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Reviewed, UniProtKB/Swiss-Prot Q2YPJ2 (MSCL_BRUA2)

Last modified November 24, 2009. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Large-conductance mechanosensitive channel
Gene names
Name: mscL
Ordered Locus Names: BAB1_0348
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity.

Subunit structure

Homopentamer By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the mscL family.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
   Molecular functionIonic channel
   Technical termComplete proteome
Gene Ontology (GO)
   Biological procession transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: HAMAP

   Molecular functionion channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 138138Large-conductance mechanosensitive channel HAMAP MF_00115
PRO_0000237985

Regions

Transmembrane15 – 3521 Potential
Transmembrane38 – 5821 Potential
Transmembrane80 – 10021 Potential

Sequences

Sequence LengthMass (Da)Tools
Q2YPJ2-1 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 64ADC7B8F6239A96

FASTA13814,899
        10         20         30         40         50         60 
MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI DFSNMFIQLA 

        70         80         90        100        110        120 
GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV KLMNRLKKRE EAKPAPAAPS 

       130 
EEVLLTEIRD ILAKQQKA 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

AM040264 Genomic DNA. Translation: CAJ10304.1.
RefSeqYP_413816.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ2YPJ2.

Genome annotation databases

GeneID3788805.
GenomeReviewsGene locus BAB1_0348 in contig AM040264_GR.
KEGGbmf:BAB1_0348.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ2YPJ2.
OMAMIKEFKE

Enzyme and pathway databases

BioCycBMEL359391:BAB1_0348-MON.

Family and domain databases

HAMAPMF_00115.
[Tree]
InterProIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamPF01741. MscL. 1 hit.
[Graphical view]
PRINTSPR01264. MECHCHANNEL.
TIGRFAMsTIGR00220. mscL. 1 hit.
PROSITEPS01327. MSCL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMSCL_BRUA2
AccessionPrimary (citable) accession number: Q2YPJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 20, 2005
Last modified: November 24, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents