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Q2YPN6

- AROA_BRUA2

UniProt

Q2YPN6 - AROA_BRUA2

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Protein
3-phosphoshikimate 1-carboxyvinyltransferase
Gene
aroA, BAB1_0023
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 3-phosphoshikimate 1-carboxyvinyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-KW
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

BioCyciBABO359391:GKDV-24-MONOMER.
BMEL359391:GJOQ-24-MONOMER.
UniPathwayiUPA00053; UER00089.

Names & Taxonomyi

Protein namesi
Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase (EC:2.5.1.19)
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name:
EPSP synthase
Short name:
EPSPS
Gene namesi
Name:aroA
Ordered Locus Names:BAB1_0023
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4504503-phosphoshikimate 1-carboxyvinyltransferaseUniRule annotation
PRO_0000088232Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB1_0023.

Structurei

3D structure databases

ProteinModelPortaliQ2YPN6.
SMRiQ2YPN6. Positions 8-447.

Family & Domainsi

Sequence similaritiesi

Belongs to the EPSP synthase family.

Phylogenomic databases

eggNOGiCOG0128.
HOGENOMiHOG000247371.
KOiK00800.
OMAiKRPMRRI.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00210. EPSP_synth.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF000505. EPSPS. 1 hit.
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01356. aroA. 1 hit.
PROSITEiPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YPN6-1 [UniParc]FASTAAdd to Basket

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MSHSACPKPA TARHSQALTG EIRIPGDKSI SHRSFMFGGL ASGKTRITGL    50
LEGEDVINTG RAMQAMGARI RKEGDVWIIN GVGNGCLLQP EAPLDFGNAG 100
TGARLTMGLV GTYDMKTSFI GDASLSKRPM GRVLNPLREM GVQVEAAEGD 150
RMPLTLIGPR TANPIAYRVP MASAQVKSAV LLAGLNTPGV TTVIEPVMTR 200
DHTEKMLQGF GADLTVETDK DGVRHIRIVG QGKLTGQTID VPGDPSSTAF 250
PLVAALLVEG SEVTIRNVLM NPTRTGLILT LQEMGADIEI IDPRLAGGED 300
VADLRVKASK LKGVVVPPER APSMIDEYPV LAIAASFAEG ETVMDGLDEL 350
RVKESDRLAA VARGLEANGV DCTEGEMSLT VRGRPGGKGL GGGTVATHLD 400
HRIAMSFLVM GLASEKPVTV DDSTMIATSF PEFMGMMAGL GAKIAESGAE 450
Length:450
Mass (Da):47,235
Last modified:December 20, 2005 - v1
Checksum:iC6EEFD498CA72890
GO

Sequence cautioni

The sequence AAK27445.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321H → T in AAK27445. 1 Publication
Sequence conflicti254 – 2541A → P in AAK27445. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF326475 Genomic DNA. Translation: AAK27445.1. Different initiation.
AM040264 Genomic DNA. Translation: CAJ09979.1.
RefSeqiYP_413526.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ09979; CAJ09979; BAB1_0023.
GeneIDi3788620.
KEGGibmf:BAB1_0023.
PATRICi17842863. VBIBruMel86222_0024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF326475 Genomic DNA. Translation: AAK27445.1 . Different initiation.
AM040264 Genomic DNA. Translation: CAJ09979.1 .
RefSeqi YP_413526.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YPN6.
SMRi Q2YPN6. Positions 8-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_0023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ09979 ; CAJ09979 ; BAB1_0023 .
GeneIDi 3788620.
KEGGi bmf:BAB1_0023.
PATRICi 17842863. VBIBruMel86222_0024.

Phylogenomic databases

eggNOGi COG0128.
HOGENOMi HOG000247371.
KOi K00800.
OMAi KRPMRRI.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00089 .
BioCyci BABO359391:GKDV-24-MONOMER.
BMEL359391:GJOQ-24-MONOMER.

Family and domain databases

Gene3Di 3.65.10.10. 2 hits.
HAMAPi MF_00210. EPSP_synth.
InterProi IPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view ]
Pfami PF00275. EPSP_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000505. EPSPS. 1 hit.
SUPFAMi SSF55205. SSF55205. 1 hit.
TIGRFAMsi TIGR01356. aroA. 1 hit.
PROSITEi PS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the aroA gene of Brucella abortus and construction of an aroA mutant."
    Gan T., Essenberg R.C.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiAROA_BRUA2
AccessioniPrimary (citable) accession number: Q2YPN6
Secondary accession number(s): Q57FY8, Q9AGV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 20, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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