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Q2YPN6

- AROA_BRUA2

UniProt

Q2YPN6 - AROA_BRUA2

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Protein

3-phosphoshikimate 1-carboxyvinyltransferase

Gene

aroA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331Shikimate-3-phosphateUniRule annotation
Binding sitei128 – 1281PhosphoenolpyruvateUniRule annotation
Active sitei326 – 3261Proton acceptorUniRule annotation
Binding sitei353 – 3531Shikimate-3-phosphateUniRule annotation
Active sitei354 – 3541Proton donorUniRule annotation
Binding sitei357 – 3571PhosphoenolpyruvateUniRule annotation
Binding sitei402 – 4021PhosphoenolpyruvateUniRule annotation

GO - Molecular functioni

  1. 3-phosphoshikimate 1-carboxyvinyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-KW
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

BioCyciBABO359391:GKDV-24-MONOMER.
BMEL359391:GJOQ-24-MONOMER.
UniPathwayiUPA00053; UER00089.

Names & Taxonomyi

Protein namesi
Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferaseUniRule annotation (EC:2.5.1.19UniRule annotation)
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthaseUniRule annotation
Short name:
EPSP synthaseUniRule annotation
Short name:
EPSPSUniRule annotation
Gene namesi
Name:aroAUniRule annotation
Ordered Locus Names:BAB1_0023
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4504503-phosphoshikimate 1-carboxyvinyltransferasePRO_0000088232Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB1_0023.

Structurei

3D structure databases

ProteinModelPortaliQ2YPN6.
SMRiQ2YPN6. Positions 8-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 292Shikimate-3-phosphate bindingUniRule annotation
Regioni98 – 1014PhosphoenolpyruvateUniRule annotation

Sequence similaritiesi

Belongs to the EPSP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0128.
HOGENOMiHOG000247371.
KOiK00800.
OMAiKRPMRRI.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00210. EPSP_synth.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF000505. EPSPS. 1 hit.
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01356. aroA. 1 hit.
PROSITEiPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YPN6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHSACPKPA TARHSQALTG EIRIPGDKSI SHRSFMFGGL ASGKTRITGL
60 70 80 90 100
LEGEDVINTG RAMQAMGARI RKEGDVWIIN GVGNGCLLQP EAPLDFGNAG
110 120 130 140 150
TGARLTMGLV GTYDMKTSFI GDASLSKRPM GRVLNPLREM GVQVEAAEGD
160 170 180 190 200
RMPLTLIGPR TANPIAYRVP MASAQVKSAV LLAGLNTPGV TTVIEPVMTR
210 220 230 240 250
DHTEKMLQGF GADLTVETDK DGVRHIRIVG QGKLTGQTID VPGDPSSTAF
260 270 280 290 300
PLVAALLVEG SEVTIRNVLM NPTRTGLILT LQEMGADIEI IDPRLAGGED
310 320 330 340 350
VADLRVKASK LKGVVVPPER APSMIDEYPV LAIAASFAEG ETVMDGLDEL
360 370 380 390 400
RVKESDRLAA VARGLEANGV DCTEGEMSLT VRGRPGGKGL GGGTVATHLD
410 420 430 440 450
HRIAMSFLVM GLASEKPVTV DDSTMIATSF PEFMGMMAGL GAKIAESGAE
Length:450
Mass (Da):47,235
Last modified:December 20, 2005 - v1
Checksum:iC6EEFD498CA72890
GO

Sequence cautioni

The sequence AAK27445.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortenedCurated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321H → T in AAK27445. 1 PublicationCurated
Sequence conflicti254 – 2541A → P in AAK27445. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326475 Genomic DNA. Translation: AAK27445.1. Different initiation.
AM040264 Genomic DNA. Translation: CAJ09979.1.
RefSeqiYP_413526.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ09979; CAJ09979; BAB1_0023.
GeneIDi3788620.
KEGGibmf:BAB1_0023.
PATRICi17842863. VBIBruMel86222_0024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF326475 Genomic DNA. Translation: AAK27445.1 . Different initiation.
AM040264 Genomic DNA. Translation: CAJ09979.1 .
RefSeqi YP_413526.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YPN6.
SMRi Q2YPN6. Positions 8-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_0023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ09979 ; CAJ09979 ; BAB1_0023 .
GeneIDi 3788620.
KEGGi bmf:BAB1_0023.
PATRICi 17842863. VBIBruMel86222_0024.

Phylogenomic databases

eggNOGi COG0128.
HOGENOMi HOG000247371.
KOi K00800.
OMAi KRPMRRI.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00089 .
BioCyci BABO359391:GKDV-24-MONOMER.
BMEL359391:GJOQ-24-MONOMER.

Family and domain databases

Gene3Di 3.65.10.10. 2 hits.
HAMAPi MF_00210. EPSP_synth.
InterProi IPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view ]
Pfami PF00275. EPSP_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000505. EPSPS. 1 hit.
SUPFAMi SSF55205. SSF55205. 1 hit.
TIGRFAMsi TIGR01356. aroA. 1 hit.
PROSITEi PS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the aroA gene of Brucella abortus and construction of an aroA mutant."
    Gan T., Essenberg R.C.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiAROA_BRUA2
AccessioniPrimary (citable) accession number: Q2YPN6
Secondary accession number(s): Q57FY8, Q9AGV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 20, 2005
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3