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Q2YQ73

- NDVA_BRUA2

UniProt

Q2YQ73 - NDVA_BRUA2

Protein

Beta-(1-->2)glucan export ATP-binding/permease protein NdvA

Gene

ndvA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Involved in beta-(1-->2)glucan export. Its export to the periplasmic space is required to exert its action as a virulence factor. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation Probable.1 Publication

    Catalytic activityi

    ATP + H2O + beta-glucan(In) = ADP + phosphate + beta-glucan(Out).UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi368 – 3758ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. beta-glucan-transporting ATPase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Sugar transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-1036-MONOMER.
    BMEL359391:GJOQ-1036-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-(1-->2)glucan export ATP-binding/permease protein NdvAUniRule annotation (EC:3.6.3.42UniRule annotation)
    Gene namesi
    Name:ndvAUniRule annotation
    Synonyms:cgt
    Ordered Locus Names:BAB1_1017
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    Subcellular locationi

    Cell inner membrane 1 PublicationUniRule annotation; Multi-pass membrane protein 1 PublicationUniRule annotation

    GO - Cellular componenti

    1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 599599Beta-(1-->2)glucan export ATP-binding/permease protein NdvAPRO_0000290245Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_1017.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YQ73.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalUniRule annotationAdd
    BLAST
    Transmembranei55 – 7521HelicalUniRule annotationAdd
    BLAST
    Transmembranei156 – 17621HelicalUniRule annotationAdd
    BLAST
    Transmembranei248 – 26821HelicalUniRule annotationAdd
    BLAST
    Transmembranei276 – 29621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 301281ABC transmembrane type-1UniRule annotationAdd
    BLAST
    Domaini335 – 569235ABC transporterUniRule annotationAdd
    BLAST

    Domaini

    In NdvA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily. Beta-(1-->2)glucan exporter (TC 3.A.1.108.1) family. [View classification]UniRule annotation
    Contains 1 ABC transmembrane type-1 domain.UniRule annotation
    Contains 1 ABC transporter domain.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    KOiK06147.
    OMAiAVECYHH.
    OrthoDBiEOG6T7N3V.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR017902. ABC_bGlucan_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005896. NdvA.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    TIGRFAMsiTIGR01192. chvA. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51317. NDVA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YQ73-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLLKIYWRA MQYLAVERTA TITMCVASVL VALVTLAEPV LFGRVIQSIS    50
    DKGDIFSPLL MWAALGGFNI MAAVFVARGA DRLAHRRRLG VMIDSYERLI 100
    TMPLAWHQKR GTSNALHTLI RATDSLFTLW LEFMRQHLTT VVALATLIPV 150
    AMTMDMRMSL VLIVLGVIYV MIGQLVMRKT KDGQAAVEKH HHKLFEHVSD 200
    TISNVSVVQS YNRIASETQA LRDYAKNLEN AQFPVLNWWA LASGLNRMAS 250
    TFSMVVVLVL GAYFVTKGQM RVGDVIAFIG FAQLMIGRLD QISAFINQTV 300
    TARAKLEEFF QMEDATADRQ EPENVADLND VKGDIVFDNV TYEFPNSGQG 350
    VYDVSFEVKP GQTVAIVGPT GAGKTTLINL LQRVFDPAAG RIMIDGTDTR 400
    TVSRRSLRHA IATVFQDAGL FNRSVEDNIR VGRANATHEE VHAAAKAAAA 450
    HDFILAKSEG YDTFVGERGS QLSGGERQRL AIARAILKDS PILVLDEATS 500
    ALDVETEEKV TQAVDELSHN RTTFIIAHRL STVRSADLVL FMDKGHLVES 550
    GSFNELAERG GRFSDLLRAG GLKLEDKQPK QPVVEGSNVM PFPVKGAVA 599
    Length:599
    Mass (Da):65,951
    Last modified:February 7, 2006 - v1
    Checksum:i2626C3220E57341C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY237159 Genomic DNA. Translation: AAO84919.1.
    AM040264 Genomic DNA. Translation: CAJ10973.1.
    RefSeqiYP_414423.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ10973; CAJ10973; BAB1_1017.
    GeneIDi3787677.
    KEGGibmf:BAB1_1017.
    PATRICi17844980. VBIBruMel86222_1062.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY237159 Genomic DNA. Translation: AAO84919.1 .
    AM040264 Genomic DNA. Translation: CAJ10973.1 .
    RefSeqi YP_414423.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YQ73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_1017.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ10973 ; CAJ10973 ; BAB1_1017 .
    GeneIDi 3787677.
    KEGGi bmf:BAB1_1017.
    PATRICi 17844980. VBIBruMel86222_1062.

    Phylogenomic databases

    eggNOGi COG1132.
    KOi K06147.
    OMAi AVECYHH.
    OrthoDBi EOG6T7N3V.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-1036-MONOMER.
    BMEL359391:GJOQ-1036-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR017902. ABC_bGlucan_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005896. NdvA.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    TIGRFAMsi TIGR01192. chvA. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51317. NDVA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of cgt, the Brucella abortus cyclic beta-1,2-glucan transporter gene, and its role in virulence."
      Roset M.S., Ciocchini A.E., Ugalde R.A., Inon de Iannino N.
      Infect. Immun. 72:2263-2271(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN BETA-(1->2)GLUCAN TRANSPORT, SUBCELLULAR LOCATION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiNDVA_BRUA2
    AccessioniPrimary (citable) accession number: Q2YQ73
    Secondary accession number(s): Q57DD0, Q844Y8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3