Reviewed,
UniProtKB/Swiss-Prot Q2YQV5 (SYFA_BRUA2)
Last modified
February 9, 2010.
Version 26.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Phenylalanyl-tRNA synthetase alpha chain EC=6.1.1.20 Alternative name(s): Phenylalanine--tRNA ligase alpha chain Short name=PheRS | ||||
| Gene names |
| ||||
| Organism | Brucella abortus (strain 2308) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 359391 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 369 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). HAMAP MF_00281 |
| Cofactor | Binds 2 magnesium ions per tetramer By similarity. HAMAP MF_00281 |
| Subunit structure | Tetramer of two alpha and two beta chains By similarity. HAMAP MF_00281 |
| Subcellular location | |
| Sequence similarities | Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Aminoacyl-tRNA synthetase Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | phenylalanyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion bindingInferred from electronic annotation. Source: HAMAP phenylalanine-tRNA ligase activityInferred from electronic annotation. Source: HAMAP tRNA bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 369 | 369 | Phenylalanyl-tRNA synthetase alpha chain HAMAP MF_00281 | PRO_0000231968 | |||||
Sites | |||||||||
| Metal binding | 269 | 1 | Magnesium By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AM040264 Genomic DNA. Translation: CAJ12082.1. |
| RefSeq | YP_415447.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2YQV5. |
Genome annotation databases | |
| GeneID | 3788851. |
| GenomeReviews | Gene locus BAB1_2126 in contig AM040264_GR. |
| KEGG | bmf:BAB1_2126. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0016. |
| HOGENOM | HBG284353. |
| OMA | FRASYFP. |
Enzyme and pathway databases | |
| BioCyc | BMEL359391:BAB1_2126-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00281. Phe_tRNA_synth_alpha1. [Tree] |
| InterPro | IPR006195. aa-tRNA-synth_II_cons-dom. IPR004529. Phe-tRNA-synth_IIc_asu. IPR004188. Phe-tRNA_synth_II_N. IPR002319. Phenylalanyl-tRNA_Synthase_acu. IPR010978. tRNA_bd_arm. [Graphical view] |
| PANTHER | PTHR11538. tRNA-synt_2d. 1 hit. |
| Pfam | PF02912. Phe_tRNA-synt_N. 1 hit. PF01409. tRNA-synt_2d. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00468. pheS. 1 hit. |
| PROSITE | PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SYFA_BRUA2 | ||||||||
| Accession | Primary (citable) accession number: Q2YQV5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Aminoacyl-tRNA synthetases List of aminoacyl-tRNA synthetase entries |
| Brucella abortus strain 2308 Brucella abortus (strain 2308): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


