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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi466 – 4738GTPUniRule annotation
Nucleotide bindingi512 – 5165GTPUniRule annotation
Nucleotide bindingi566 – 5694GTPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2219-MONOMER.
BMEL359391:GJOQ-2219-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:BAB1_2165
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 959959Translation initiation factor IF-2PRO_0000228176Add
BLAST

Proteomic databases

PRIDEiQ2YQR7.

Structurei

3D structure databases

ProteinModelPortaliQ2YQR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini457 – 626170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni466 – 4738G1By similarity
Regioni491 – 4955G2By similarity
Regioni512 – 5154G3By similarity
Regioni566 – 5694G4By similarity
Regioni602 – 6043G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiVENTPNK.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YQR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKTNDDKT LSVNPKKTLT LKRPGVEQST VRQNFSHGRT KAVVVETKKR
60 70 80 90 100
KFSRPDEKPE VEAAAAPKPA APAAAPQQAP ASAPVSASAA QASAPQPAPV
110 120 130 140 150
KAPATKAPAA PSAPVTKPHV AQQRPVHQRP GGQQAQRPRP ADRSGMVLNT
160 170 180 190 200
LSRSEMDARR RALEEAQIRE VEERARAVEE AKRRAEEDAR RAKEREESAR
210 220 230 240 250
RQAEEEARLK AEAEARRKAE EEAAKRMPQP EARSERRDDA RPAPYGARPQ
260 270 280 290 300
QAGRPQGGRP QPAGRPQQGS PRPAPIIADA APIAGKPLPQ SQLRKPGQSD
310 320 330 340 350
DDDDRRSGAA RRGVAAKPEV RAPKVVKGED DRRRGKLTLT SNLEEEGRSR
360 370 380 390 400
SLSAMRRRQE KFKRSQMQET REKISREVTI PETITLQELA QRMAERSVDI
410 420 430 440 450
IKYLMKQGQM MKPGDVIDAD TAQLIAEEFG HTVKRVAESD VEEGIFDVAD
460 470 480 490 500
NESAMVSRPP VVTIMGHVDH GKTSLLDAIR HANVVSGEAG GITQHIGAYQ
510 520 530 540 550
VVQNGQKITF IDTPGHAAFT AMRARGAQAT DIAILVVAAD DSVMPQTIES
560 570 580 590 600
INHAKAAGVP IIVAINKIDK PAADPQKVRT ALLQHEVFVE SMGGEVLDVE
610 620 630 640 650
VSAKNKINLD KLLDAVLLQA EMLDLKADPD RTAEGVVIEA QLDRGRGSVA
660 670 680 690 700
TVLIQKGTLH PGDILVAGSE WGRVRALVND RGEHVKEAGP AMPVEILGLQ
710 720 730 740 750
GTPQAGDRFA VVANEAKARE IAEYRQRLAR DKAVARQSGA RGSLEQMMNQ
760 770 780 790 800
LQVSGTKEFP LVIKGDVQGS IEAITNALDK LGTDEVRARI VHSGAGGITE
810 820 830 840 850
SDVSLAEASN AAIIGFNVRA NKQARDSAEQ QGIEIRYYNI IYDLIDDVKA
860 870 880 890 900
AMSGLLSPER RETFLGNAEI LEVFNITKVG KVAGCRVTEG KVERGAGVRL
910 920 930 940 950
IRDNVVIHEG KLKTLKRFKD EVAEVPSGQE CGMAFENYDD IRAGDVIEAF

RVEHVSRTL
Length:959
Mass (Da):104,141
Last modified:February 7, 2006 - v1
Checksum:i68B272FD63479FEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ12121.1.
RefSeqiWP_002965227.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ12121; CAJ12121; BAB1_2165.
GeneIDi3788765.
KEGGibmf:BAB1_2165.
PATRICi17847437. VBIBruMel86222_2254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ12121.1.
RefSeqiWP_002965227.1. NZ_KN046823.1.

3D structure databases

ProteinModelPortaliQ2YQR7.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2YQR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ12121; CAJ12121; BAB1_2165.
GeneIDi3788765.
KEGGibmf:BAB1_2165.
PATRICi17847437. VBIBruMel86222_2254.

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076907.
KOiK02519.
OMAiVENTPNK.
OrthoDBiEOG67HJSV.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2219-MONOMER.
BMEL359391:GJOQ-2219-MONOMER.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiIF2_BRUA2
AccessioniPrimary (citable) accession number: Q2YQR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: February 7, 2006
Last modified: July 22, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.