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Protein

Urease accessory protein UreD 2

Gene

ureD2

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.UniRule annotation
Disrupting the ure2 operon has no effect on urease activity or pathogen survival in BALB/c mice when administered orally.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Nickel insertion

Names & Taxonomyi

Protein namesi
Recommended name:
Urease accessory protein UreD 2UniRule annotation
Gene namesi
Name:ureD2UniRule annotation
Synonyms:ureD-2
Ordered Locus Names:BAB1_1382
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003404201 – 304Urease accessory protein UreD 2Add BLAST304

Interactioni

Subunit structurei

UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the UreD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000060675.
KOiK03190.
OMAiRALYWDE.

Family and domain databases

HAMAPiMF_01384. UreD. 1 hit.
InterProiIPR002669. UreD.
[Graphical view]
PfamiPF01774. UreD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YQD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKARELAN YQDEPEQLPT GSFGKNAFLR LGFERRPERT VLATLHRRAP
60 70 80 90 100
LIVQQALYWD EGMPTLPCVS IISNAGGILQ GDRYAIEIDL EPDTQAHVTT
110 120 130 140 150
QSATRIQEMD ANFATQTQTQ TITLGANSYL EYIPHPIIPH KHSRFVQQTE
160 170 180 190 200
VTIHPTATLI YSEVLMAGRK YYGTGELFHY DLFSSKFHAA HTDGTSLFTE
210 220 230 240 250
KFIVEPARGN VSRLGAMGSF HVFGNLILLT PKTHADRLFE TIDPVFDMDE
260 270 280 290 300
GIAWGASRLP NDAGLLFKVL GMESAPVRAA IRKIWEAARQ EVTGASLPEN

FLWA
Length:304
Mass (Da):33,915
Last modified:February 7, 2006 - v1
Checksum:i8373267BF3E80858
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11338.1.
RefSeqiWP_002964474.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ11338; CAJ11338; BAB1_1382.
GeneIDi3789050.
KEGGibmf:BAB1_1382.
PATRICi17845746. VBIBruMel86222_1436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11338.1.
RefSeqiWP_002964474.1. NZ_KN046823.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ11338; CAJ11338; BAB1_1382.
GeneIDi3789050.
KEGGibmf:BAB1_1382.
PATRICi17845746. VBIBruMel86222_1436.

Phylogenomic databases

HOGENOMiHOG000060675.
KOiK03190.
OMAiRALYWDE.

Family and domain databases

HAMAPiMF_01384. UreD. 1 hit.
InterProiIPR002669. UreD.
[Graphical view]
PfamiPF01774. UreD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiURED2_BRUA2
AccessioniPrimary (citable) accession number: Q2YQD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 7, 2006
Last modified: November 2, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.