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Q2YQR7 (IF2_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:BAB1_2165
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length959 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 959959Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_0000228176

Regions

Nucleotide binding466 – 4738GTP By similarity
Nucleotide binding512 – 5165GTP By similarity
Nucleotide binding566 – 5694GTP By similarity
Region460 – 608149G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
Q2YQR7 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 68B272FD63479FEE

FASTA959104,141
        10         20         30         40         50         60 
MSDKTNDDKT LSVNPKKTLT LKRPGVEQST VRQNFSHGRT KAVVVETKKR KFSRPDEKPE 

        70         80         90        100        110        120 
VEAAAAPKPA APAAAPQQAP ASAPVSASAA QASAPQPAPV KAPATKAPAA PSAPVTKPHV 

       130        140        150        160        170        180 
AQQRPVHQRP GGQQAQRPRP ADRSGMVLNT LSRSEMDARR RALEEAQIRE VEERARAVEE 

       190        200        210        220        230        240 
AKRRAEEDAR RAKEREESAR RQAEEEARLK AEAEARRKAE EEAAKRMPQP EARSERRDDA 

       250        260        270        280        290        300 
RPAPYGARPQ QAGRPQGGRP QPAGRPQQGS PRPAPIIADA APIAGKPLPQ SQLRKPGQSD 

       310        320        330        340        350        360 
DDDDRRSGAA RRGVAAKPEV RAPKVVKGED DRRRGKLTLT SNLEEEGRSR SLSAMRRRQE 

       370        380        390        400        410        420 
KFKRSQMQET REKISREVTI PETITLQELA QRMAERSVDI IKYLMKQGQM MKPGDVIDAD 

       430        440        450        460        470        480 
TAQLIAEEFG HTVKRVAESD VEEGIFDVAD NESAMVSRPP VVTIMGHVDH GKTSLLDAIR 

       490        500        510        520        530        540 
HANVVSGEAG GITQHIGAYQ VVQNGQKITF IDTPGHAAFT AMRARGAQAT DIAILVVAAD 

       550        560        570        580        590        600 
DSVMPQTIES INHAKAAGVP IIVAINKIDK PAADPQKVRT ALLQHEVFVE SMGGEVLDVE 

       610        620        630        640        650        660 
VSAKNKINLD KLLDAVLLQA EMLDLKADPD RTAEGVVIEA QLDRGRGSVA TVLIQKGTLH 

       670        680        690        700        710        720 
PGDILVAGSE WGRVRALVND RGEHVKEAGP AMPVEILGLQ GTPQAGDRFA VVANEAKARE 

       730        740        750        760        770        780 
IAEYRQRLAR DKAVARQSGA RGSLEQMMNQ LQVSGTKEFP LVIKGDVQGS IEAITNALDK 

       790        800        810        820        830        840 
LGTDEVRARI VHSGAGGITE SDVSLAEASN AAIIGFNVRA NKQARDSAEQ QGIEIRYYNI 

       850        860        870        880        890        900 
IYDLIDDVKA AMSGLLSPER RETFLGNAEI LEVFNITKVG KVAGCRVTEG KVERGAGVRL 

       910        920        930        940        950 
IRDNVVIHEG KLKTLKRFKD EVAEVPSGQE CGMAFENYDD IRAGDVIEAF RVEHVSRTL 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ12121.1.
RefSeqYP_415485.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YQR7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_2165.

Proteomic databases

PRIDEQ2YQR7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ12121; CAJ12121; BAB1_2165.
GeneID3788765.
KEGGbmf:BAB1_2165.
PATRIC17847437. VBIBruMel86222_2254.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076907.
KOK02519.
OMADATGKTR.
OrthoDBEOG67HJSV.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2219-MONOMER.
BMEL359391:GJOQ-2219-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR013575. IF2_assoc_dom_bac.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF08364. IF2_assoc. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_BRUA2
AccessionPrimary (citable) accession number: Q2YQR7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names