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Q2YPX5

- UVRA_BRUA2

UniProt

Q2YPX5 - UVRA_BRUA2

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Protein

UvrABC system protein A

Gene

uvrA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 418ATPUniRule annotation
Nucleotide bindingi663 – 6708ATPUniRule annotation
Zinc fingeri762 – 78827C4-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. DNA binding Source: UniProtKB-HAMAP
  4. excinuclease ABC activity Source: UniProtKB-HAMAP
  5. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1150-MONOMER.
BMEL359391:GJOQ-1150-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein AUniRule annotation
Short name:
UvrA proteinUniRule annotation
Alternative name(s):
Excinuclease ABC subunit AUniRule annotation
Gene namesi
Name:uvrAUniRule annotation
Ordered Locus Names:BAB1_1128
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 974974UvrABC system protein APRO_0000093039Add
BLAST

Proteomic databases

PRIDEiQ2YPX5.

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB1_1128.

Structurei

3D structure databases

ProteinModelPortaliQ2YPX5.
SMRiQ2YPX5. Positions 7-968.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini331 – 610280ABC transporter 1UniRule annotationAdd
BLAST
Domaini630 – 959330ABC transporter 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. UvrA family.UniRule annotation
Contains 2 ABC transporter domains.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri762 – 78827C4-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0178.
HOGENOMiHOG000050448.
KOiK03701.
OMAiEGVLNNM.
OrthoDBiEOG6QK4PS.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPiMF_00205. UvrA.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YPX5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDQKFISIR GAREHNLKNV DLDLPRDKLI VMTGLSGSGK SSLAFDTIYA
60 70 80 90 100
EGQRRYVESL SAYARQFLEM MQKPDVDQID GLSPAISIEQ KTTSRNPRST
110 120 130 140 150
VGTVTEIYDY MRLLFARVGI PYSPATGLPI ESQTVSQMVD RVIALEEGTR
160 170 180 190 200
LYILAPIVRG RKGEYRKELA ELQKKGFQRV KVDGTFYEIA DVPPLDKKYK
210 220 230 240 250
HDIDVVVDRV VVRPDLSTRL ADSLETCLKL ADGLAIAEFA DKPLPVGETA
260 270 280 290 300
EGGSANKSAN ETHERILFSE KFACPVSGFT IPEIEPRLFS FNNPFGACPT
310 320 330 340 350
CDGLGTQQAI DPNLIIPDES AALKDGAVAP WARSSSPYYN QTLEALGKAY
360 370 380 390 400
GFKVSARWSE LSEEARQAIL YGTKGREITF HYDDGLRSYQ TTKPFEGVIP
410 420 430 440 450
NLERRWKETD SAWSREEIER FMASTPCPAC NGYRLKPEAL SVKIGKKHIG
460 470 480 490 500
EITEMSIRKA DAWFRDIDGS FNEKQREIAA RILKAIRERL QFLNNVGLDY
510 520 530 540 550
LTLARNSGTL SGGESQRIRL ASQIGSGLTG VLYVLDEPSI GLHQRDNARL
560 570 580 590 600
LDTLRHLRDL GNTVIVVEHD EDAILTADYV VDIGPAAGVH GGKVIAQGSP
610 620 630 640 650
QDIMANTNSL TGKYLSGAME VAVPAERRKI SKTKRLRVVG ARGNNLKNVS
660 670 680 690 700
ADIPLGTFTA VTGVSGGGKS TFLIETLFKA ASRRIMGSRE HPAEHDRIEG
710 720 730 740 750
LEFLDKVIDI DQSPIGRTPR SNPATYTGAF TPIRDWFAGL PEAKARGYQP
760 770 780 790 800
GRFSFNVKGG RCEACQGDGV IKIEMHFLPD VYVTCDVCHG KRYNRETLDV
810 820 830 840 850
LFKGKSIADV LDMTVEEGAE FFSAVPAVRD KLETLVKVGL GYIKVGQQAT
860 870 880 890 900
TLSGGEAQRV KLAKELSRRA TGRTLYILDE PTTGLHFHDV AKLLEVLHEL
910 920 930 940 950
VEQGNTVVVI EHNLEVIKTA DWVIDLGPEG GDGGGEIVAV GRPEDIVQEK
960 970
RSYTGQFLKE LLERRPKRSS QAAE
Length:974
Mass (Da):107,423
Last modified:December 20, 2005 - v1
Checksum:i15F7C2BADB7B3127
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11084.1.
L10843 Unassigned DNA. Translation: AAA16817.1.
PIRiI40351.
RefSeqiYP_414521.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ11084; CAJ11084; BAB1_1128.
GeneIDi3787776.
KEGGibmf:BAB1_1128.
PATRICi17845214. VBIBruMel86222_1177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11084.1 .
L10843 Unassigned DNA. Translation: AAA16817.1 .
PIRi I40351.
RefSeqi YP_414521.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YPX5.
SMRi Q2YPX5. Positions 7-968.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_1128.

Proteomic databases

PRIDEi Q2YPX5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ11084 ; CAJ11084 ; BAB1_1128 .
GeneIDi 3787776.
KEGGi bmf:BAB1_1128.
PATRICi 17845214. VBIBruMel86222_1177.

Phylogenomic databases

eggNOGi COG0178.
HOGENOMi HOG000050448.
KOi K03701.
OMAi EGVLNNM.
OrthoDBi EOG6QK4PS.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-1150-MONOMER.
BMEL359391:GJOQ-1150-MONOMER.

Miscellaneous databases

PROi Q2YPX5.

Family and domain databases

Gene3Di 3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPi MF_00205. UvrA.
InterProi IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view ]
Pfami PF00005. ABC_tran. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00630. uvra. 1 hit.
PROSITEi PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.
  2. "Isolation of Brucella abortus ssb and uvrA genes from a genomic library by use of lymphocytes as probes."
    Zhu Y., Oliveira S.C., Splitter G.A.
    Infect. Immun. 61:5339-5344(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-227.

Entry informationi

Entry nameiUVRA_BRUA2
AccessioniPrimary (citable) accession number: Q2YPX5
Secondary accession number(s): Q07433, Q57D33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3