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Protein
Submitted name:

Beta-ketoacyl synthase

Gene

fabB

Organism
Brucella abortus (strain 2308)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2227-MONOMER.
BMEL359391:GJOQ-2227-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-ketoacyl synthaseImported (EC:2.3.1.41Imported)
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:fabBImported
Ordered Locus Names:BAB1_2173Imported
ORF Names:DK47_1498Imported
OrganismiBrucella abortus (strain 2308)Imported
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

PTM / Processingi

Proteomic databases

PRIDEiQ2YQQ9.

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_2173.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LRFX-ray1.60A1-407[»]
3MQDX-ray1.25A1-407[»]
3U0EX-ray1.60A1-407[»]
3U0FX-ray1.25A1-407[»]
4JV3X-ray1.70A1-407[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2YQQ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060165.
KOiK00647.
OMAiNHVAMDQ.
OrthoDBiEOG6DG2SR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YQQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRVVVTGMG IVSSIGSNTE EVTASLREAK SGISRAEEYA ELGFRCQVHG
60 70 80 90 100
APDIDIESLV DRRAMRFHGR GTAWNHIAMD QAIADAGLTE EEVSNERTGI
110 120 130 140 150
IMGSGGPSTR TIVDSADITR EKGPKRVGPF AVPKAMSSTA SATLATFFKI
160 170 180 190 200
KGINYSISSA CATSNHCIGN AYEMIQYGKQ DRMFAGGCED LDWTLSVLFD
210 220 230 240 250
AMGAMSSKYN DTPSTASRAY DKNRDGFVIA GGAGVLVLED LETALARGAK
260 270 280 290 300
IYGEIVGYGA TSDGYDMVAP SGEGAIRCMK MALSTVTSKI DYINPHATST
310 320 330 340 350
PAGDAPEIEA IRQIFGAGDV CPPIAATKSL TGHSLGATGV QEAIYSLLMM
360 370 380 390 400
QNNFICESAH IEELDPAFAD MPIVRKRIDN VQLNTVLSNS FGFGGTNATL

VFQRYQG
Length:407
Mass (Da):43,311
Last modified:February 7, 2006 - v1
Checksum:i26DB912A67F0AD07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ12129.1.
JMRZ01000006 Genomic DNA. Translation: KFJ51778.1.
RefSeqiYP_415493.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ12129; CAJ12129; BAB1_2173.
GeneIDi3788695.
KEGGibmf:BAB1_2173.
PATRICi17847453. VBIBruMel86222_2262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ12129.1.
JMRZ01000006 Genomic DNA. Translation: KFJ51778.1.
RefSeqiYP_415493.1. NC_007618.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LRFX-ray1.60A1-407[»]
3MQDX-ray1.25A1-407[»]
3U0EX-ray1.60A1-407[»]
3U0FX-ray1.25A1-407[»]
4JV3X-ray1.70A1-407[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359391.BAB1_2173.

Proteomic databases

PRIDEiQ2YQQ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ12129; CAJ12129; BAB1_2173.
GeneIDi3788695.
KEGGibmf:BAB1_2173.
PATRICi17847453. VBIBruMel86222_2262.

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060165.
KOiK00647.
OMAiNHVAMDQ.
OrthoDBiEOG6DG2SR.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2227-MONOMER.
BMEL359391:GJOQ-2227-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ2YQQ9.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2308Imported.
  3. "CRYSTAL structure of beta-ketoacyl synthase from brucella melitensis."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Abendroth J., Edwards T., Staker B.
    Submitted (FEB-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
  4. "Crystal structure of beta-ketoacyl synthase from brucella melitensis with FOL 0758, (1-methyl-1h-indazol-3-yl) methanol."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Abendroth J., Gardberg A., Sankaran B., Staker B.
    Submitted (APR-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS).
  5. "Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with fragment 9320."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Abendroth J., Sankaran B., Davies D.R., Leonard J., Staker B.
    Submitted (SEP-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
  6. "The structure of Beta-ketoacyl synthase from Brucella melitensis bound to the fragment 7-hydroxycoumarin."
    Clifton M.C., Abendroth J., Seattle Structural Genomics Center for Infectious Disease
    Submitted (SEP-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS).
  7. "Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with platencin."
    Abendroth J., Fairman J.W., Lorimer D., Edwards T.
    Submitted (MAR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2308Imported.

Entry informationi

Entry nameiQ2YQQ9_BRUA2
AccessioniPrimary (citable) accession number: Q2YQQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 7, 2006
Last sequence update: February 7, 2006
Last modified: March 4, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.