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Q2YQQ9

- Q2YQQ9_BRUA2

UniProt

Q2YQQ9 - Q2YQQ9_BRUA2

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Protein
Submitted name:

Beta-ketoacyl synthase

Gene

fabB

Organism
Brucella abortus (strain 2308)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi294 – 2941SodiumImported
Metal bindingi295 – 2951Sodium; via carbonyl oxygenImported
Metal bindingi342 – 3421SodiumImported
Metal bindingi388 – 3881SodiumImported
Metal bindingi389 – 3891Sodium; via carbonyl oxygenImported

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2227-MONOMER.
BMEL359391:GJOQ-2227-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-ketoacyl synthaseImported (EC:2.3.1.41Imported)
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:fabBImported
Ordered Locus Names:BAB1_2173Imported
ORF Names:DK47_1498Imported
OrganismiBrucella abortus (strain 2308)Imported
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

PTM / Processingi

Proteomic databases

PRIDEiQ2YQQ9.

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_2173.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LRFX-ray1.60A1-407[»]
3MQDX-ray1.25A1-407[»]
3U0EX-ray1.60A1-407[»]
3U0FX-ray1.25A1-407[»]
4JV3X-ray1.70A1-407[»]
ProteinModelPortaliQ2YQQ9.
SMRiQ2YQQ9. Positions 1-406.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ2YQQ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060165.
KOiK00647.
OMAiFNPEYAE.
OrthoDBiEOG6DG2SR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YQQ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRVVVTGMG IVSSIGSNTE EVTASLREAK SGISRAEEYA ELGFRCQVHG
60 70 80 90 100
APDIDIESLV DRRAMRFHGR GTAWNHIAMD QAIADAGLTE EEVSNERTGI
110 120 130 140 150
IMGSGGPSTR TIVDSADITR EKGPKRVGPF AVPKAMSSTA SATLATFFKI
160 170 180 190 200
KGINYSISSA CATSNHCIGN AYEMIQYGKQ DRMFAGGCED LDWTLSVLFD
210 220 230 240 250
AMGAMSSKYN DTPSTASRAY DKNRDGFVIA GGAGVLVLED LETALARGAK
260 270 280 290 300
IYGEIVGYGA TSDGYDMVAP SGEGAIRCMK MALSTVTSKI DYINPHATST
310 320 330 340 350
PAGDAPEIEA IRQIFGAGDV CPPIAATKSL TGHSLGATGV QEAIYSLLMM
360 370 380 390 400
QNNFICESAH IEELDPAFAD MPIVRKRIDN VQLNTVLSNS FGFGGTNATL

VFQRYQG
Length:407
Mass (Da):43,311
Last modified:February 7, 2006 - v1
Checksum:i26DB912A67F0AD07
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ12129.1.
JMRZ01000006 Genomic DNA. Translation: KFJ51778.1.
RefSeqiYP_415493.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ12129; CAJ12129; BAB1_2173.
GeneIDi3788695.
KEGGibmf:BAB1_2173.
PATRICi17847453. VBIBruMel86222_2262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ12129.1 .
JMRZ01000006 Genomic DNA. Translation: KFJ51778.1 .
RefSeqi YP_415493.1. NC_007618.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3LRF X-ray 1.60 A 1-407 [» ]
3MQD X-ray 1.25 A 1-407 [» ]
3U0E X-ray 1.60 A 1-407 [» ]
3U0F X-ray 1.25 A 1-407 [» ]
4JV3 X-ray 1.70 A 1-407 [» ]
ProteinModelPortali Q2YQQ9.
SMRi Q2YQQ9. Positions 1-406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_2173.

Proteomic databases

PRIDEi Q2YQQ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ12129 ; CAJ12129 ; BAB1_2173 .
GeneIDi 3788695.
KEGGi bmf:BAB1_2173.
PATRICi 17847453. VBIBruMel86222_2262.

Phylogenomic databases

eggNOGi COG0304.
HOGENOMi HOG000060165.
KOi K00647.
OMAi FNPEYAE.
OrthoDBi EOG6DG2SR.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-2227-MONOMER.
BMEL359391:GJOQ-2227-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q2YQQ9.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2308Imported.
  3. "CRYSTAL structure of beta-ketoacyl synthase from brucella melitensis."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Abendroth J., Edwards T., Staker B.
    Submitted (FEB-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
  4. "Crystal structure of beta-ketoacyl synthase from brucella melitensis with FOL 0758, (1-methyl-1h-indazol-3-yl) methanol."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Abendroth J., Gardberg A., Sankaran B., Staker B.
    Submitted (APR-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS).
  5. "Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with fragment 9320."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Abendroth J., Sankaran B., Davies D.R., Leonard J., Staker B.
    Submitted (SEP-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
  6. "The structure of Beta-ketoacyl synthase from Brucella melitensis bound to the fragment 7-hydroxycoumarin."
    Clifton M.C., Abendroth J., Seattle Structural Genomics Center for Infectious Disease
    Submitted (SEP-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS).
  7. "Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with platencin."
    Abendroth J., Fairman J.W., Lorimer D., Edwards T.
    Submitted (MAR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2308Imported.

Entry informationi

Entry nameiQ2YQQ9_BRUA2
AccessioniPrimary (citable) accession number: Q2YQQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 7, 2006
Last sequence update: February 7, 2006
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3