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Q2YPQ5

- KDSB_BRUA2

UniProt

Q2YPQ5 - KDSB_BRUA2

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Protein
3-deoxy-manno-octulosonate cytidylyltransferase
Gene
kdsB, BAB1_0035
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity.UniRule annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 3-deoxy-manno-octulosonate cytidylyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-UniPathway
  2. keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciBABO359391:GKDV-37-MONOMER.
BMEL359391:GJOQ-37-MONOMER.
UniPathwayiUPA00030.
UPA00358; UER00476.

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferase (EC:2.7.7.38)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name:
CKS
Short name:
CMP-KDO synthase
Gene namesi
Name:kdsB
Ordered Locus Names:BAB1_0035
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2512513-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation
PRO_0000370012Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_0035.

Structurei

3D structure databases

ProteinModelPortaliQ2YPQ5.

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.

Phylogenomic databases

eggNOGiCOG1212.
HOGENOMiHOG000007602.
KOiK00979.
OMAiDDQRIAD.
OrthoDBiEOG6KT2SK.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00057. CMP_KDO_synth.
InterProiIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamiPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR00466. kdsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YPQ5-1 [UniParc]FASTAAdd to Basket

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MLQTMKTLTL IPARLGSTRL PNKPLADICG KPMIVHVADR AAAAKLGRTV    50
IATDSEEIFK VVAAHGHEAI MTRGDHESGS DRIYEALAKL DPSGEIDAVV 100
NVQGDLPTID PDTIRRALLP LEDGPADIAT LGVEITVEEE KTNPNVVKIV 150
GSPLAGNRRL RALYFTRATA PYGEGPLYHH IGLYAYRRSA LERFVKLGPS 200
PLEKREKLEQ LRALEAGMRI DVEIVKTVPL GVDTQADLDR ARTFCSQAGT 250
I 251
Length:251
Mass (Da):27,304
Last modified:February 7, 2006 - v1
Checksum:i945714A32037C6A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ09991.1.
RefSeqiYP_413538.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ09991; CAJ09991; BAB1_0035.
GeneIDi3786850.
KEGGibmf:BAB1_0035.
PATRICi17842891. VBIBruMel86222_0038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ09991.1 .
RefSeqi YP_413538.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YPQ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_0035.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ09991 ; CAJ09991 ; BAB1_0035 .
GeneIDi 3786850.
KEGGi bmf:BAB1_0035.
PATRICi 17842891. VBIBruMel86222_0038.

Phylogenomic databases

eggNOGi COG1212.
HOGENOMi HOG000007602.
KOi K00979.
OMAi DDQRIAD.
OrthoDBi EOG6KT2SK.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00358 ; UER00476 .
BioCyci BABO359391:GKDV-37-MONOMER.
BMEL359391:GJOQ-37-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
HAMAPi MF_00057. CMP_KDO_synth.
InterProi IPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR21485:SF4. PTHR21485:SF4. 1 hit.
Pfami PF02348. CTP_transf_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR00466. kdsB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiKDSB_BRUA2
AccessioniPrimary (citable) accession number: Q2YPQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 7, 2006
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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