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Q2YPJ2 (MSCL_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Large-conductance mechanosensitive channel
Gene names
Name:mscL
Ordered Locus Names:BAB1_0348
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP-Rule MF_00115

Subunit structure

Homopentamer By similarity. HAMAP-Rule MF_00115

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00115.

Sequence similarities

Belongs to the MscL family.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionIon channel
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionion channel activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 138138Large-conductance mechanosensitive channel HAMAP-Rule MF_00115
PRO_0000237985

Regions

Transmembrane15 – 3521Helical; Potential
Transmembrane38 – 5821Helical; Potential
Transmembrane80 – 10021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q2YPJ2 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 64ADC7B8F6239A96

FASTA13814,899
        10         20         30         40         50         60 
MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI DFSNMFIQLA 

        70         80         90        100        110        120 
GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV KLMNRLKKRE EAKPAPAAPS 

       130 
EEVLLTEIRD ILAKQQKA 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ10304.1.
RefSeqYP_413816.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YPJ2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_0348.

Proteomic databases

PRIDEQ2YPJ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ10304; CAJ10304; BAB1_0348.
GeneID3788805.
KEGGbmf:BAB1_0348.
PATRIC17843564. VBIBruMel86222_0367.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1970.
HOGENOMHOG000226782.
KOK03282.
OMASDIIMPP.
OrthoDBEOG696C3G.
ProtClustDBPRK13952.

Enzyme and pathway databases

BioCycBABO359391:GKDV-355-MONOMER.
BMEL359391:GJOQ-355-MONOMER.

Family and domain databases

HAMAPMF_00115. MscL.
InterProIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamPF01741. MscL. 1 hit.
[Graphical view]
PRINTSPR01264. MECHCHANNEL.
SUPFAMSSF81330. SSF81330. 1 hit.
TIGRFAMsTIGR00220. mscL. 1 hit.
PROSITEPS01327. MSCL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMSCL_BRUA2
AccessionPrimary (citable) accession number: Q2YPJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 20, 2005
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names