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Q2YPJ2

- MSCL_BRUA2

UniProt

Q2YPJ2 - MSCL_BRUA2

Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.UniRule annotation

    GO - Molecular functioni

    1. ion channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-355-MONOMER.
    BMEL359391:GJOQ-355-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Large-conductance mechanosensitive channelUniRule annotation
    Gene namesi
    Name:mscLUniRule annotation
    Ordered Locus Names:BAB1_0348
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 138138Large-conductance mechanosensitive channelPRO_0000237985Add
    BLAST

    Proteomic databases

    PRIDEiQ2YPJ2.

    Interactioni

    Subunit structurei

    Homopentamer.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_0348.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YPJ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalUniRule annotationAdd
    BLAST
    Transmembranei38 – 5821HelicalUniRule annotationAdd
    BLAST
    Transmembranei80 – 10021HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MscL family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1970.
    HOGENOMiHOG000226782.
    KOiK03282.
    OMAiFIQTVFD.
    OrthoDBiEOG696C3G.

    Family and domain databases

    HAMAPiMF_00115. MscL.
    InterProiIPR019823. Mechanosensitive_channel_CS.
    IPR001185. MS_channel.
    [Graphical view]
    PfamiPF01741. MscL. 1 hit.
    [Graphical view]
    PRINTSiPR01264. MECHCHANNEL.
    SUPFAMiSSF81330. SSF81330. 1 hit.
    TIGRFAMsiTIGR00220. mscL. 1 hit.
    PROSITEiPS01327. MSCL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YPJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI    50
    DFSNMFIQLA GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV 100
    KLMNRLKKRE EAKPAPAAPS EEVLLTEIRD ILAKQQKA 138
    Length:138
    Mass (Da):14,899
    Last modified:December 20, 2005 - v1
    Checksum:i64ADC7B8F6239A96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10304.1.
    RefSeqiYP_413816.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ10304; CAJ10304; BAB1_0348.
    GeneIDi3788805.
    KEGGibmf:BAB1_0348.
    PATRICi17843564. VBIBruMel86222_0367.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10304.1 .
    RefSeqi YP_413816.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YPJ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_0348.

    Proteomic databases

    PRIDEi Q2YPJ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ10304 ; CAJ10304 ; BAB1_0348 .
    GeneIDi 3788805.
    KEGGi bmf:BAB1_0348.
    PATRICi 17843564. VBIBruMel86222_0367.

    Phylogenomic databases

    eggNOGi COG1970.
    HOGENOMi HOG000226782.
    KOi K03282.
    OMAi FIQTVFD.
    OrthoDBi EOG696C3G.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-355-MONOMER.
    BMEL359391:GJOQ-355-MONOMER.

    Family and domain databases

    HAMAPi MF_00115. MscL.
    InterProi IPR019823. Mechanosensitive_channel_CS.
    IPR001185. MS_channel.
    [Graphical view ]
    Pfami PF01741. MscL. 1 hit.
    [Graphical view ]
    PRINTSi PR01264. MECHCHANNEL.
    SUPFAMi SSF81330. SSF81330. 1 hit.
    TIGRFAMsi TIGR00220. mscL. 1 hit.
    PROSITEi PS01327. MSCL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiMSCL_BRUA2
    AccessioniPrimary (citable) accession number: Q2YPJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3