Reviewed, UniProtKB/Swiss-Prot Q2YPH2 (OTC_BRUA2)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	BAB1_0332

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_1000065076
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	264 – 267	4	Ornithine binding By similarity
Sites
	Binding site	108	1	Carbamoyl phosphate By similarity
	Binding site	135	1	Carbamoyl phosphate By similarity
	Site	32	1	Important for structural integrity By similarity
	Site	148	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YPH2-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 60DBB4EC456B939C	FASTA	312	34,239
	10 20 30 40 50 60 MANDNGIKHF IDLSTVPATE LRAILEDAKA RKARLKAGEV ERPYAGKVLA MIFEKLSTRT 70 80 90 100 110 120 RVSFDVGMRQ LGGETIMLTG SEMQLGRSET IADTAKVLSR YVDAIMIRTT AHERMLELAE 130 140 150 160 170 180 YATVPVINAL TDDTHPCQIM ADVLTYEEHR GPIKGKTFAW MGDGNNVLHS LVEAAARFDF 190 200 210 220 230 240 NVNIATPKGS EPKSQYIDWA RANGAGIMST TDPEKAASGA DCIVTDTWVS MGQEDHARGH 250 260 270 280 290 300 NVFIPYQVNA NLMAKADPKA LFMHCLPAHR GEEVTDEVID GPQSVVFDEA ENRLHAQKAI 310 LAWCLQDRGL GA

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM040264 Genomic DNA. Translation: CAJ10288.1.
RefSeq	YP_413800.1.
3D structure databases
HSSP	HSSP built from PDB template 1VLV based on UniProtKB P96108.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YPH2.
Genome annotation databases
GeneID	3787107.
GenomeReviews	Gene locus BAB1_0332 in contig AM040264_GR.
KEGG	bmf:BAB1_0332.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2YPH2.
OMA	CVVTDTW
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0332-MON.
Family and domain databases
HAMAP	MF_01109. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_BRUA2

Accession

Primary (citable) accession number: Q2YPH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 7, 2006
Last modified:	November 24, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)