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Q2YPN6

- AROA_BRUA2

UniProt

Q2YPN6 - AROA_BRUA2

Protein

3-phosphoshikimate 1-carboxyvinyltransferase

Gene

aroA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 3-phosphoshikimate 1-carboxyvinyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-KW
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-24-MONOMER.
    BMEL359391:GJOQ-24-MONOMER.
    UniPathwayiUPA00053; UER00089.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferaseUniRule annotation (EC:2.5.1.19UniRule annotation)
    Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthaseUniRule annotation
    Short name:
    EPSP synthaseUniRule annotation
    Short name:
    EPSPSUniRule annotation
    Gene namesi
    Name:aroAUniRule annotation
    Ordered Locus Names:BAB1_0023
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4504503-phosphoshikimate 1-carboxyvinyltransferasePRO_0000088232Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_0023.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YPN6.
    SMRiQ2YPN6. Positions 8-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EPSP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0128.
    HOGENOMiHOG000247371.
    KOiK00800.
    OMAiKRPMRRI.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.65.10.10. 2 hits.
    HAMAPiMF_00210. EPSP_synth.
    InterProiIPR001986. Enolpyruvate_Tfrase_dom.
    IPR006264. EPSP_synthase.
    IPR023193. EPSP_synthase_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view]
    PfamiPF00275. EPSP_synthase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000505. EPSPS. 1 hit.
    SUPFAMiSSF55205. SSF55205. 1 hit.
    TIGRFAMsiTIGR01356. aroA. 1 hit.
    PROSITEiPS00104. EPSP_SYNTHASE_1. 1 hit.
    PS00885. EPSP_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YPN6-1 [UniParc]FASTAAdd to Basket

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    MSHSACPKPA TARHSQALTG EIRIPGDKSI SHRSFMFGGL ASGKTRITGL    50
    LEGEDVINTG RAMQAMGARI RKEGDVWIIN GVGNGCLLQP EAPLDFGNAG 100
    TGARLTMGLV GTYDMKTSFI GDASLSKRPM GRVLNPLREM GVQVEAAEGD 150
    RMPLTLIGPR TANPIAYRVP MASAQVKSAV LLAGLNTPGV TTVIEPVMTR 200
    DHTEKMLQGF GADLTVETDK DGVRHIRIVG QGKLTGQTID VPGDPSSTAF 250
    PLVAALLVEG SEVTIRNVLM NPTRTGLILT LQEMGADIEI IDPRLAGGED 300
    VADLRVKASK LKGVVVPPER APSMIDEYPV LAIAASFAEG ETVMDGLDEL 350
    RVKESDRLAA VARGLEANGV DCTEGEMSLT VRGRPGGKGL GGGTVATHLD 400
    HRIAMSFLVM GLASEKPVTV DDSTMIATSF PEFMGMMAGL GAKIAESGAE 450
    Length:450
    Mass (Da):47,235
    Last modified:December 20, 2005 - v1
    Checksum:iC6EEFD498CA72890
    GO

    Sequence cautioni

    The sequence AAK27445.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321H → T in AAK27445. 1 PublicationCurated
    Sequence conflicti254 – 2541A → P in AAK27445. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF326475 Genomic DNA. Translation: AAK27445.1. Different initiation.
    AM040264 Genomic DNA. Translation: CAJ09979.1.
    RefSeqiYP_413526.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ09979; CAJ09979; BAB1_0023.
    GeneIDi3788620.
    KEGGibmf:BAB1_0023.
    PATRICi17842863. VBIBruMel86222_0024.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF326475 Genomic DNA. Translation: AAK27445.1 . Different initiation.
    AM040264 Genomic DNA. Translation: CAJ09979.1 .
    RefSeqi YP_413526.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YPN6.
    SMRi Q2YPN6. Positions 8-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_0023.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ09979 ; CAJ09979 ; BAB1_0023 .
    GeneIDi 3788620.
    KEGGi bmf:BAB1_0023.
    PATRICi 17842863. VBIBruMel86222_0024.

    Phylogenomic databases

    eggNOGi COG0128.
    HOGENOMi HOG000247371.
    KOi K00800.
    OMAi KRPMRRI.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00089 .
    BioCyci BABO359391:GKDV-24-MONOMER.
    BMEL359391:GJOQ-24-MONOMER.

    Family and domain databases

    Gene3Di 3.65.10.10. 2 hits.
    HAMAPi MF_00210. EPSP_synth.
    InterProi IPR001986. Enolpyruvate_Tfrase_dom.
    IPR006264. EPSP_synthase.
    IPR023193. EPSP_synthase_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view ]
    Pfami PF00275. EPSP_synthase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000505. EPSPS. 1 hit.
    SUPFAMi SSF55205. SSF55205. 1 hit.
    TIGRFAMsi TIGR01356. aroA. 1 hit.
    PROSITEi PS00104. EPSP_SYNTHASE_1. 1 hit.
    PS00885. EPSP_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the aroA gene of Brucella abortus and construction of an aroA mutant."
      Gan T., Essenberg R.C.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiAROA_BRUA2
    AccessioniPrimary (citable) accession number: Q2YPN6
    Secondary accession number(s): Q57FY8, Q9AGV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3