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Protein

2-dehydro-3-deoxyphosphooctonate aldolase

Gene

kdsA

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 3-deoxy-8-phosphooctulonate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1178-MONOMER.
BMEL359391:GJOQ-1178-MONOMER.
UniPathwayiUPA00030.
UPA00357; UER00474.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydro-3-deoxyphosphooctonate aldolaseUniRule annotation (EC:2.5.1.55UniRule annotation)
Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthaseUniRule annotation
KDO-8-phosphate synthaseUniRule annotation
Short name:
KDO 8-P synthaseUniRule annotation
Short name:
KDOPSUniRule annotation
Phospho-2-dehydro-3-deoxyoctonate aldolaseUniRule annotation
Gene namesi
Name:kdsAUniRule annotation
Ordered Locus Names:BAB1_1156
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2772772-dehydro-3-deoxyphosphooctonate aldolasePRO_0000304436Add
BLAST

Proteomic databases

PRIDEiQ2YPU9.

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_1156.

Structurei

3D structure databases

ProteinModelPortaliQ2YPU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2877.
HOGENOMiHOG000023021.
KOiK01627.
OMAiESRDHAF.
OrthoDBiEOG680X4R.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00056. KDO8P_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
PANTHERiPTHR21057:SF2. PTHR21057:SF2. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01362. KDO8P_synth. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YPU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTANSTVKV GNVTFSNSAP LALIAGPCQM ETRDHAFEMA GRLKEMTDKL
60 70 80 90 100
GIGLVYKSSF DKANRTSLKA ARGIGLEKAL EVFSDLKKEY GFPVLTDIHT
110 120 130 140 150
EEQCAAVAPV VDVLQIPAFL CRQTDLLIAA ARTGRVVNVK KGQFLAPWDM
160 170 180 190 200
KNVLAKITES GNPNVLATER GVSFGYNTLV SDMRALPIMA GLGAPVIFDA
210 220 230 240 250
THSVQQPGGQ GGSTGGQREF VETLARAAVA VGVAGFFIET HEDPDNAPSD
260 270
GPNMVPIDKM PALLEKLMAF DRIAKAL
Length:277
Mass (Da):29,532
Last modified:February 7, 2006 - v1
Checksum:i1C754D90382F0DD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11112.1.
RefSeqiYP_414547.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ11112; CAJ11112; BAB1_1156.
GeneIDi3787797.
KEGGibmf:BAB1_1156.
PATRICi17845269. VBIBruMel86222_1204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11112.1.
RefSeqiYP_414547.1. NC_007618.1.

3D structure databases

ProteinModelPortaliQ2YPU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359391.BAB1_1156.

Proteomic databases

PRIDEiQ2YPU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ11112; CAJ11112; BAB1_1156.
GeneIDi3787797.
KEGGibmf:BAB1_1156.
PATRICi17845269. VBIBruMel86222_1204.

Phylogenomic databases

eggNOGiCOG2877.
HOGENOMiHOG000023021.
KOiK01627.
OMAiESRDHAF.
OrthoDBiEOG680X4R.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00357; UER00474.
BioCyciBABO359391:GKDV-1178-MONOMER.
BMEL359391:GJOQ-1178-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00056. KDO8P_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
PANTHERiPTHR21057:SF2. PTHR21057:SF2. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01362. KDO8P_synth. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiKDSA_BRUA2
AccessioniPrimary (citable) accession number: Q2YPU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 7, 2006
Last modified: January 7, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.