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Q2YPX5

- UVRA_BRUA2

UniProt

Q2YPX5 - UVRA_BRUA2

Protein

UvrABC system protein A

Gene

uvrA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi34 – 418ATPUniRule annotation
    Nucleotide bindingi663 – 6708ATPUniRule annotation
    Zinc fingeri762 – 78827C4-typeUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. DNA binding Source: UniProtKB-HAMAP
    4. excinuclease ABC activity Source: UniProtKB-HAMAP
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. nucleotide-excision repair Source: UniProtKB-HAMAP
    2. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Excision nuclease

    Keywords - Biological processi

    DNA damage, DNA excision, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-1150-MONOMER.
    BMEL359391:GJOQ-1150-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UvrABC system protein AUniRule annotation
    Short name:
    UvrA proteinUniRule annotation
    Alternative name(s):
    Excinuclease ABC subunit AUniRule annotation
    Gene namesi
    Name:uvrAUniRule annotation
    Ordered Locus Names:BAB1_1128
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. excinuclease repair complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 974974UvrABC system protein APRO_0000093039Add
    BLAST

    Proteomic databases

    PRIDEiQ2YPX5.

    Interactioni

    Subunit structurei

    Forms a heterotetramer with UvrB during the search for lesions.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_1128.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YPX5.
    SMRiQ2YPX5. Positions 7-968.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini331 – 610280ABC transporter 1UniRule annotationAdd
    BLAST
    Domaini630 – 959330ABC transporter 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily. UvrA family.UniRule annotation
    Contains 2 ABC transporter domains.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri762 – 78827C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0178.
    HOGENOMiHOG000050448.
    KOiK03701.
    OMAiEGVLNNM.
    OrthoDBiEOG6QK4PS.

    Family and domain databases

    Gene3Di3.30.1490.20. 2 hits.
    3.40.50.300. 4 hits.
    HAMAPiMF_00205. UvrA.
    InterProiIPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR013815. ATP_grasp_subdomain_1.
    IPR027417. P-loop_NTPase.
    IPR004602. UvrA.
    [Graphical view]
    PfamiPF00005. ABC_tran. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 3 hits.
    TIGRFAMsiTIGR00630. uvra. 1 hit.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YPX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDQKFISIR GAREHNLKNV DLDLPRDKLI VMTGLSGSGK SSLAFDTIYA    50
    EGQRRYVESL SAYARQFLEM MQKPDVDQID GLSPAISIEQ KTTSRNPRST 100
    VGTVTEIYDY MRLLFARVGI PYSPATGLPI ESQTVSQMVD RVIALEEGTR 150
    LYILAPIVRG RKGEYRKELA ELQKKGFQRV KVDGTFYEIA DVPPLDKKYK 200
    HDIDVVVDRV VVRPDLSTRL ADSLETCLKL ADGLAIAEFA DKPLPVGETA 250
    EGGSANKSAN ETHERILFSE KFACPVSGFT IPEIEPRLFS FNNPFGACPT 300
    CDGLGTQQAI DPNLIIPDES AALKDGAVAP WARSSSPYYN QTLEALGKAY 350
    GFKVSARWSE LSEEARQAIL YGTKGREITF HYDDGLRSYQ TTKPFEGVIP 400
    NLERRWKETD SAWSREEIER FMASTPCPAC NGYRLKPEAL SVKIGKKHIG 450
    EITEMSIRKA DAWFRDIDGS FNEKQREIAA RILKAIRERL QFLNNVGLDY 500
    LTLARNSGTL SGGESQRIRL ASQIGSGLTG VLYVLDEPSI GLHQRDNARL 550
    LDTLRHLRDL GNTVIVVEHD EDAILTADYV VDIGPAAGVH GGKVIAQGSP 600
    QDIMANTNSL TGKYLSGAME VAVPAERRKI SKTKRLRVVG ARGNNLKNVS 650
    ADIPLGTFTA VTGVSGGGKS TFLIETLFKA ASRRIMGSRE HPAEHDRIEG 700
    LEFLDKVIDI DQSPIGRTPR SNPATYTGAF TPIRDWFAGL PEAKARGYQP 750
    GRFSFNVKGG RCEACQGDGV IKIEMHFLPD VYVTCDVCHG KRYNRETLDV 800
    LFKGKSIADV LDMTVEEGAE FFSAVPAVRD KLETLVKVGL GYIKVGQQAT 850
    TLSGGEAQRV KLAKELSRRA TGRTLYILDE PTTGLHFHDV AKLLEVLHEL 900
    VEQGNTVVVI EHNLEVIKTA DWVIDLGPEG GDGGGEIVAV GRPEDIVQEK 950
    RSYTGQFLKE LLERRPKRSS QAAE 974
    Length:974
    Mass (Da):107,423
    Last modified:December 20, 2005 - v1
    Checksum:i15F7C2BADB7B3127
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11084.1.
    L10843 Unassigned DNA. Translation: AAA16817.1.
    PIRiI40351.
    RefSeqiYP_414521.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ11084; CAJ11084; BAB1_1128.
    GeneIDi3787776.
    KEGGibmf:BAB1_1128.
    PATRICi17845214. VBIBruMel86222_1177.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11084.1 .
    L10843 Unassigned DNA. Translation: AAA16817.1 .
    PIRi I40351.
    RefSeqi YP_414521.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YPX5.
    SMRi Q2YPX5. Positions 7-968.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_1128.

    Proteomic databases

    PRIDEi Q2YPX5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ11084 ; CAJ11084 ; BAB1_1128 .
    GeneIDi 3787776.
    KEGGi bmf:BAB1_1128.
    PATRICi 17845214. VBIBruMel86222_1177.

    Phylogenomic databases

    eggNOGi COG0178.
    HOGENOMi HOG000050448.
    KOi K03701.
    OMAi EGVLNNM.
    OrthoDBi EOG6QK4PS.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-1150-MONOMER.
    BMEL359391:GJOQ-1150-MONOMER.

    Miscellaneous databases

    PROi Q2YPX5.

    Family and domain databases

    Gene3Di 3.30.1490.20. 2 hits.
    3.40.50.300. 4 hits.
    HAMAPi MF_00205. UvrA.
    InterProi IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR013815. ATP_grasp_subdomain_1.
    IPR027417. P-loop_NTPase.
    IPR004602. UvrA.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 3 hits.
    TIGRFAMsi TIGR00630. uvra. 1 hit.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.
    2. "Isolation of Brucella abortus ssb and uvrA genes from a genomic library by use of lymphocytes as probes."
      Zhu Y., Oliveira S.C., Splitter G.A.
      Infect. Immun. 61:5339-5344(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-227.

    Entry informationi

    Entry nameiUVRA_BRUA2
    AccessioniPrimary (citable) accession number: Q2YPX5
    Secondary accession number(s): Q07433, Q57D33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3