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Q2YPN6 (AROA_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase

EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:BAB1_0023
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP-Rule MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP-Rule MF_00210

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00210

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Sequence caution

The sequence AAK27445.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

chorismate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4504503-phosphoshikimate 1-carboxyvinyltransferase HAMAP-Rule MF_00210
PRO_0000088232

Experimental info

Sequence conflict321H → T in AAK27445. Ref.1
Sequence conflict2541A → P in AAK27445. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q2YPN6 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: C6EEFD498CA72890

FASTA45047,235
        10         20         30         40         50         60 
MSHSACPKPA TARHSQALTG EIRIPGDKSI SHRSFMFGGL ASGKTRITGL LEGEDVINTG 

        70         80         90        100        110        120 
RAMQAMGARI RKEGDVWIIN GVGNGCLLQP EAPLDFGNAG TGARLTMGLV GTYDMKTSFI 

       130        140        150        160        170        180 
GDASLSKRPM GRVLNPLREM GVQVEAAEGD RMPLTLIGPR TANPIAYRVP MASAQVKSAV 

       190        200        210        220        230        240 
LLAGLNTPGV TTVIEPVMTR DHTEKMLQGF GADLTVETDK DGVRHIRIVG QGKLTGQTID 

       250        260        270        280        290        300 
VPGDPSSTAF PLVAALLVEG SEVTIRNVLM NPTRTGLILT LQEMGADIEI IDPRLAGGED 

       310        320        330        340        350        360 
VADLRVKASK LKGVVVPPER APSMIDEYPV LAIAASFAEG ETVMDGLDEL RVKESDRLAA 

       370        380        390        400        410        420 
VARGLEANGV DCTEGEMSLT VRGRPGGKGL GGGTVATHLD HRIAMSFLVM GLASEKPVTV 

       430        440        450 
DDSTMIATSF PEFMGMMAGL GAKIAESGAE 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the aroA gene of Brucella abortus and construction of an aroA mutant."
Gan T., Essenberg R.C.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF326475 Genomic DNA. Translation: AAK27445.1. Different initiation.
AM040264 Genomic DNA. Translation: CAJ09979.1.
RefSeqYP_413526.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YPN6.
SMRQ2YPN6. Positions 8-447.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_0023.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ09979; CAJ09979; BAB1_0023.
GeneID3788620.
KEGGbmf:BAB1_0023.
PATRIC17842863. VBIBruMel86222_0024.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0128.
HOGENOMHOG000247371.
KOK00800.
OMAKRPMRRI.
OrthoDBEOG6Z6FZ4.

Enzyme and pathway databases

BioCycBABO359391:GKDV-24-MONOMER.
BMEL359391:GJOQ-24-MONOMER.
UniPathwayUPA00053; UER00089.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00210. EPSP_synth.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01356. aroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_BRUA2
AccessionPrimary (citable) accession number: Q2YPN6
Secondary accession number(s): Q57FY8, Q9AGV2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: December 20, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names