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Q2YQQ9

- Q2YQQ9_BRUA2

UniProt

Q2YQQ9 - Q2YQQ9_BRUA2

Protein
Submitted name:

Beta-ketoacyl synthase

Gene

fabB

Organism
Brucella abortus (strain 2308)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi294 – 2941SodiumImported
    Metal bindingi295 – 2951Sodium; via carbonyl oxygenImported
    Metal bindingi342 – 3421SodiumImported
    Metal bindingi388 – 3881SodiumImported
    Metal bindingi389 – 3891Sodium; via carbonyl oxygenImported

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    AcyltransferaseImported, Transferase

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2227-MONOMER.
    BMEL359391:GJOQ-2227-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Beta-ketoacyl synthaseImported (EC:2.3.1.41Imported)
    Gene namesi
    Name:fabBImported
    Ordered Locus Names:BAB1_2173Imported
    OrganismiBrucella abortus (strain 2308)Imported
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    PTM / Processingi

    Proteomic databases

    PRIDEiQ2YQQ9.

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB1_2173.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LRFX-ray1.60A1-407[»]
    3MQDX-ray1.25A1-407[»]
    3U0EX-ray1.60A1-407[»]
    3U0FX-ray1.25A1-407[»]
    4JV3X-ray1.70A1-407[»]
    ProteinModelPortaliQ2YQQ9.
    SMRiQ2YQQ9. Positions 1-406.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ2YQQ9.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0304.
    HOGENOMiHOG000060165.
    KOiK00647.
    OMAiFNPEYAE.
    OrthoDBiEOG6DG2SR.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YQQ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRVVVTGMG IVSSIGSNTE EVTASLREAK SGISRAEEYA ELGFRCQVHG    50
    APDIDIESLV DRRAMRFHGR GTAWNHIAMD QAIADAGLTE EEVSNERTGI 100
    IMGSGGPSTR TIVDSADITR EKGPKRVGPF AVPKAMSSTA SATLATFFKI 150
    KGINYSISSA CATSNHCIGN AYEMIQYGKQ DRMFAGGCED LDWTLSVLFD 200
    AMGAMSSKYN DTPSTASRAY DKNRDGFVIA GGAGVLVLED LETALARGAK 250
    IYGEIVGYGA TSDGYDMVAP SGEGAIRCMK MALSTVTSKI DYINPHATST 300
    PAGDAPEIEA IRQIFGAGDV CPPIAATKSL TGHSLGATGV QEAIYSLLMM 350
    QNNFICESAH IEELDPAFAD MPIVRKRIDN VQLNTVLSNS FGFGGTNATL 400
    VFQRYQG 407
    Length:407
    Mass (Da):43,311
    Last modified:February 7, 2006 - v1
    Checksum:i26DB912A67F0AD07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ12129.1.
    RefSeqiYP_415493.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ12129; CAJ12129; BAB1_2173.
    GeneIDi3788695.
    KEGGibmf:BAB1_2173.
    PATRICi17847453. VBIBruMel86222_2262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ12129.1 .
    RefSeqi YP_415493.1. NC_007618.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LRF X-ray 1.60 A 1-407 [» ]
    3MQD X-ray 1.25 A 1-407 [» ]
    3U0E X-ray 1.60 A 1-407 [» ]
    3U0F X-ray 1.25 A 1-407 [» ]
    4JV3 X-ray 1.70 A 1-407 [» ]
    ProteinModelPortali Q2YQQ9.
    SMRi Q2YQQ9. Positions 1-406.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_2173.

    Proteomic databases

    PRIDEi Q2YQQ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ12129 ; CAJ12129 ; BAB1_2173 .
    GeneIDi 3788695.
    KEGGi bmf:BAB1_2173.
    PATRICi 17847453. VBIBruMel86222_2262.

    Phylogenomic databases

    eggNOGi COG0304.
    HOGENOMi HOG000060165.
    KOi K00647.
    OMAi FNPEYAE.
    OrthoDBi EOG6DG2SR.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-2227-MONOMER.
    BMEL359391:GJOQ-2227-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q2YQQ9.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308Imported.
    2. "CRYSTAL structure of beta-ketoacyl synthase from brucella melitensis."
      Seattle Structural Genomics Center for Infectious Disease (SSGCID)
      Abendroth J., Edwards T., Staker B.
      Submitted (FEB-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
    3. "Crystal structure of beta-ketoacyl synthase from brucella melitensis with FOL 0758, (1-methyl-1h-indazol-3-yl) methanol."
      Seattle Structural Genomics Center for Infectious Disease (SSGCID)
      Abendroth J., Gardberg A., Sankaran B., Staker B.
      Submitted (APR-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS).
    4. "Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with fragment 9320."
      Seattle Structural Genomics Center for Infectious Disease (SSGCID)
      Abendroth J., Sankaran B., Davies D.R., Leonard J., Staker B.
      Submitted (SEP-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
    5. "The structure of Beta-ketoacyl synthase from Brucella melitensis bound to the fragment 7-hydroxycoumarin."
      Clifton M.C., Abendroth J., Seattle Structural Genomics Center for Infectious Disease
      Submitted (SEP-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS).
    6. "Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with platencin."
      Abendroth J., Fairman J.W., Lorimer D., Edwards T.
      Submitted (MAR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).

    Entry informationi

    Entry nameiQ2YQQ9_BRUA2
    AccessioniPrimary (citable) accession number: Q2YQQ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 7, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3