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Protein

UvrABC system protein A

Gene

uvrA

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 41ATPUniRule annotation8
Nucleotide bindingi663 – 670ATPUniRule annotation8
Zinc fingeri762 – 788C4-typeUniRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein AUniRule annotation
Short name:
UvrA proteinUniRule annotation
Alternative name(s):
Excinuclease ABC subunit AUniRule annotation
Gene namesi
Name:uvrAUniRule annotation
Ordered Locus Names:BAB1_1128
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000930391 – 974UvrABC system protein AAdd BLAST974

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2YPX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini331 – 610ABC transporter 1UniRule annotationAdd BLAST280
Domaini630 – 959ABC transporter 2UniRule annotationAdd BLAST330

Sequence similaritiesi

Belongs to the ABC transporter superfamily. UvrA family.UniRule annotation
Contains 2 ABC transporter domains.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri762 – 788C4-typeUniRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000050448.
KOiK03701.
OMAiGAIKGWD.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPiMF_00205. UvrA. 1 hit.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YPX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQKFISIR GAREHNLKNV DLDLPRDKLI VMTGLSGSGK SSLAFDTIYA
60 70 80 90 100
EGQRRYVESL SAYARQFLEM MQKPDVDQID GLSPAISIEQ KTTSRNPRST
110 120 130 140 150
VGTVTEIYDY MRLLFARVGI PYSPATGLPI ESQTVSQMVD RVIALEEGTR
160 170 180 190 200
LYILAPIVRG RKGEYRKELA ELQKKGFQRV KVDGTFYEIA DVPPLDKKYK
210 220 230 240 250
HDIDVVVDRV VVRPDLSTRL ADSLETCLKL ADGLAIAEFA DKPLPVGETA
260 270 280 290 300
EGGSANKSAN ETHERILFSE KFACPVSGFT IPEIEPRLFS FNNPFGACPT
310 320 330 340 350
CDGLGTQQAI DPNLIIPDES AALKDGAVAP WARSSSPYYN QTLEALGKAY
360 370 380 390 400
GFKVSARWSE LSEEARQAIL YGTKGREITF HYDDGLRSYQ TTKPFEGVIP
410 420 430 440 450
NLERRWKETD SAWSREEIER FMASTPCPAC NGYRLKPEAL SVKIGKKHIG
460 470 480 490 500
EITEMSIRKA DAWFRDIDGS FNEKQREIAA RILKAIRERL QFLNNVGLDY
510 520 530 540 550
LTLARNSGTL SGGESQRIRL ASQIGSGLTG VLYVLDEPSI GLHQRDNARL
560 570 580 590 600
LDTLRHLRDL GNTVIVVEHD EDAILTADYV VDIGPAAGVH GGKVIAQGSP
610 620 630 640 650
QDIMANTNSL TGKYLSGAME VAVPAERRKI SKTKRLRVVG ARGNNLKNVS
660 670 680 690 700
ADIPLGTFTA VTGVSGGGKS TFLIETLFKA ASRRIMGSRE HPAEHDRIEG
710 720 730 740 750
LEFLDKVIDI DQSPIGRTPR SNPATYTGAF TPIRDWFAGL PEAKARGYQP
760 770 780 790 800
GRFSFNVKGG RCEACQGDGV IKIEMHFLPD VYVTCDVCHG KRYNRETLDV
810 820 830 840 850
LFKGKSIADV LDMTVEEGAE FFSAVPAVRD KLETLVKVGL GYIKVGQQAT
860 870 880 890 900
TLSGGEAQRV KLAKELSRRA TGRTLYILDE PTTGLHFHDV AKLLEVLHEL
910 920 930 940 950
VEQGNTVVVI EHNLEVIKTA DWVIDLGPEG GDGGGEIVAV GRPEDIVQEK
960 970
RSYTGQFLKE LLERRPKRSS QAAE
Length:974
Mass (Da):107,423
Last modified:December 20, 2005 - v1
Checksum:i15F7C2BADB7B3127
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11084.1.
L10843 Unassigned DNA. Translation: AAA16817.1.
PIRiI40351.
RefSeqiWP_002964233.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ11084; CAJ11084; BAB1_1128.
GeneIDi3787776.
KEGGibmf:BAB1_1128.
PATRICi17845214. VBIBruMel86222_1177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11084.1.
L10843 Unassigned DNA. Translation: AAA16817.1.
PIRiI40351.
RefSeqiWP_002964233.1. NZ_KN046823.1.

3D structure databases

ProteinModelPortaliQ2YPX5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ11084; CAJ11084; BAB1_1128.
GeneIDi3787776.
KEGGibmf:BAB1_1128.
PATRICi17845214. VBIBruMel86222_1177.

Phylogenomic databases

HOGENOMiHOG000050448.
KOiK03701.
OMAiGAIKGWD.

Miscellaneous databases

PROiQ2YPX5.

Family and domain databases

Gene3Di3.30.1490.20. 2 hits.
3.40.50.300. 4 hits.
HAMAPiMF_00205. UvrA. 1 hit.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013815. ATP_grasp_subdomain_1.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUVRA_BRUA2
AccessioniPrimary (citable) accession number: Q2YPX5
Secondary accession number(s): Q07433, Q57D33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.