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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1138-MONOMER.
BMEL359391:GJOQ-1138-MONOMER.
UniPathwayiUPA00392.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:BAB1_1116
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363S-adenosylmethionine:tRNA ribosyltransferase-isomerasePRO_0000231322Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2YPY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004401.
KOiK07568.
OMAiYGDAMFL.

Family and domain databases

HAMAPiMF_00113. QueA. 1 hit.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 1 hit.
TIGRFAMsiTIGR00113. queA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YPY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVDLFDFDL PEERIALRPV EPRDHAKLLH VRPGEPFEDR HVYDLPDLLQ
60 70 80 90 100
PGDALVFNDT KVIPAQLEGM RERTGNISQV SATLHMRVGP DRWKAFLRPA
110 120 130 140 150
KRVKEGDRIR FGHSGTSCFL GTLDATVAEK GDSGEALLVF DLSGAVLDEA
160 170 180 190 200
IAAVGHIPLP PYIASKRPED ERDRKDYQTV YAREEGAVAA PTAGLHFTPD
210 220 230 240 250
LLEKIKARGI EEHFVTLHVG AGTFLPVKAD DTGDHKMHAE IGHVSQRTAS
260 270 280 290 300
ALNAVHERGG RIICVGTTSL RLIESATGED GVVRPWSGAT DIFITPGYRF
310 320 330 340 350
RAVDLLMTNF HLPRSTLFML VSAFSGLDTM HAAYNYAIAD GYRFYSYGDA
360
SLLERIDHDR HSA
Length:363
Mass (Da):40,174
Last modified:February 7, 2006 - v1
Checksum:i972A658AA3E91CFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11072.1.
RefSeqiWP_002964220.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ11072; CAJ11072; BAB1_1116.
GeneIDi3788890.
KEGGibmf:BAB1_1116.
PATRICi17845190. VBIBruMel86222_1165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11072.1.
RefSeqiWP_002964220.1. NZ_KN046823.1.

3D structure databases

ProteinModelPortaliQ2YPY7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ11072; CAJ11072; BAB1_1116.
GeneIDi3788890.
KEGGibmf:BAB1_1116.
PATRICi17845190. VBIBruMel86222_1165.

Phylogenomic databases

HOGENOMiHOG000004401.
KOiK07568.
OMAiYGDAMFL.

Enzyme and pathway databases

UniPathwayiUPA00392.
BioCyciBABO359391:GKDV-1138-MONOMER.
BMEL359391:GJOQ-1138-MONOMER.

Family and domain databases

HAMAPiMF_00113. QueA. 1 hit.
InterProiIPR003699. QueA.
[Graphical view]
PfamiPF02547. Queuosine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF111337. SSF111337. 1 hit.
TIGRFAMsiTIGR00113. queA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQUEA_BRUA2
AccessioniPrimary (citable) accession number: Q2YPY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 7, 2006
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.