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Q2YQW7 (TRPA_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan synthase alpha chain

EC=4.2.1.20
Gene names
Name:trpA
Ordered Locus Names:BAB1_2110
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate By similarity. HAMAP-Rule MF_00131

Catalytic activity

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00131

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00131

Subunit structure

Tetramer of two alpha and two beta chains By similarity.

Sequence similarities

Belongs to the TrpA family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functiontryptophan synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Tryptophan synthase alpha chain HAMAP-Rule MF_00131
PRO_1000018171

Sites

Active site501Proton acceptor By similarity
Active site611Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YQW7 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 060A1B62992AE789

FASTA27929,486
        10         20         30         40         50         60 
MTTRIDTKFA ELKAEGRPAL VTYFMGGDPD LETALKVMKA LPKAGADVIE LGMPFSDPMA 

        70         80         90        100        110        120 
DGPAIQAAGL RALNAGQTLA KTLYMAAEFR KEDDTTPIVM MGYYNPIYVY GVERFLTDAK 

       130        140        150        160        170        180 
ASGVDGLIVV DLPSEMDAEL CIPAMKAGIN FIRLTTPTTD DKRLPKVLHN SSGFVYYVSM 

       190        200        210        220        230        240 
NGITGAAIAD TAKVGEAVRH IKKSTDLPIC VGFGVKTPEQ AAAIATHADS VVVGTAIVNA 

       250        260        270 
IAGELDEKGK VKGDPVAAAT RLVHALAESV RATRLEAAQ 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ12066.1.
RefSeqYP_415435.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YQW7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_2110.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ12066; CAJ12066; BAB1_2110.
GeneID3789035.
KEGGbmf:BAB1_2110.
PATRIC17847319. VBIBruMel86222_2195.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0159.
HOGENOMHOG000223815.
KOK01695.
OMAATTEHVT.
OrthoDBEOG6RVG0K.
ProtClustDBPRK13111.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2164-MONOMER.
BMEL359391:GJOQ-2164-MONOMER.
UniPathwayUPA00035; UER00044.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00131. Trp_synth_alpha.
InterProIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR00262. trpA. 1 hit.
PROSITEPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPA_BRUA2
AccessionPrimary (citable) accession number: Q2YQW7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names