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Q2YPD8

- URED1_BRUA2

UniProt

Q2YPD8 - URED1_BRUA2

Protein

Urease accessory protein UreD 1

Gene

ureD1

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.UniRule annotation
    Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral.1 Publication

    GO - Molecular functioni

    1. nickel cation binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. nitrogen compound metabolic process Source: InterPro
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Nickel insertion, Virulence

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-303-MONOMER.
    BMEL359391:GJOQ-303-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urease accessory protein UreD 1UniRule annotation
    Gene namesi
    Name:ureD1UniRule annotation
    Synonyms:ureD-1
    Ordered Locus Names:BAB1_0297
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 280280Urease accessory protein UreD 1PRO_0000340419Add
    BLAST

    Interactioni

    Subunit structurei

    UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_0297.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UreD family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0829.
    HOGENOMiHOG000263489.
    KOiK03190.
    OMAiILFDRAR.
    OrthoDBiEOG6W9X5J.

    Family and domain databases

    HAMAPiMF_01384. UreD.
    InterProiIPR002669. UreD.
    [Graphical view]
    PfamiPF01774. UreD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YPD8-1 [UniParc]FASTAAdd to Basket

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    MLIINDNNLS GLSLQRVNGT GELSVQFKDG RSRISRLYQE GAAKIRMPQA    50
    VTGPLEAILI NTSGGLTGGD RLKWDVALDD GASAVITTQA CERIYRSGGG 100
    EARIATRLKA AKGTRLAWLP QETILFNRSI LSRRLDVELE EGAQMLVVEA 150
    TVFGRLAMGE RVVAARFADR WRVRLGGRVI HAEEFRLGPD VGAELQAPAV 200
    AGGACAMATV LMVCEQAGRY LETARAIIGE EGGCSLWRVG KASKLVVRLY 250
    APDSYALRRR LCPLVALLNG KAGLPKVWTI 280
    Length:280
    Mass (Da):30,256
    Last modified:February 7, 2006 - v1
    Checksum:i3FE5CA77016C952C
    GO

    Sequence cautioni

    The sequence AAK51066.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361941 Genomic DNA. Translation: AAK51066.1. Different initiation.
    AM040264 Genomic DNA. Translation: CAJ10253.1.
    RefSeqiYP_413768.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ10253; CAJ10253; BAB1_0297.
    GeneIDi3789049.
    KEGGibmf:BAB1_0297.
    PATRICi17843460. VBIBruMel86222_0316.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361941 Genomic DNA. Translation: AAK51066.1 . Different initiation.
    AM040264 Genomic DNA. Translation: CAJ10253.1 .
    RefSeqi YP_413768.1. NC_007618.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_0297.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ10253 ; CAJ10253 ; BAB1_0297 .
    GeneIDi 3789049.
    KEGGi bmf:BAB1_0297.
    PATRICi 17843460. VBIBruMel86222_0316.

    Phylogenomic databases

    eggNOGi COG0829.
    HOGENOMi HOG000263489.
    KOi K03190.
    OMAi ILFDRAR.
    OrthoDBi EOG6W9X5J.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-303-MONOMER.
    BMEL359391:GJOQ-303-MONOMER.

    Family and domain databases

    HAMAPi MF_01384. UreD.
    InterProi IPR002669. UreD.
    [Graphical view ]
    Pfami PF01774. UreD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium."
      Sangari F.J., Seoane A., Rodriguez M.C., Aguero J., Garcia Lobo J.M.
      Infect. Immun. 75:774-780(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ROLE IN VIRULENCE.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiURED1_BRUA2
    AccessioniPrimary (citable) accession number: Q2YPD8
    Secondary accession number(s): Q93T84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3