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Q2YQ73 (NDVA_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Beta-(1-->2)glucan export ATP-binding/permease protein NdvA
EC=3.6.3.42
Gene names
Name:ndvA
Synonyms:cgt
Ordered Locus Names:BAB1_1017
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella ›

Protein attributes

Sequence length599 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in beta-(1-->2)glucan export. Its export to the periplasmic space is required to exert its action as a virulence factor. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation Probable. Ref.1

Catalytic activity

ATP + H2O + beta-glucan(In) = ADP + phosphate + beta-glucan(Out).

Subunit structure

Homodimer By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein Ref.1.

Domain

In NdvA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similarities

Belongs to the ABC transporter superfamily. Beta-(1-->2)glucan exporter (TC 3.A.1.108.1) family. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Ontologies

Keywords
   Biological processSugar transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processATP catabolic process

Inferred from electronic annotation. Source: GOC

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

beta-glucan-transporting ATPase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 599599Beta-(1-->2)glucan export ATP-binding/permease protein NdvA
PRO_0000290245

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane55 – 7521Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane248 – 26821Helical; Potential
Transmembrane276 – 29621Helical; Potential
Domain21 – 301281ABC transmembrane type-1
Domain335 – 569235ABC transporter
Nucleotide binding368 – 3758ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q2YQ73 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 2626C3220E57341C

FASTA59965,951
        10         20         30         40         50         60 
MSLLKIYWRA MQYLAVERTA TITMCVASVL VALVTLAEPV LFGRVIQSIS DKGDIFSPLL 

        70         80         90        100        110        120 
MWAALGGFNI MAAVFVARGA DRLAHRRRLG VMIDSYERLI TMPLAWHQKR GTSNALHTLI 

       130        140        150        160        170        180 
RATDSLFTLW LEFMRQHLTT VVALATLIPV AMTMDMRMSL VLIVLGVIYV MIGQLVMRKT 

       190        200        210        220        230        240 
KDGQAAVEKH HHKLFEHVSD TISNVSVVQS YNRIASETQA LRDYAKNLEN AQFPVLNWWA 

       250        260        270        280        290        300 
LASGLNRMAS TFSMVVVLVL GAYFVTKGQM RVGDVIAFIG FAQLMIGRLD QISAFINQTV 

       310        320        330        340        350        360 
TARAKLEEFF QMEDATADRQ EPENVADLND VKGDIVFDNV TYEFPNSGQG VYDVSFEVKP 

       370        380        390        400        410        420 
GQTVAIVGPT GAGKTTLINL LQRVFDPAAG RIMIDGTDTR TVSRRSLRHA IATVFQDAGL 

       430        440        450        460        470        480 
FNRSVEDNIR VGRANATHEE VHAAAKAAAA HDFILAKSEG YDTFVGERGS QLSGGERQRL 

       490        500        510        520        530        540 
AIARAILKDS PILVLDEATS ALDVETEEKV TQAVDELSHN RTTFIIAHRL STVRSADLVL 

       550        560        570        580        590 
FMDKGHLVES GSFNELAERG GRFSDLLRAG GLKLEDKQPK QPVVEGSNVM PFPVKGAVA

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of cgt, the Brucella abortus cyclic beta-1,2-glucan transporter gene, and its role in virulence."
Roset M.S., Ciocchini A.E., Ugalde R.A., Inon de Iannino N.
Infect. Immun. 72:2263-2271(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN BETA-(1->2)GLUCAN TRANSPORT, SUBCELLULAR LOCATION.
[2]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY237159 Genomic DNA. Translation: AAO84919.1.
AM040264 Genomic DNA. Translation: CAJ10973.1.
RefSeqYP_414423.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YQ73.
ModBaseSearch...

Protein-protein interaction databases

STRING359391.BAB1_1017.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ10973; CAJ10973; BAB1_1017.
GeneID3787677.
KEGGbmf:BAB1_1017.
PATRIC17844980. VBIBruMel86222_1062.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1132.
KOK06147.
OMANQISEAR.
ProtClustDBPRK13657.

Enzyme and pathway databases

BioCycBMEL359391:GJOQ-1036-MONOMER.

Family and domain databases

InterProIPR003593. AAA+_ATPase.
IPR017902. ABC_bGlucan_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR005896. NdvA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF90123. ABC_TM_1. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01192. chvA. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51317. NDVA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDVA_BRUA2
AccessionPrimary (citable) accession number: Q2YQ73
Secondary accession number(s): Q57DD0, Q844Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 7, 2006
Last modified: May 29, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names

SIMILARITY comments

Index of protein domains and families

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