Reviewed,
UniProtKB/Swiss-Prot Q2YPY4 (COAD_BRUA2)
Last modified
February 9, 2010.
Version 28.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Phosphopantetheine adenylyltransferase EC=2.7.7.3 Alternative name(s): Pantetheine-phosphate adenylyltransferase Short name=PPAT Dephospho-CoA pyrophosphorylase | ||||
| Gene names |
| ||||
| Organism | Brucella abortus (strain 2308) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 359391 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 164 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity. HAMAP MF_00151 |
| Catalytic activity | ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP MF_00151 |
| Pathway | Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP MF_00151 |
| Subunit structure | Homohexamer By similarity. HAMAP MF_00151 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00151. |
| Sequence similarities | Belongs to the bacterial coaD family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Coenzyme A biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Nucleotidyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantetheine-phosphate adenylyltransferase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 164 | 164 | Phosphopantetheine adenylyltransferase HAMAP MF_00151 | PRO_1000011100 | |||
Sequences
| ||||||||||||||||||
References
| [1] | "Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AM040264 Genomic DNA. Translation: CAJ11075.1. |
| RefSeq | YP_414512.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1VLH based on UniProtKB Q9WZK0. |
| SMR | Q2YPY4. Positions 2-163. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2YPY4. |
Genome annotation databases | |
| GeneID | 3788657. |
| GenomeReviews | Gene locus BAB1_1119 in contig AM040264_GR. |
| KEGG | bmf:BAB1_1119. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0669. |
| HOGENOM | HBG288308. |
| OMA | VRQIAAM. |
Enzyme and pathway databases | |
| BioCyc | BMEL359391:BAB1_1119-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00151. PPAT_bact. [Tree] |
| InterPro | IPR004821. Cyt_trans_rel. IPR004820. Cytidylyltransf. IPR001980. LPS_biosynth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit. |
| Pfam | PF01467. CTP_transf_2. 1 hit. [Graphical view] |
| PRINTS | PR01020. LPSBIOSNTHSS. |
| TIGRFAMs | TIGR01510. coaD_prev_kdtB. 1 hit. TIGR00125. cyt_tran_rel. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | COAD_BRUA2 | ||||||||
| Accession | Primary (citable) accession number: Q2YPY4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Brucella abortus strain 2308 Brucella abortus (strain 2308): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


