Q2YPJ2 (MSCL_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel

Gene names

Name:	mscL
Ordered Locus Names:	BAB1_0348

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115
Subunit structure	Homopentamer By similarity. HAMAP MF_00115
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ionic channel
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 138	138	Large-conductance mechanosensitive channel HAMAP MF_00115		PRO_0000237985
Regions
	Transmembrane	15 – 35	21	Helical; Potential
	Transmembrane	38 – 58	21	Helical; Potential
	Transmembrane	80 – 100	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2YPJ2 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 64ADC7B8F6239A96	FASTA	138	14,899
	10 20 30 40 50 60 MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI DFSNMFIQLA 70 80 90 100 110 120 GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV KLMNRLKKRE EAKPAPAAPS 130 EEVLLTEIRD ILAKQQKA

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040264 Genomic DNA. Translation: CAJ10304.1.
RefSeq	YP_413816.1. NC_007618.1.
3D structure databases
ProteinModelPortal	Q2YPJ2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YPJ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3788805.
GenomeReviews	Gene locus BAB1_0348 in contig AM040264_GR.
KEGG	bmf:BAB1_0348.
PATRIC	17843564. VBIBruMel86222_0367.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1970.
HOGENOM	HBG727604.
OMA	IKATRCP.
ProtClustDB	PRK13952.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0348-MONOMER.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
PROSITE	PS01327. MSCL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSCL_BRUA2

Accession

Primary (citable) accession number: Q2YPJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	December 20, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program