Q2YQM9 (KUP_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable potassium transport system protein kup

Gene names

Name:	kup
Ordered Locus Names:	BAB1_1402

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	651 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transport of potassium into the cell By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01522.
Sequence similarities	Belongs to the HAK/KUP transporter (TC 2.A.72) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium ion transmembrane transporter activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 651	651	Probable potassium transport system protein kup HAMAP-Rule MF_01522		PRO_0000279768
Regions
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Transmembrane	130 – 150	21	Helical; Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Transmembrane	194 – 214	21	Helical; Potential
	Transmembrane	235 – 255	21	Helical; Potential
	Transmembrane	276 – 296	21	Helical; Potential
	Transmembrane	309 – 329	21	Helical; Potential
	Transmembrane	366 – 386	21	Helical; Potential
	Transmembrane	395 – 415	21	Helical; Potential
	Transmembrane	426 – 446	21	Helical; Potential
	Transmembrane	450 – 470	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2YQM9 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: A019853534C7D0D2	FASTA	651	70,413
	10 20 30 40 50 60 MSGELNGNDT SAQAAVSAGS VLEGAAFADE GEQHNESMKT LVLGALGVVY GDIGTSPIYA 70 80 90 100 110 120 FREALHAAAT NGILARSDIL GVVSLIFWAL TLVVTVKYVL FVLRADNNGE GGILSLMALV 130 140 150 160 170 180 RGALKGRPDL ILGVGICGAA LFFGDAVITP AISVLSAMEG LEIVAPNLTP FVVPAAVVIL 190 200 210 220 230 240 VTLFSVQKLG TGRVAIVFGP IMALWFVALG ASGLWHIFDD PTVMAALNPY YAVRFLTVSP 250 260 270 280 290 300 AVAFVTVGAV FLAMTGAEAL YADLGHFGRK PIVRAWLWIV FPCLLLNYFG QAAFILSHGE 310 320 330 340 350 360 AAALPFFQMI PSFALWPMVL LATAATVIAS QAVITGAYSV ARQAVQLNIL PRLEIQHTSE 370 380 390 400 410 420 KLHGQIYIPR VNLLLGLAVV ILVLGFEKSS NLAAAYGIAV TGNMLVTTVL LYIAMTRIWN 430 440 450 460 470 480 WRVSRALPII LGFLVIDMLF FSANIIKVHE GGWASIGIAT VLVLIMWTWV RGTRHLFQKT 490 500 510 520 530 540 RKAEVPLDLI VEQMAKRPPT IVPGTAVFLT GDPKSAPTAL MHSLKHYKVL HENNVILTVV 550 560 570 580 590 600 TASKPWVASA DRARVSQYNE RFMLVTLTFG YMQQPNIPRA LGLCRRLGWK FDIMTTSFFL 610 620 630 640 650 SRRSLKASVH SGMPLWQDKL FILLARTASD ATEYFQIPTG RVVEIGTQVN I

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040264 Genomic DNA. Translation: CAJ11358.1.
RefSeq	YP_414774.1. NC_007618.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB1_1402.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ11358; CAJ11358; BAB1_1402.
GeneID	3787968.
KEGG	bmf:BAB1_1402.
PATRIC	17845788. VBIBruMel86222_1457.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3158.
HOGENOM	HOG000218033.
KO	K03549.
OMA	PESARID.
ProtClustDB	CLSK863270.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-1432-MONOMER.
Family and domain databases
HAMAP	MF_01522. Kup.
InterPro	IPR003855. K+_transporter. IPR023051. K+_uptake_low_affin. [Graphical view]
Pfam	PF02705. K_trans. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KUP_BRUA2

Accession

Primary (citable) accession number: Q2YQM9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program