Reviewed, UniProtKB/Swiss-Prot Q2YQH8 (GLMM_BRUA2)

Names and origin

Protein names

Recommended name:
    Phosphoglucosamine mutase
    EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	BAB1_1702

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	451 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglucosamine mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 451	451	Phosphoglucosamine mutase HAMAP MF_01554		PRO_0000301287
Sites
	Active site	102	1	Phosphoserine intermediate By similarity
	Metal binding	102	1	Magnesium; via phosphate group By similarity
	Metal binding	243	1	Magnesium By similarity
	Metal binding	245	1	Magnesium By similarity
	Metal binding	247	1	Magnesium By similarity
Amino acid modifications
	Modified residue	102	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YQH8-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 430249DF47A17301	FASTA	451	48,541
	10 20 30 40 50 60 MTRKFFGTDG IRGQANSFPM TPEIAMKVGM AVGYIFRRKG QASRAVVGKD TRRSGYMLEK 70 80 90 100 110 120 ALVAGFTAAG MDVFLLGPIP TPAVAMLCRS LRADIGVMIS ASHNPFYDNG IKLFGPDGFK 130 140 150 160 170 180 LSDQIELQIE AMIEGDMTPF LASHGDVGRA KRVDGDIYRY IEFAKRTLPR NISLNGLRVV 190 200 210 220 230 240 VDCANGAGYK VAPAALWELG AEVITINNEP NGININEDCG STHPIGLMKK VHEVRADVGI 250 260 270 280 290 300 ALDGDADRVL LVDENGTVID GDQLMAVIAE SWAASNRLEG GGIVATVMSN LGLERFLADR 310 320 330 340 350 360 NLTLARTKVG DRYVVEHMRE HGFNVGGEQS GHIVLSDFAT TGDGLISALQ ILAVAQEQNK 370 380 390 400 410 420 PISDVCRKFQ PVPQLLKNVR TTGGKPLENK RVKSAIDEAK ERLGGQGRLV IRPSGTEPLI 430 440 450 RVMAEGDDRG LVEKVVNDII DVISSESSAA A

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040264 Genomic DNA. Translation: CAJ11658.1.
RefSeq	YP_415052.1.
3D structure databases
SMR	Q2YQH8. Positions 4-445.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YQH8.
Genome annotation databases
GeneID	3788724.
GenomeReviews	Gene locus BAB1_1702 in contig AM040264_GR.
KEGG	bmf:BAB1_1702.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
HOGENOM	HBG644964.
OMA	VHDRYIE.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_1702-MONOMER.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. A-D-PHexomutase_N. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
TIGRFAMs	TIGR01455. glmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_BRUA2

Accession

Primary (citable) accession number: Q2YQH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	February 7, 2006
Last modified:	February 9, 2010
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)