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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channelUniRule annotation
Gene namesi
Name:mscLUniRule annotation
Ordered Locus Names:BAB1_0348
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002379851 – 138Large-conductance mechanosensitive channelAdd BLAST138

Proteomic databases

PRIDEiQ2YPJ2

Interactioni

Subunit structurei

Homopentamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2YPJ2
SMRiQ2YPJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000226782
KOiK03282
OMAiYGSFIQT

Family and domain databases

Gene3Di1.10.1200.120, 1 hit
HAMAPiMF_00115 MscL, 1 hit
InterProiView protein in InterPro
IPR036019 Gated_MS_channel
IPR019823 Mechanosensitive_channel_CS
IPR001185 MS_channel
IPR037673 MSC/AndL
PANTHERiPTHR30266 PTHR30266, 1 hit
PfamiView protein in Pfam
PF01741 MscL, 1 hit
PRINTSiPR01264 MECHCHANNEL
SUPFAMiSSF81330 SSF81330, 1 hit
TIGRFAMsiTIGR00220 mscL, 1 hit
PROSITEiView protein in PROSITE
PS01327 MSCL, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YPJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI
60 70 80 90 100
DFSNMFIQLA GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV
110 120 130
KLMNRLKKRE EAKPAPAAPS EEVLLTEIRD ILAKQQKA
Length:138
Mass (Da):14,899
Last modified:December 20, 2005 - v1
Checksum:i64ADC7B8F6239A96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA Translation: CAJ10304.1
RefSeqiWP_002963483.1, NZ_KN046823.1

Genome annotation databases

EnsemblBacteriaiCAJ10304; CAJ10304; BAB1_0348
GeneIDi29594451
KEGGibmf:BAB1_0348
PATRICifig|359391.11.peg.2393

Similar proteinsi

Entry informationi

Entry nameiMSCL_BRUA2
AccessioniPrimary (citable) accession number: Q2YPJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 20, 2005
Last modified: April 25, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health