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Q2YPQ5

- KDSB_BRUA2

UniProt

Q2YPQ5 - KDSB_BRUA2

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Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 3-deoxy-manno-octulosonate cytidylyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-UniPathway
  2. keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciBABO359391:GKDV-37-MONOMER.
BMEL359391:GJOQ-37-MONOMER.
UniPathwayiUPA00030.
UPA00358; UER00476.

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
Short name:
CKSUniRule annotation
Short name:
CMP-KDO synthaseUniRule annotation
Gene namesi
Name:kdsBUniRule annotation
Ordered Locus Names:BAB1_0035
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2512513-deoxy-manno-octulosonate cytidylyltransferasePRO_0000370012Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_0035.

Structurei

3D structure databases

ProteinModelPortaliQ2YPQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1212.
HOGENOMiHOG000007602.
KOiK00979.
OMAiDDQRIAD.
OrthoDBiEOG6KT2SK.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00057. CMP_KDO_synth.
InterProiIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR21485:SF4. PTHR21485:SF4. 1 hit.
PfamiPF02348. CTP_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR00466. kdsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YPQ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQTMKTLTL IPARLGSTRL PNKPLADICG KPMIVHVADR AAAAKLGRTV
60 70 80 90 100
IATDSEEIFK VVAAHGHEAI MTRGDHESGS DRIYEALAKL DPSGEIDAVV
110 120 130 140 150
NVQGDLPTID PDTIRRALLP LEDGPADIAT LGVEITVEEE KTNPNVVKIV
160 170 180 190 200
GSPLAGNRRL RALYFTRATA PYGEGPLYHH IGLYAYRRSA LERFVKLGPS
210 220 230 240 250
PLEKREKLEQ LRALEAGMRI DVEIVKTVPL GVDTQADLDR ARTFCSQAGT

I
Length:251
Mass (Da):27,304
Last modified:February 7, 2006 - v1
Checksum:i945714A32037C6A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ09991.1.
RefSeqiYP_413538.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ09991; CAJ09991; BAB1_0035.
GeneIDi3786850.
KEGGibmf:BAB1_0035.
PATRICi17842891. VBIBruMel86222_0038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ09991.1 .
RefSeqi YP_413538.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YPQ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_0035.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ09991 ; CAJ09991 ; BAB1_0035 .
GeneIDi 3786850.
KEGGi bmf:BAB1_0035.
PATRICi 17842891. VBIBruMel86222_0038.

Phylogenomic databases

eggNOGi COG1212.
HOGENOMi HOG000007602.
KOi K00979.
OMAi DDQRIAD.
OrthoDBi EOG6KT2SK.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00358 ; UER00476 .
BioCyci BABO359391:GKDV-37-MONOMER.
BMEL359391:GJOQ-37-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
HAMAPi MF_00057. CMP_KDO_synth.
InterProi IPR003329. Cytidylyl_trans.
IPR004528. KdsB.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR21485:SF4. PTHR21485:SF4. 1 hit.
Pfami PF02348. CTP_transf_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR00466. kdsB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiKDSB_BRUA2
AccessioniPrimary (citable) accession number: Q2YPQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 7, 2006
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3