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Q2YPX5 (UVRA_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UvrABC system protein A
Short name=UvrA protein
Alternative name(s):
Excinuclease ABC subunit A
Gene names
Name:uvrA
Ordered Locus Names:BAB1_1128
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella ›

Protein attributes

Sequence length974 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate By similarity. HAMAP-Rule MF_00205

Subunit structure

Forms a heterotetramer with UvrB during the search for lesions By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ABC transporter superfamily. UvrA family.

Contains 2 ABC transporter domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 974974UvrABC system protein A HAMAP-Rule MF_00205
PRO_0000093039

Regions

Domain341 – 616276ABC transporter 1
Domain625 – 959335ABC transporter 2
Nucleotide binding34 – 418ATP Potential
Nucleotide binding663 – 6708ATP Potential
Zinc finger762 – 78827C4-type HAMAP-Rule MF_00205

Sequences

Sequence LengthMass (Da)Tools
Q2YPX5 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 15F7C2BADB7B3127

FASTA974107,423
        10         20         30         40         50         60 
MSDQKFISIR GAREHNLKNV DLDLPRDKLI VMTGLSGSGK SSLAFDTIYA EGQRRYVESL 

        70         80         90        100        110        120 
SAYARQFLEM MQKPDVDQID GLSPAISIEQ KTTSRNPRST VGTVTEIYDY MRLLFARVGI 

       130        140        150        160        170        180 
PYSPATGLPI ESQTVSQMVD RVIALEEGTR LYILAPIVRG RKGEYRKELA ELQKKGFQRV 

       190        200        210        220        230        240 
KVDGTFYEIA DVPPLDKKYK HDIDVVVDRV VVRPDLSTRL ADSLETCLKL ADGLAIAEFA 

       250        260        270        280        290        300 
DKPLPVGETA EGGSANKSAN ETHERILFSE KFACPVSGFT IPEIEPRLFS FNNPFGACPT 

       310        320        330        340        350        360 
CDGLGTQQAI DPNLIIPDES AALKDGAVAP WARSSSPYYN QTLEALGKAY GFKVSARWSE 

       370        380        390        400        410        420 
LSEEARQAIL YGTKGREITF HYDDGLRSYQ TTKPFEGVIP NLERRWKETD SAWSREEIER 

       430        440        450        460        470        480 
FMASTPCPAC NGYRLKPEAL SVKIGKKHIG EITEMSIRKA DAWFRDIDGS FNEKQREIAA 

       490        500        510        520        530        540 
RILKAIRERL QFLNNVGLDY LTLARNSGTL SGGESQRIRL ASQIGSGLTG VLYVLDEPSI 

       550        560        570        580        590        600 
GLHQRDNARL LDTLRHLRDL GNTVIVVEHD EDAILTADYV VDIGPAAGVH GGKVIAQGSP 

       610        620        630        640        650        660 
QDIMANTNSL TGKYLSGAME VAVPAERRKI SKTKRLRVVG ARGNNLKNVS ADIPLGTFTA 

       670        680        690        700        710        720 
VTGVSGGGKS TFLIETLFKA ASRRIMGSRE HPAEHDRIEG LEFLDKVIDI DQSPIGRTPR 

       730        740        750        760        770        780 
SNPATYTGAF TPIRDWFAGL PEAKARGYQP GRFSFNVKGG RCEACQGDGV IKIEMHFLPD 

       790        800        810        820        830        840 
VYVTCDVCHG KRYNRETLDV LFKGKSIADV LDMTVEEGAE FFSAVPAVRD KLETLVKVGL 

       850        860        870        880        890        900 
GYIKVGQQAT TLSGGEAQRV KLAKELSRRA TGRTLYILDE PTTGLHFHDV AKLLEVLHEL 

       910        920        930        940        950        960 
VEQGNTVVVI EHNLEVIKTA DWVIDLGPEG GDGGGEIVAV GRPEDIVQEK RSYTGQFLKE 

       970 
LLERRPKRSS QAAE

« Hide

References

« Hide 'large scale' references
[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.
[2]"Isolation of Brucella abortus ssb and uvrA genes from a genomic library by use of lymphocytes as probes."
Zhu Y., Oliveira S.C., Splitter G.A.
Infect. Immun. 61:5339-5344(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-227.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM040264 Genomic DNA. Translation: CAJ11084.1.
L10843 Unassigned DNA. Translation: AAA16817.1.
PIRI40351.
RefSeqYP_414521.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YPX5.
SMRQ2YPX5. Positions 7-968.
ModBaseSearch...

Protein-protein interaction databases

STRING359391.BAB1_1128.

Proteomic databases

PRIDEQ2YPX5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ11084; CAJ11084; BAB1_1128.
GeneID3787776.
KEGGbmf:BAB1_1128.
PATRIC17845214. VBIBruMel86222_1177.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0178.
HOGENOMHOG000050448.
KOK03701.
OMAGAIKGWD.
ProtClustDBPRK00349.

Enzyme and pathway databases

BioCycBMEL359391:GJOQ-1150-MONOMER.

Family and domain databases

Gene3D3.30.1490.20. 2 hits.
HAMAPMF_00205. UvrA.
InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR004602. UvrA.
[Graphical view]
PfamPF00005. ABC_tran. 2 hits.
[Graphical view]
TIGRFAMsTIGR00630. uvra. 1 hit.
PROSITEPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRA_BRUA2
AccessionPrimary (citable) accession number: Q2YPX5
Secondary accession number(s): Q07433, Q57D33
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 20, 2005
Last modified: May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names

SIMILARITY comments

Index of protein domains and families

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