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Q2YQQ9

- Q2YQQ9_BRUA2

UniProt

Q2YQQ9 - Q2YQQ9_BRUA2

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Protein
Submitted name:

Beta-ketoacyl synthase

Gene
fabB, BAB1_2173
Organism
Brucella abortus (strain 2308)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi294 – 2941SodiumImported
Metal bindingi295 – 2951Sodium; via carbonyl oxygenImported
Metal bindingi342 – 3421SodiumImported
Metal bindingi388 – 3881SodiumImported
Metal bindingi389 – 3891Sodium; via carbonyl oxygenImported

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Keywords - Ligandi

Metal-bindingImported, SodiumImported

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2227-MONOMER.
BMEL359391:GJOQ-2227-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-ketoacyl synthaseImported (EC:2.3.1.41Imported)
Gene namesi
Name:fabBImported
Ordered Locus Names:BAB1_2173Imported
OrganismiBrucella abortus (strain 2308)Imported
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

PTM / Processingi

Proteomic databases

PRIDEiQ2YQQ9.

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_2173.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LRFX-ray1.60A1-407[»]
3MQDX-ray1.25A1-407[»]
3U0EX-ray1.60A1-407[»]
3U0FX-ray1.25A1-407[»]
4JV3X-ray1.70A1-407[»]
ProteinModelPortaliQ2YQQ9.
SMRiQ2YQQ9. Positions 1-406.

Miscellaneous databases

EvolutionaryTraceiQ2YQQ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060165.
KOiK00647.
OMAiFNPEYAE.
OrthoDBiEOG6DG2SR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YQQ9-1 [UniParc]FASTAAdd to Basket

« Hide

MRRVVVTGMG IVSSIGSNTE EVTASLREAK SGISRAEEYA ELGFRCQVHG    50
APDIDIESLV DRRAMRFHGR GTAWNHIAMD QAIADAGLTE EEVSNERTGI 100
IMGSGGPSTR TIVDSADITR EKGPKRVGPF AVPKAMSSTA SATLATFFKI 150
KGINYSISSA CATSNHCIGN AYEMIQYGKQ DRMFAGGCED LDWTLSVLFD 200
AMGAMSSKYN DTPSTASRAY DKNRDGFVIA GGAGVLVLED LETALARGAK 250
IYGEIVGYGA TSDGYDMVAP SGEGAIRCMK MALSTVTSKI DYINPHATST 300
PAGDAPEIEA IRQIFGAGDV CPPIAATKSL TGHSLGATGV QEAIYSLLMM 350
QNNFICESAH IEELDPAFAD MPIVRKRIDN VQLNTVLSNS FGFGGTNATL 400
VFQRYQG 407
Length:407
Mass (Da):43,311
Last modified:February 7, 2006 - v1
Checksum:i26DB912A67F0AD07
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ12129.1.
RefSeqiYP_415493.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ12129; CAJ12129; BAB1_2173.
GeneIDi3788695.
KEGGibmf:BAB1_2173.
PATRICi17847453. VBIBruMel86222_2262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ12129.1 .
RefSeqi YP_415493.1. NC_007618.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3LRF X-ray 1.60 A 1-407 [» ]
3MQD X-ray 1.25 A 1-407 [» ]
3U0E X-ray 1.60 A 1-407 [» ]
3U0F X-ray 1.25 A 1-407 [» ]
4JV3 X-ray 1.70 A 1-407 [» ]
ProteinModelPortali Q2YQQ9.
SMRi Q2YQQ9. Positions 1-406.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_2173.

Proteomic databases

PRIDEi Q2YQQ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ12129 ; CAJ12129 ; BAB1_2173 .
GeneIDi 3788695.
KEGGi bmf:BAB1_2173.
PATRICi 17847453. VBIBruMel86222_2262.

Phylogenomic databases

eggNOGi COG0304.
HOGENOMi HOG000060165.
KOi K00647.
OMAi FNPEYAE.
OrthoDBi EOG6DG2SR.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-2227-MONOMER.
BMEL359391:GJOQ-2227-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q2YQQ9.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308Imported.
  2. "CRYSTAL structure of beta-ketoacyl synthase from brucella melitensis."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Abendroth J., Edwards T., Staker B.
    Submitted (FEB-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH SODIUM.
  3. "Crystal structure of beta-ketoacyl synthase from brucella melitensis with FOL 0758, (1-methyl-1h-indazol-3-yl) methanol."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Abendroth J., Gardberg A., Sankaran B., Staker B.
    Submitted (APR-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) IN COMPLEX WITH SODIUM.
  4. "Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with fragment 9320."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Abendroth J., Sankaran B., Davies D.R., Leonard J., Staker B.
    Submitted (SEP-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH SODIUM.
  5. "The structure of Beta-ketoacyl synthase from Brucella melitensis bound to the fragment 7-hydroxycoumarin."
    Clifton M.C., Abendroth J., Seattle Structural Genomics Center for Infectious Disease
    Submitted (SEP-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) IN COMPLEX WITH SODIUM.
  6. "Crystal structure of beta-ketoacyl synthase from Brucella melitensis in complex with platencin."
    Abendroth J., Fairman J.W., Lorimer D., Edwards T.
    Submitted (MAR-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).

Entry informationi

Entry nameiQ2YQQ9_BRUA2
AccessioniPrimary (citable) accession number: Q2YQQ9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 7, 2006
Last sequence update: February 7, 2006
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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