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Q2YQY6 (COAA_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pantothenate kinase

EC=2.7.1.33
Alternative name(s):
Pantothenic acid kinase
Gene names
Name:coaA
Ordered Locus Names:BAB1_2088
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP-Rule MF_00215

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP-Rule MF_00215

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00215.

Sequence similarities

Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
   Biological processCoenzyme A biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcoenzyme A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pantothenate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Pantothenate kinase HAMAP-Rule MF_00215
PRO_1000043213

Regions

Nucleotide binding100 – 1078ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q2YQY6 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: D3EFE627DD4C7D0B

FASTA32237,495
        10         20         30         40         50         60 
MWEKVDQLTP SRYSPYRFFS AQEWAAFRAD TPLTLTYEEV KRLRSLGDPI DLDEVRRIYL 

        70         80         90        100        110        120 
SLSRLLYAHV EASQLLFRQR QQFLNMEESY KTPFIIGVAG SVAVGKSTMA RILKELLARW 

       130        140        150        160        170        180 
PSSPKVDLVT TDGFLYPNAV LREQNMMERK GFPESYDIGA VLRFLSAIKA GMSRVRAPLY 

       190        200        210        220        230        240 
SHLSYDVLPG EYQIVDKPDI LIFEGINVLQ VRDLPEDGKM VPFVSDFFDF SIYIDADPRL 

       250        260        270        280        290        300 
IHKWYIDRFM RLRETAFRDP QSFFHRYSQL SQEAARSIAE GLWQNINMKN LNENILPTRP 

       310        320 
RADLILRKGS DHLIEEVALR KI 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ12044.1.
RefSeqYP_415416.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YQY6.
SMRQ2YQY6. Positions 12-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_2088.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ12044; CAJ12044; BAB1_2088.
GeneID3788656.
KEGGbmf:BAB1_2088.
PATRIC17847275. VBIBruMel86222_2173.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1072.
HOGENOMHOG000248571.
KOK00867.
OMAFNRSQWA.
OrthoDBEOG62C9GX.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2142-MONOMER.
BMEL359391:GJOQ-2142-MONOMER.
UniPathwayUPA00241; UER00352.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00215. Pantothen_kinase_1.
InterProIPR027417. P-loop_NTPase.
IPR004566. PanK_bact.
IPR006083. PRK/URK.
[Graphical view]
PANTHERPTHR10285:SF7. PTHR10285:SF7. 1 hit.
PfamPF00485. PRK. 1 hit.
[Graphical view]
PIRSFPIRSF000545. Pantothenate_kin. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00554. panK_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOAA_BRUA2
AccessionPrimary (citable) accession number: Q2YQY6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names