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Q2YQV4

- SYFB_BRUA2

UniProt

Q2YQV4 - SYFB_BRUA2

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Protein
Phenylalanine--tRNA ligase beta subunit
Gene
pheT, BAB1_2127
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

Cofactori

Binds 2 magnesium ions per tetramer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi454 – 4541Magnesium By similarity
Metal bindingi460 – 4601Magnesium; via carbonyl oxygen By similarity
Metal bindingi463 – 4631Magnesium By similarity
Metal bindingi464 – 4641Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
  4. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
  2. tRNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, RNA-binding, tRNA-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2181-MONOMER.
BMEL359391:GJOQ-2181-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunit (EC:6.1.1.20)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunit
Short name:
PheRS
Gene namesi
Name:pheT
Ordered Locus Names:BAB1_2127
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Phenylalanine--tRNA ligase beta subunitUniRule annotation
PRO_0000232048Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi359391.BAB1_2127.

Structurei

3D structure databases

ProteinModelPortaliQ2YQV4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 148111tRNA-binding
Add
BLAST
Domaini401 – 47676B5
Add
BLAST
Domaini710 – 80394FDX-ACB
Add
BLAST

Sequence similaritiesi

Contains 1 B5 domain.
Contains 1 FDX-ACB domain.

Phylogenomic databases

eggNOGiCOG0073.
HOGENOMiHOG000292085.
KOiK01890.
OMAiRTSCDET.
OrthoDBiEOG6CCH1J.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.30.56.20. 1 hit.
3.30.70.380. 1 hit.
3.50.40.10. 1 hit.
HAMAPiMF_00283. Phe_tRNA_synth_beta1.
InterProiIPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR012340. NA-bd_OB-fold.
IPR004532. Phe-tRNA-ligase_IIc_bsu.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR005121. PheS_beta_Fdx_antiC-bd.
IPR002547. tRNA-bd_dom.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view]
PfamiPF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF03147. FDX-ACB. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view]
SMARTiSM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
SM00896. FDX-ACB. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54991. SSF54991. 1 hit.
SSF56037. SSF56037. 1 hit.
TIGRFAMsiTIGR00472. pheT_bact. 1 hit.
PROSITEiPS51483. B5. 1 hit.
PS51447. FDX_ACB. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YQV4-1 [UniParc]FASTAAdd to Basket

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MKFTLSWLKD HLETDATLDE IVEKLTDIGL EVESVDDRAA FRAFTIARVL    50
TATRHPDADK LQVLSVDTGD GKPVQVVCGA PNARAGLVGV LGRPGDYVPG 100
LDVTLSVGKI RGVESFGMMC SERELELSDE HNGIIDLAEN APVGTSFAAY 150
MGLDDPIIEI GLTPNRADCT GIRGIARDLA AAGLGTLKNT LPDAVKGEGE 200
TPVKVILDQD AGNPFCTGFA LRMVKGVKNG PSPKWMQQRL KAIGLRPINA 250
LVDITNYVTF DQGRPLHVFD AAKVKGNLTV RTARDGETIL ALDQREYKLN 300
AGMYVIADEN GPESIAGIMG GEHSGCDENT VDVLIESALW DPRMIASTGR 350
ELGIVTDARY RFERGVDPEM MVPGAEIATK LVLELCGGQP TVLDVVGYKP 400
HTARVIDFPV TEVKRLTGLD VSYEDAFDIL KRLGFGVEGD GKTIRATVPS 450
WRGDVEGKAD LVEEVMRIHG INRIDPQPLP SHGAVNGRIL TTLQIRTRHA 500
RRMLASRGMM EAVTYSFISE AQAKAFGGGK PELKLANPIA ADMSDMRPSL 550
LPGLLAAAQR NADRGFDDIA LFEVSGIYEG DTPDKQRRVA GGVRRGTAKV 600
EGAGRFWAGN AAPVGVFDAK ADALAALEAA GAPVDRIQIE AGGPEWLHPG 650
RSGTLKLGPK VVLGTFGEFH PDTLEALDVS GALCGFEVYL DAIPEPKAKS 700
ARTKPALSLS LFQSLKRDYA FVVDAAVEAG NVVKAVSSAD KKLIVGVQVF 750
DIFTGASLGE GKKSIAVEVL LQPQDRTLTD EDLEALSKQI VASVAKQTGG 800
VLRG 804
Length:804
Mass (Da):85,838
Last modified:February 7, 2006 - v1
Checksum:iEABC1EC1A8230AA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ12083.1.
RefSeqiYP_415448.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ12083; CAJ12083; BAB1_2127.
GeneIDi3788852.
KEGGibmf:BAB1_2127.
PATRICi17847353. VBIBruMel86222_2212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ12083.1 .
RefSeqi YP_415448.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YQV4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_2127.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ12083 ; CAJ12083 ; BAB1_2127 .
GeneIDi 3788852.
KEGGi bmf:BAB1_2127.
PATRICi 17847353. VBIBruMel86222_2212.

Phylogenomic databases

eggNOGi COG0073.
HOGENOMi HOG000292085.
KOi K01890.
OMAi RTSCDET.
OrthoDBi EOG6CCH1J.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-2181-MONOMER.
BMEL359391:GJOQ-2181-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.30.56.20. 1 hit.
3.30.70.380. 1 hit.
3.50.40.10. 1 hit.
HAMAPi MF_00283. Phe_tRNA_synth_beta1.
InterProi IPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR012340. NA-bd_OB-fold.
IPR004532. Phe-tRNA-ligase_IIc_bsu.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR005121. PheS_beta_Fdx_antiC-bd.
IPR002547. tRNA-bd_dom.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view ]
Pfami PF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF03147. FDX-ACB. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view ]
SMARTi SM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
SM00896. FDX-ACB. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54991. SSF54991. 1 hit.
SSF56037. SSF56037. 1 hit.
TIGRFAMsi TIGR00472. pheT_bact. 1 hit.
PROSITEi PS51483. B5. 1 hit.
PS51447. FDX_ACB. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiSYFB_BRUA2
AccessioniPrimary (citable) accession number: Q2YQV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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