Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q2YPY4 (COAD_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphopantetheine adenylyltransferase

EC=2.7.7.3
Alternative name(s):
Dephospho-CoA pyrophosphorylase
Pantetheine-phosphate adenylyltransferase
Short name=PPAT
Gene names
Name:coaD
Ordered Locus Names:BAB1_1119
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length164 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity. HAMAP MF_00151

Catalytic activity

ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP MF_00151

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP MF_00151

Subunit structure

Homohexamer By similarity. HAMAP MF_00151

Subcellular location

Cytoplasm By similarity HAMAP MF_00151.

Sequence similarities

Belongs to the bacterial CoaD family.

Ontologies

Keywords
   Biological processCoenzyme A biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcoenzyme A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantetheine-phosphate adenylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 164164Phosphopantetheine adenylyltransferase HAMAP MF_00151
PRO_1000011100

Sequences

Sequence LengthMass (Da)Tools
Q2YPY4 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 73787866A6C89A5A

FASTA16417,399
        10         20         30         40         50         60 
MTIAIYAGSF DPVTNGHIDV LKGALRLADQ VIVAIGMHPG KKPLFSFDER VALIEASAKA 

        70         80         90        100        110        120 
VLHKDAARVS VIAFDGLVID AARKHGAQLM VRGLRDGTDL DYEMQMAGMN GTMAPELQTV 

       130        140        150        160 
FLPADPAVRT ITATLVRQIA SMGGDIKPFV PVAVAAALNT KFKS 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ11075.1.
RefSeqYP_414512.1. NC_007618.1.

3D structure databases

HSSPHSSP built from PDB template 1VLH based on UniProtKB Q9WZK0.
ProteinModelPortalQ2YPY4.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2YPY4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3788657.
GenomeReviewsGene locus BAB1_1119 in contig AM040264_GR.
KEGGbmf:BAB1_1119.
PATRIC17845196. VBIBruMel86222_1168.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0669.
HOGENOMHBG288308.
OMAAMSDFEY.
ProtClustDBPRK00168.

Enzyme and pathway databases

BioCycBMEL359391:BAB1_1119-MONOMER.

Family and domain databases

HAMAPMF_00151. PPAT_bact.
[Tree]
InterProIPR004821. Cyt_trans-rel.
IPR004820. Cytidylyltransf.
IPR001980. LPS_biosynth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK00954.
PfamPF01467. CTP_transf_2. 1 hit.
[Graphical view]
PRINTSPR01020. LPSBIOSNTHSS.
TIGRFAMsTIGR01510. CoaD_prev_kdtB. 1 hit.
TIGR00125. Cyt_tran_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOAD_BRUA2
AccessionPrimary (citable) accession number: Q2YPY4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families