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Q2YPQ5

- KDSB_BRUA2

UniProt

Q2YPQ5 - KDSB_BRUA2

Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

    Catalytic activityi

    CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 3-deoxy-manno-octulosonate cytidylyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-UniPathway
    2. keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-37-MONOMER.
    BMEL359391:GJOQ-37-MONOMER.
    UniPathwayiUPA00030.
    UPA00358; UER00476.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)
    Alternative name(s):
    CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
    Short name:
    CKSUniRule annotation
    Short name:
    CMP-KDO synthaseUniRule annotation
    Gene namesi
    Name:kdsBUniRule annotation
    Ordered Locus Names:BAB1_0035
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2512513-deoxy-manno-octulosonate cytidylyltransferasePRO_0000370012Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB1_0035.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YPQ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KdsB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1212.
    HOGENOMiHOG000007602.
    KOiK00979.
    OMAiDDQRIAD.
    OrthoDBiEOG6KT2SK.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    HAMAPiMF_00057. CMP_KDO_synth.
    InterProiIPR003329. Cytidylyl_trans.
    IPR004528. KdsB.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PANTHERiPTHR21485:SF4. PTHR21485:SF4. 1 hit.
    PfamiPF02348. CTP_transf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR00466. kdsB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YPQ5-1 [UniParc]FASTAAdd to Basket

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    MLQTMKTLTL IPARLGSTRL PNKPLADICG KPMIVHVADR AAAAKLGRTV    50
    IATDSEEIFK VVAAHGHEAI MTRGDHESGS DRIYEALAKL DPSGEIDAVV 100
    NVQGDLPTID PDTIRRALLP LEDGPADIAT LGVEITVEEE KTNPNVVKIV 150
    GSPLAGNRRL RALYFTRATA PYGEGPLYHH IGLYAYRRSA LERFVKLGPS 200
    PLEKREKLEQ LRALEAGMRI DVEIVKTVPL GVDTQADLDR ARTFCSQAGT 250
    I 251
    Length:251
    Mass (Da):27,304
    Last modified:February 7, 2006 - v1
    Checksum:i945714A32037C6A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ09991.1.
    RefSeqiYP_413538.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ09991; CAJ09991; BAB1_0035.
    GeneIDi3786850.
    KEGGibmf:BAB1_0035.
    PATRICi17842891. VBIBruMel86222_0038.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ09991.1 .
    RefSeqi YP_413538.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YPQ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_0035.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ09991 ; CAJ09991 ; BAB1_0035 .
    GeneIDi 3786850.
    KEGGi bmf:BAB1_0035.
    PATRICi 17842891. VBIBruMel86222_0038.

    Phylogenomic databases

    eggNOGi COG1212.
    HOGENOMi HOG000007602.
    KOi K00979.
    OMAi DDQRIAD.
    OrthoDBi EOG6KT2SK.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00358 ; UER00476 .
    BioCyci BABO359391:GKDV-37-MONOMER.
    BMEL359391:GJOQ-37-MONOMER.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    HAMAPi MF_00057. CMP_KDO_synth.
    InterProi IPR003329. Cytidylyl_trans.
    IPR004528. KdsB.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    PANTHERi PTHR21485:SF4. PTHR21485:SF4. 1 hit.
    Pfami PF02348. CTP_transf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR00466. kdsB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiKDSB_BRUA2
    AccessioniPrimary (citable) accession number: Q2YPQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3