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Q2YQW7

- TRPA_BRUA2

UniProt

Q2YQW7 - TRPA_BRUA2

Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

    Catalytic activityi

    L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei50 – 501Proton acceptorUniRule annotation
    Active sitei61 – 611Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. tryptophan synthase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2164-MONOMER.
    BMEL359391:GJOQ-2164-MONOMER.
    UniPathwayiUPA00035; UER00044.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
    Gene namesi
    Name:trpAUniRule annotation
    Ordered Locus Names:BAB1_2110
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Tryptophan synthase alpha chainPRO_1000018171Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_2110.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YQW7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0159.
    HOGENOMiHOG000223815.
    KOiK01695.
    OMAiDPGYDTS.
    OrthoDBiEOG6RVG0K.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00131. Trp_synth_alpha.
    InterProiIPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR018204. Trp_synthase_alpha_AS.
    IPR002028. Trp_synthase_suA.
    [Graphical view]
    PfamiPF00290. Trp_syntA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR00262. trpA. 1 hit.
    PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YQW7-1 [UniParc]FASTAAdd to Basket

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    MTTRIDTKFA ELKAEGRPAL VTYFMGGDPD LETALKVMKA LPKAGADVIE    50
    LGMPFSDPMA DGPAIQAAGL RALNAGQTLA KTLYMAAEFR KEDDTTPIVM 100
    MGYYNPIYVY GVERFLTDAK ASGVDGLIVV DLPSEMDAEL CIPAMKAGIN 150
    FIRLTTPTTD DKRLPKVLHN SSGFVYYVSM NGITGAAIAD TAKVGEAVRH 200
    IKKSTDLPIC VGFGVKTPEQ AAAIATHADS VVVGTAIVNA IAGELDEKGK 250
    VKGDPVAAAT RLVHALAESV RATRLEAAQ 279
    Length:279
    Mass (Da):29,486
    Last modified:December 20, 2005 - v1
    Checksum:i060A1B62992AE789
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ12066.1.
    RefSeqiYP_415435.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ12066; CAJ12066; BAB1_2110.
    GeneIDi3789035.
    KEGGibmf:BAB1_2110.
    PATRICi17847319. VBIBruMel86222_2195.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ12066.1 .
    RefSeqi YP_415435.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YQW7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_2110.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ12066 ; CAJ12066 ; BAB1_2110 .
    GeneIDi 3789035.
    KEGGi bmf:BAB1_2110.
    PATRICi 17847319. VBIBruMel86222_2195.

    Phylogenomic databases

    eggNOGi COG0159.
    HOGENOMi HOG000223815.
    KOi K01695.
    OMAi DPGYDTS.
    OrthoDBi EOG6RVG0K.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00044 .
    BioCyci BABO359391:GKDV-2164-MONOMER.
    BMEL359391:GJOQ-2164-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00131. Trp_synth_alpha.
    InterProi IPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR018204. Trp_synthase_alpha_AS.
    IPR002028. Trp_synthase_suA.
    [Graphical view ]
    Pfami PF00290. Trp_syntA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR00262. trpA. 1 hit.
    PROSITEi PS00167. TRP_SYNTHASE_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiTRPA_BRUA2
    AccessioniPrimary (citable) accession number: Q2YQW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3