – 138 | 5 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 73 | 1 | Proton acceptor Potential | ||||||
Sequences
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References
| [1] | "Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AM040264 Genomic DNA. Translation: CAJ12026.1. Different initiation. |
| RefSeq | YP_415398.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2GPT based on UniProtKB Q9SQT8. |
| SMR | Q2YR04. Positions 11-278. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2YR04. |
Genome annotation databases | |
| GeneID | 3788516. |
| GenomeReviews | Gene locus BAB1_2070 in contig AM040264_GR. |
| KEGG | bmf:BAB1_2070. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0169. |
| HOGENOM | HBG553408. |
Enzyme and pathway databases | |
| BioCyc | BMEL359391:BAB1_2070-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00222. Shikimate_DH_AroE. [Tree] |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00507. aroE. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | AROE_BRUA2 | ||||||||
| Accession | Primary (citable) accession number: Q2YR04 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Brucella abortus strain 2308 Brucella abortus (strain 2308): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


