Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q2YPQ5 (KDSB_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-deoxy-manno-octulosonate cytidylyltransferase

EC=2.7.7.38
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name=CKS
Short name=CMP-KDO synthase
Gene names
Name:kdsB
Ordered Locus Names:BAB1_0035
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP-Rule MF_00057

Catalytic activity

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP-Rule MF_00057

Pathway

Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP-Rule MF_00057

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP-Rule MF_00057

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00057.

Sequence similarities

Belongs to the KdsB family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCytoplasm
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processCMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

keto-3-deoxy-D-manno-octulosonic acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-deoxy-manno-octulosonate cytidylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2512513-deoxy-manno-octulosonate cytidylyltransferase HAMAP-Rule MF_00057
PRO_0000370012

Sequences

Sequence LengthMass (Da)Tools
Q2YPQ5 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 945714A32037C6A7

FASTA25127,304
        10         20         30         40         50         60 
MLQTMKTLTL IPARLGSTRL PNKPLADICG KPMIVHVADR AAAAKLGRTV IATDSEEIFK 

        70         80         90        100        110        120 
VVAAHGHEAI MTRGDHESGS DRIYEALAKL DPSGEIDAVV NVQGDLPTID PDTIRRALLP 

       130        140        150        160        170        180 
LEDGPADIAT LGVEITVEEE KTNPNVVKIV GSPLAGNRRL RALYFTRATA PYGEGPLYHH 

       190        200        210        220        230        240 
IGLYAYRRSA LERFVKLGPS PLEKREKLEQ LRALEAGMRI DVEIVKTVPL GVDTQADLDR 

       250 
ARTFCSQAGT I 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ09991.1.
RefSeqYP_413538.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YPQ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_0035.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ09991; CAJ09991; BAB1_0035.
GeneID3786850.
KEGGbmf:BAB1_0035.
PATRIC17842891. VBIBruMel86222_0038.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1212.
HOGENOMHOG000007602.
KOK00979.
OMAVPYRRHI.
OrthoDBEOG6KT2SK.
ProtClustDBPRK05450.

Enzyme and pathway databases

BioCycBABO359391:GKDV-37-MONOMER.
BMEL359391:GJOQ-37-MONOMER.
UniPathwayUPA00030.
UPA00358; UER00476.

Family and domain databases

HAMAPMF_00057. CMP_KDO_synth.
InterProIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
[Graphical view]
PANTHERPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamPF02348. CTP_transf_3. 1 hit.
[Graphical view]
TIGRFAMsTIGR00466. kdsB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDSB_BRUA2
AccessionPrimary (citable) accession number: Q2YPQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 7, 2006
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names