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Protein

Cell cycle response regulator CtrA

Gene

ctrA

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential protein that plays a role in the control of cell division, possibly through the transcriptional regulation of ccrM, rpoD, pleC, minC and ftsZ genes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi124 – 223100OmpR/PhoB-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1647-MONOMER.
BMEL359391:GJOQ-1647-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell cycle response regulator CtrA
Gene namesi
Name:ctrA
Ordered Locus Names:BAB1_1614
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Cell cycle response regulator CtrAPRO_0000363196Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 5114-aspartylphosphatePROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ2YQA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 116115Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 OmpR/PhoB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034815.
KOiK13584.
OMAiVETNIVD.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YQA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLLIEDDS AIAQSIELML KSESFNVYTT DLGEEGIDLG KLYDYDIILL
60 70 80 90 100
DLNLPDMSGY EVLRTLRLSK VKTPILILSG MAGIEDKVRG LGFGADDYMT
110 120 130 140 150
KPFHKDELIA RIHAIVRRSK GHAQSVITTG DLVVNLDAKT VEVAGQRVHL
160 170 180 190 200
TGKEYQMLEL LSLRKGTTLT KEMFLNHLYG GMDEPELKII DVFICKLRKK
210 220 230
LDAVSGNQSY IETVWGRGYV LREPDAEMRE SA
Length:232
Mass (Da):26,066
Last modified:February 7, 2006 - v1
Checksum:i9177C2281EC76ACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11570.1.
RefSeqiWP_002964699.1. NZ_KN046823.1.
YP_414976.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ11570; CAJ11570; BAB1_1614.
GeneIDi3788674.
KEGGibmf:BAB1_1614.
PATRICi17846224. VBIBruMel86222_1673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11570.1.
RefSeqiWP_002964699.1. NZ_KN046823.1.
YP_414976.1. NC_007618.1.

3D structure databases

ProteinModelPortaliQ2YQA4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ11570; CAJ11570; BAB1_1614.
GeneIDi3788674.
KEGGibmf:BAB1_1614.
PATRICi17846224. VBIBruMel86222_1673.

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034815.
KOiK13584.
OMAiVETNIVD.
OrthoDBiEOG6G4VQG.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1647-MONOMER.
BMEL359391:GJOQ-1647-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.
  2. "The Brucella abortus CcrM DNA methyltransferase is essential for viability, and its overexpression attenuates intracellular replication in murine macrophages."
    Robertson G.T., Reisenauer A., Wright R., Jensen R.B., Jensen A., Shapiro L., Roop R.M. II
    J. Bacteriol. 182:3482-3489(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTIONAL CONTROL OF CCRM.

Entry informationi

Entry nameiCTRA_BRUA2
AccessioniPrimary (citable) accession number: Q2YQA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 7, 2006
Last modified: June 24, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.