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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciBABO359391:GKDV-355-MONOMER.
BMEL359391:GJOQ-355-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channelUniRule annotation
Gene namesi
Name:mscLUniRule annotation
Ordered Locus Names:BAB1_0348
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalUniRule annotationAdd
BLAST
Transmembranei38 – 5821HelicalUniRule annotationAdd
BLAST
Transmembranei80 – 10021HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Large-conductance mechanosensitive channelPRO_0000237985Add
BLAST

Proteomic databases

PRIDEiQ2YPJ2.

Interactioni

Subunit structurei

Homopentamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2YPJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1970.
HOGENOMiHOG000226782.
KOiK03282.
OMAiYGSFIQT.
OrthoDBiEOG696C3G.

Family and domain databases

HAMAPiMF_00115. MscL.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YPJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI
60 70 80 90 100
DFSNMFIQLA GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV
110 120 130
KLMNRLKKRE EAKPAPAAPS EEVLLTEIRD ILAKQQKA
Length:138
Mass (Da):14,899
Last modified:December 20, 2005 - v1
Checksum:i64ADC7B8F6239A96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ10304.1.
RefSeqiWP_002963483.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ10304; CAJ10304; BAB1_0348.
GeneIDi3788805.
KEGGibmf:BAB1_0348.
PATRICi17843564. VBIBruMel86222_0367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ10304.1.
RefSeqiWP_002963483.1. NZ_KN046823.1.

3D structure databases

ProteinModelPortaliQ2YPJ2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ2YPJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ10304; CAJ10304; BAB1_0348.
GeneIDi3788805.
KEGGibmf:BAB1_0348.
PATRICi17843564. VBIBruMel86222_0367.

Phylogenomic databases

eggNOGiCOG1970.
HOGENOMiHOG000226782.
KOiK03282.
OMAiYGSFIQT.
OrthoDBiEOG696C3G.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-355-MONOMER.
BMEL359391:GJOQ-355-MONOMER.

Family and domain databases

HAMAPiMF_00115. MscL.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiMSCL_BRUA2
AccessioniPrimary (citable) accession number: Q2YPJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 20, 2005
Last modified: July 22, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.