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Q2YQM7

- PDXJ_BRUA2

UniProt

Q2YQM7 - PDXJ_BRUA2

Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

    Catalytic activityi

    1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei8 – 813-amino-2-oxopropyl phosphateUniRule annotation
    Binding sitei19 – 1913-amino-2-oxopropyl phosphateUniRule annotation
    Active sitei44 – 441Proton acceptorUniRule annotation
    Binding sitei46 – 4611-deoxy-D-xylulose 5-phosphateUniRule annotation
    Binding sitei51 – 5111-deoxy-D-xylulose 5-phosphateUniRule annotation
    Active sitei76 – 761Proton acceptorUniRule annotation
    Binding sitei106 – 10611-deoxy-D-xylulose 5-phosphateUniRule annotation
    Sitei157 – 1571Transition state stabilizerUniRule annotation
    Active sitei198 – 1981Proton donorUniRule annotation
    Binding sitei199 – 19913-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-1434-MONOMER.
    BMEL359391:GJOQ-1434-MONOMER.
    UniPathwayiUPA00244; UER00313.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
    Short name:
    PNP synthaseUniRule annotation
    Gene namesi
    Name:pdxJUniRule annotation
    Ordered Locus Names:BAB1_1404
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Pyridoxine 5'-phosphate synthasePRO_0000231791Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer; tetramer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_1404.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YQM7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni221 – 22223-amino-2-oxopropyl phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0854.
    HOGENOMiHOG000258095.
    KOiK03474.
    OMAiVPETRQE.
    OrthoDBiEOG6M9F0H.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00279. PdxJ.
    InterProiIPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view]
    PfamiPF03740. PdxJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF63892. SSF63892. 1 hit.
    TIGRFAMsiTIGR00559. pdxJ. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YQM7-1 [UniParc]FASTAAdd to Basket

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    MPAKLSVNLN AIAMLRNRRD LPWPSVTGLG RAALAAGAAG LTVHPRPDQR    50
    HIRFSDLGDI RALIDDEYPQ AEFNIEGFPS EAFLDLVEKH EPEQVTLVPD 100
    DPMQATSDHG WDFMSKADFL APIVARLKGR GMRVSLFADP DSLGYERAKA 150
    IGADRVELYT GPYGATHDDP AAAARELDRL EKAARAATAL GLAVNAGHDL 200
    TVDNLPALVK RIPQLAEVSI GHGLTADALM YGIPVTVSRY ITALAG 246
    Length:246
    Mass (Da):26,466
    Last modified:February 7, 2006 - v1
    Checksum:i7AEF11306AE7B475
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11360.1.
    RefSeqiYP_414776.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ11360; CAJ11360; BAB1_1404.
    GeneIDi3787970.
    KEGGibmf:BAB1_1404.
    PATRICi17845792. VBIBruMel86222_1459.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11360.1 .
    RefSeqi YP_414776.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YQM7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_1404.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ11360 ; CAJ11360 ; BAB1_1404 .
    GeneIDi 3787970.
    KEGGi bmf:BAB1_1404.
    PATRICi 17845792. VBIBruMel86222_1459.

    Phylogenomic databases

    eggNOGi COG0854.
    HOGENOMi HOG000258095.
    KOi K03474.
    OMAi VPETRQE.
    OrthoDBi EOG6M9F0H.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00313 .
    BioCyci BABO359391:GKDV-1434-MONOMER.
    BMEL359391:GJOQ-1434-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00279. PdxJ.
    InterProi IPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view ]
    Pfami PF03740. PdxJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63892. SSF63892. 1 hit.
    TIGRFAMsi TIGR00559. pdxJ. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiPDXJ_BRUA2
    AccessioniPrimary (citable) accession number: Q2YQM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3