ID   KUP_BRUA2               Reviewed;         651 AA.
AC   Q2YQM9;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   RecName: Full=Probable potassium transport system protein Kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   OrderedLocusNames=BAB1_1402;
OS   Brucella abortus (strain 2308).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: Transport of potassium into the cell. Likely operates as a
CC       K(+):H(+) symporter. {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(in) + K(+)(in) = H(+)(out) + K(+)(out);
CC         Xref=Rhea:RHEA:28490, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01522};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28492;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01522};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM040264; CAJ11358.1; -; Genomic_DNA.
DR   RefSeq; WP_002964493.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q2YQM9; -.
DR   STRING; 359391.BAB1_1402; -.
DR   GeneID; 3787968; -.
DR   KEGG; bmf:BAB1_1402; -.
DR   PATRIC; fig|359391.11.peg.852; -.
DR   HOGENOM; CLU_008142_4_2_5; -.
DR   PhylomeDB; Q2YQM9; -.
DR   Proteomes; UP000002719; Chromosome I.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; Kup.
DR   PANTHER; PTHR30540:SF79; LOW AFFINITY POTASSIUM TRANSPORT SYSTEM PROTEIN KUP; 1.
DR   PANTHER; PTHR30540; OSMOTIC STRESS POTASSIUM TRANSPORTER; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Reference proteome; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..651
FT                   /note="Probable potassium transport system protein Kup"
FT                   /id="PRO_0000279768"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   651 AA;  70413 MW;  A019853534C7D0D2 CRC64;
     MSGELNGNDT SAQAAVSAGS VLEGAAFADE GEQHNESMKT LVLGALGVVY GDIGTSPIYA
     FREALHAAAT NGILARSDIL GVVSLIFWAL TLVVTVKYVL FVLRADNNGE GGILSLMALV
     RGALKGRPDL ILGVGICGAA LFFGDAVITP AISVLSAMEG LEIVAPNLTP FVVPAAVVIL
     VTLFSVQKLG TGRVAIVFGP IMALWFVALG ASGLWHIFDD PTVMAALNPY YAVRFLTVSP
     AVAFVTVGAV FLAMTGAEAL YADLGHFGRK PIVRAWLWIV FPCLLLNYFG QAAFILSHGE
     AAALPFFQMI PSFALWPMVL LATAATVIAS QAVITGAYSV ARQAVQLNIL PRLEIQHTSE
     KLHGQIYIPR VNLLLGLAVV ILVLGFEKSS NLAAAYGIAV TGNMLVTTVL LYIAMTRIWN
     WRVSRALPII LGFLVIDMLF FSANIIKVHE GGWASIGIAT VLVLIMWTWV RGTRHLFQKT
     RKAEVPLDLI VEQMAKRPPT IVPGTAVFLT GDPKSAPTAL MHSLKHYKVL HENNVILTVV
     TASKPWVASA DRARVSQYNE RFMLVTLTFG YMQQPNIPRA LGLCRRLGWK FDIMTTSFFL
     SRRSLKASVH SGMPLWQDKL FILLARTASD ATEYFQIPTG RVVEIGTQVN I
//