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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathway:iadenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1345-MONOMER.
BMEL359391:GJOQ-1345-MONOMER.
UniPathwayiUPA00148; UER00227.

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:BAB1_1318
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Cobalt-precorrin-5B C(1)-methyltransferasePRO_0000257749Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2YQL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1903.
HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.
OrthoDBiEOG6WX4M7.

Family and domain databases

HAMAPiMF_00787. CbiD.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YQL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDETTPANK NPEKAELRCG WTTGACATAA TKAALTALIT GEFPDPVGII
60 70 80 90 100
LPKGEVPYFQ LAYEGLGEGY AMAGIVKDAG DDPDVTHGAT IISTVYPAPP
110 120 130 140 150
GTGIIFRAGE GVGTVTREGL AIPPGEAAIN PVPRRMMTEI CEAICAEYGL
160 170 180 190 200
PADLVITISV PGGEEIAQKT WNPRLGIIGG ISILGTTGVV HPFSCSAWIH
210 220 230 240 250
SIHRGIDVAR AAGQKHVLGA TGSTSEDAAQ ALYNLPDFAI LDMGDFAGGV
260 270 280 290 300
LKYLREHPID RLTIAGGFAK LTKLAQGALD LHSSRSQVDK GFLWQIAERA
310 320 330 340 350
GAPAGMKERI LLANTAMEVL ELTQSIGIDI AGPIALEARQ TALKTLRGAP
360
VEVEIIVTDR KGNILARV
Length:368
Mass (Da):38,530
Last modified:February 7, 2006 - v1
Checksum:i5F3040A081BDFFDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11274.1.
RefSeqiWP_002964416.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ11274; CAJ11274; BAB1_1318.
GeneIDi3788641.
KEGGibmf:BAB1_1318.
PATRICi17845613. VBIBruMel86222_1371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11274.1.
RefSeqiWP_002964416.1. NZ_KN046823.1.

3D structure databases

ProteinModelPortaliQ2YQL5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ11274; CAJ11274; BAB1_1318.
GeneIDi3788641.
KEGGibmf:BAB1_1318.
PATRICi17845613. VBIBruMel86222_1371.

Phylogenomic databases

eggNOGiCOG1903.
HOGENOMiHOG000009126.
KOiK02188.
OMAiMMVHSKS.
OrthoDBiEOG6WX4M7.

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227.
BioCyciBABO359391:GKDV-1345-MONOMER.
BMEL359391:GJOQ-1345-MONOMER.

Family and domain databases

HAMAPiMF_00787. CbiD.
InterProiIPR002748. CbiD.
[Graphical view]
PfamiPF01888. CbiD. 1 hit.
[Graphical view]
PIRSFiPIRSF026782. CbiD. 1 hit.
SUPFAMiSSF111342. SSF111342. 1 hit.
TIGRFAMsiTIGR00312. cbiD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiCBID_BRUA2
AccessioniPrimary (citable) accession number: Q2YQL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: February 7, 2006
Last modified: July 22, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.