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Protein

NAD(P)H dehydrogenase (quinone)

Gene

BAB1_1070

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12NAD(P)UniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Binding sitei134FMNUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 14FMNUniRule annotation5
Nucleotide bindingi110 – 162FMNUniRule annotationAdd BLAST53

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H dehydrogenase (quinone)UniRule annotation (EC:1.6.5.2UniRule annotation)
Alternative name(s):
Flavoprotein WrbA
NAD(P)H:quinone oxidoreductaseUniRule annotation
Short name:
NQOUniRule annotation
Gene namesi
Ordered Locus Names:BAB1_1070
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002910071 – 199NAD(P)H dehydrogenase (quinone)Add BLAST199

Proteomic databases

PRIDEiQ2YQ23.

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 9Combined sources7
Beta strandi11 – 13Combined sources3
Helixi14 – 27Combined sources14
Turni28 – 30Combined sources3
Beta strandi32 – 37Combined sources6
Turni45 – 47Combined sources3
Beta strandi48 – 51Combined sources4
Beta strandi56 – 58Combined sources3
Helixi63 – 68Combined sources6
Beta strandi70 – 79Combined sources10
Helixi85 – 91Combined sources7
Turni92 – 94Combined sources3
Helixi95 – 100Combined sources6
Turni101 – 105Combined sources5
Beta strandi107 – 113Combined sources7
Helixi122 – 133Combined sources12
Turni134 – 136Combined sources3
Helixi144 – 157Combined sources14
Helixi177 – 198Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5F4BX-ray2.50A/B1-199[»]
5F51X-ray2.53A1-199[»]
ProteinModelPortaliQ2YQ23.
SMRiQ2YQ23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 190Flavodoxin-likeUniRule annotationAdd BLAST187

Sequence similaritiesi

Belongs to the WrbA family.UniRule annotation
Contains 1 flavodoxin-like domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000030539.
KOiK03809.
OMAiWMKGALV.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YQ23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKMLVLYYS AYGYMEQMAK AAAEGAREGG AEVTLKRVPE LVPEEVAKAS
60 70 80 90 100
HYKIDQEVPI ATPGELADYD AIIIGTATRY GMMASQMKNF LDQTGGLWAK
110 120 130 140 150
GALINKVGSV MVSTATQHGG AELALISTQW QMQHHGMIIV PLSYAYREQM
160 170 180 190
GNDVVRGGAP YGMTTTADGD GSRQPSAQEL DGARFQGRRV AEITAKLHG
Length:199
Mass (Da):21,442
Last modified:February 7, 2006 - v1
Checksum:i1E70DC2A51E5A676
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11026.1.
RefSeqiWP_002964168.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ11026; CAJ11026; BAB1_1070.
GeneIDi3787724.
KEGGibmf:BAB1_1070.
PATRICi17845082. VBIBruMel86222_1113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11026.1.
RefSeqiWP_002964168.1. NZ_KN046823.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5F4BX-ray2.50A/B1-199[»]
5F51X-ray2.53A1-199[»]
ProteinModelPortaliQ2YQ23.
SMRiQ2YQ23.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2YQ23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ11026; CAJ11026; BAB1_1070.
GeneIDi3787724.
KEGGibmf:BAB1_1070.
PATRICi17845082. VBIBruMel86222_1113.

Phylogenomic databases

HOGENOMiHOG000030539.
KOiK03809.
OMAiWMKGALV.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNQOR_BRUA2
AccessioniPrimary (citable) accession number: Q2YQ23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: February 7, 2006
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.