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Q2YQ73

- NDVA_BRUA2

UniProt

Q2YQ73 - NDVA_BRUA2

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Protein

Beta-(1-->2)glucan export ATP-binding/permease protein NdvA

Gene

ndvA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in beta-(1-->2)glucan export. Its export to the periplasmic space is required to exert its action as a virulence factor. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).1 Publication

Catalytic activityi

ATP + H2O + beta-glucan(In) = ADP + phosphate + beta-glucan(Out).UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi368 – 3758ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. beta-glucan-transporting ATPase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sugar transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1036-MONOMER.
BMEL359391:GJOQ-1036-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-(1-->2)glucan export ATP-binding/permease protein NdvAUniRule annotation (EC:3.6.3.42UniRule annotation)
Gene namesi
Name:ndvAUniRule annotation
Synonyms:cgt
Ordered Locus Names:BAB1_1017
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Cell inner membrane 1 PublicationUniRule annotation; Multi-pass membrane protein 1 PublicationUniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalUniRule annotationAdd
BLAST
Transmembranei55 – 7521HelicalUniRule annotationAdd
BLAST
Transmembranei156 – 17621HelicalUniRule annotationAdd
BLAST
Transmembranei248 – 26821HelicalUniRule annotationAdd
BLAST
Transmembranei276 – 29621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Beta-(1-->2)glucan export ATP-binding/permease protein NdvAPRO_0000290245Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB1_1017.

Structurei

3D structure databases

ProteinModelPortaliQ2YQ73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 301281ABC transmembrane type-1UniRule annotationAdd
BLAST
Domaini335 – 569235ABC transporterUniRule annotationAdd
BLAST

Domaini

In NdvA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Beta-(1-->2)glucan exporter (TC 3.A.1.108.1) family. [View classification]UniRule annotation
Contains 1 ABC transmembrane type-1 domain.UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
KOiK06147.
OMAiAVECYHH.
OrthoDBiEOG6T7N3V.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR017902. ABC_bGlucan_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005896. NdvA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR01192. chvA. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51317. NDVA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YQ73-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLLKIYWRA MQYLAVERTA TITMCVASVL VALVTLAEPV LFGRVIQSIS
60 70 80 90 100
DKGDIFSPLL MWAALGGFNI MAAVFVARGA DRLAHRRRLG VMIDSYERLI
110 120 130 140 150
TMPLAWHQKR GTSNALHTLI RATDSLFTLW LEFMRQHLTT VVALATLIPV
160 170 180 190 200
AMTMDMRMSL VLIVLGVIYV MIGQLVMRKT KDGQAAVEKH HHKLFEHVSD
210 220 230 240 250
TISNVSVVQS YNRIASETQA LRDYAKNLEN AQFPVLNWWA LASGLNRMAS
260 270 280 290 300
TFSMVVVLVL GAYFVTKGQM RVGDVIAFIG FAQLMIGRLD QISAFINQTV
310 320 330 340 350
TARAKLEEFF QMEDATADRQ EPENVADLND VKGDIVFDNV TYEFPNSGQG
360 370 380 390 400
VYDVSFEVKP GQTVAIVGPT GAGKTTLINL LQRVFDPAAG RIMIDGTDTR
410 420 430 440 450
TVSRRSLRHA IATVFQDAGL FNRSVEDNIR VGRANATHEE VHAAAKAAAA
460 470 480 490 500
HDFILAKSEG YDTFVGERGS QLSGGERQRL AIARAILKDS PILVLDEATS
510 520 530 540 550
ALDVETEEKV TQAVDELSHN RTTFIIAHRL STVRSADLVL FMDKGHLVES
560 570 580 590
GSFNELAERG GRFSDLLRAG GLKLEDKQPK QPVVEGSNVM PFPVKGAVA
Length:599
Mass (Da):65,951
Last modified:February 7, 2006 - v1
Checksum:i2626C3220E57341C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237159 Genomic DNA. Translation: AAO84919.1.
AM040264 Genomic DNA. Translation: CAJ10973.1.
RefSeqiYP_414423.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ10973; CAJ10973; BAB1_1017.
GeneIDi3787677.
KEGGibmf:BAB1_1017.
PATRICi17844980. VBIBruMel86222_1062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237159 Genomic DNA. Translation: AAO84919.1 .
AM040264 Genomic DNA. Translation: CAJ10973.1 .
RefSeqi YP_414423.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YQ73.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_1017.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ10973 ; CAJ10973 ; BAB1_1017 .
GeneIDi 3787677.
KEGGi bmf:BAB1_1017.
PATRICi 17844980. VBIBruMel86222_1062.

Phylogenomic databases

eggNOGi COG1132.
KOi K06147.
OMAi AVECYHH.
OrthoDBi EOG6T7N3V.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-1036-MONOMER.
BMEL359391:GJOQ-1036-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR017902. ABC_bGlucan_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005896. NdvA.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsi TIGR01192. chvA. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51317. NDVA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of cgt, the Brucella abortus cyclic beta-1,2-glucan transporter gene, and its role in virulence."
    Roset M.S., Ciocchini A.E., Ugalde R.A., Inon de Iannino N.
    Infect. Immun. 72:2263-2271(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN BETA-(1->2)GLUCAN TRANSPORT, SUBCELLULAR LOCATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiNDVA_BRUA2
AccessioniPrimary (citable) accession number: Q2YQ73
Secondary accession number(s): Q57DD0, Q844Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 7, 2006
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3