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Q2YPD8

- URED1_BRUA2

UniProt

Q2YPD8 - URED1_BRUA2

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Protein
Urease accessory protein UreD 1
Gene
ureD1, ureD-1, BAB1_0297
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter By similarity.1 Publication
Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral.1 Publication

GO - Molecular functioni

  1. nickel cation binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. nitrogen compound metabolic process Source: InterPro
  2. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Nickel insertion, Virulence

Enzyme and pathway databases

BioCyciBABO359391:GKDV-303-MONOMER.
BMEL359391:GJOQ-303-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease accessory protein UreD 1
Gene namesi
Name:ureD1
Synonyms:ureD-1
Ordered Locus Names:BAB1_0297
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Urease accessory protein UreD 1UniRule annotation
PRO_0000340419Add
BLAST

Interactioni

Subunit structurei

UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel By similarity.

Protein-protein interaction databases

STRINGi359391.BAB1_0297.

Family & Domainsi

Sequence similaritiesi

Belongs to the UreD family.

Phylogenomic databases

eggNOGiCOG0829.
HOGENOMiHOG000263489.
KOiK03190.
OMAiILFDRAR.
OrthoDBiEOG6W9X5J.

Family and domain databases

HAMAPiMF_01384. UreD.
InterProiIPR002669. UreD.
[Graphical view]
PfamiPF01774. UreD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YPD8-1 [UniParc]FASTAAdd to Basket

« Hide

MLIINDNNLS GLSLQRVNGT GELSVQFKDG RSRISRLYQE GAAKIRMPQA    50
VTGPLEAILI NTSGGLTGGD RLKWDVALDD GASAVITTQA CERIYRSGGG 100
EARIATRLKA AKGTRLAWLP QETILFNRSI LSRRLDVELE EGAQMLVVEA 150
TVFGRLAMGE RVVAARFADR WRVRLGGRVI HAEEFRLGPD VGAELQAPAV 200
AGGACAMATV LMVCEQAGRY LETARAIIGE EGGCSLWRVG KASKLVVRLY 250
APDSYALRRR LCPLVALLNG KAGLPKVWTI 280
Length:280
Mass (Da):30,256
Last modified:February 7, 2006 - v1
Checksum:i3FE5CA77016C952C
GO

Sequence cautioni

The sequence AAK51066.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF361941 Genomic DNA. Translation: AAK51066.1. Different initiation.
AM040264 Genomic DNA. Translation: CAJ10253.1.
RefSeqiYP_413768.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ10253; CAJ10253; BAB1_0297.
GeneIDi3789049.
KEGGibmf:BAB1_0297.
PATRICi17843460. VBIBruMel86222_0316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF361941 Genomic DNA. Translation: AAK51066.1 . Different initiation.
AM040264 Genomic DNA. Translation: CAJ10253.1 .
RefSeqi YP_413768.1. NC_007618.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_0297.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ10253 ; CAJ10253 ; BAB1_0297 .
GeneIDi 3789049.
KEGGi bmf:BAB1_0297.
PATRICi 17843460. VBIBruMel86222_0316.

Phylogenomic databases

eggNOGi COG0829.
HOGENOMi HOG000263489.
KOi K03190.
OMAi ILFDRAR.
OrthoDBi EOG6W9X5J.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-303-MONOMER.
BMEL359391:GJOQ-303-MONOMER.

Family and domain databases

HAMAPi MF_01384. UreD.
InterProi IPR002669. UreD.
[Graphical view ]
Pfami PF01774. UreD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium."
    Sangari F.J., Seoane A., Rodriguez M.C., Aguero J., Garcia Lobo J.M.
    Infect. Immun. 75:774-780(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ROLE IN VIRULENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiURED1_BRUA2
AccessioniPrimary (citable) accession number: Q2YPD8
Secondary accession number(s): Q93T84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi