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Q2YPJ2

- MSCL_BRUA2

UniProt

Q2YPJ2 - MSCL_BRUA2

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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.UniRule annotation

GO - Molecular functioni

  1. ion channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciBABO359391:GKDV-355-MONOMER.
BMEL359391:GJOQ-355-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channelUniRule annotation
Gene namesi
Name:mscLUniRule annotation
Ordered Locus Names:BAB1_0348
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Large-conductance mechanosensitive channelPRO_0000237985Add
BLAST

Proteomic databases

PRIDEiQ2YPJ2.

Interactioni

Subunit structurei

Homopentamer.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB1_0348.

Structurei

3D structure databases

ProteinModelPortaliQ2YPJ2.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalUniRule annotationAdd
BLAST
Transmembranei38 – 5821HelicalUniRule annotationAdd
BLAST
Transmembranei80 – 10021HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1970.
HOGENOMiHOG000226782.
KOiK03282.
OMAiFIQTVFD.
OrthoDBiEOG696C3G.

Family and domain databases

HAMAPiMF_00115. MscL.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YPJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI
60 70 80 90 100
DFSNMFIQLA GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV
110 120 130
KLMNRLKKRE EAKPAPAAPS EEVLLTEIRD ILAKQQKA
Length:138
Mass (Da):14,899
Last modified:December 20, 2005 - v1
Checksum:i64ADC7B8F6239A96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ10304.1.
RefSeqiYP_413816.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ10304; CAJ10304; BAB1_0348.
GeneIDi3788805.
KEGGibmf:BAB1_0348.
PATRICi17843564. VBIBruMel86222_0367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ10304.1 .
RefSeqi YP_413816.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YPJ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_0348.

Proteomic databases

PRIDEi Q2YPJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ10304 ; CAJ10304 ; BAB1_0348 .
GeneIDi 3788805.
KEGGi bmf:BAB1_0348.
PATRICi 17843564. VBIBruMel86222_0367.

Phylogenomic databases

eggNOGi COG1970.
HOGENOMi HOG000226782.
KOi K03282.
OMAi FIQTVFD.
OrthoDBi EOG696C3G.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-355-MONOMER.
BMEL359391:GJOQ-355-MONOMER.

Family and domain databases

HAMAPi MF_00115. MscL.
InterProi IPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view ]
Pfami PF01741. MscL. 1 hit.
[Graphical view ]
PRINTSi PR01264. MECHCHANNEL.
SUPFAMi SSF81330. SSF81330. 1 hit.
TIGRFAMsi TIGR00220. mscL. 1 hit.
PROSITEi PS01327. MSCL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiMSCL_BRUA2
AccessioniPrimary (citable) accession number: Q2YPJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3