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Protein

Urease accessory protein UreD 1

Gene

ureD1

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.UniRule annotation
Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Nickel insertion, Virulence

Enzyme and pathway databases

BioCyciBABO359391:GKDV-303-MONOMER.
BMEL359391:GJOQ-303-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease accessory protein UreD 1UniRule annotation
Gene namesi
Name:ureD1UniRule annotation
Synonyms:ureD-1
Ordered Locus Names:BAB1_0297
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Urease accessory protein UreD 1PRO_0000340419Add
BLAST

Interactioni

Subunit structurei

UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the UreD family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0829.
HOGENOMiHOG000263489.
KOiK03190.
OMAiMARFCAQ.
OrthoDBiEOG6W9X5J.

Family and domain databases

HAMAPiMF_01384. UreD.
InterProiIPR002669. UreD.
[Graphical view]
PfamiPF01774. UreD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YPD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIINDNNLS GLSLQRVNGT GELSVQFKDG RSRISRLYQE GAAKIRMPQA
60 70 80 90 100
VTGPLEAILI NTSGGLTGGD RLKWDVALDD GASAVITTQA CERIYRSGGG
110 120 130 140 150
EARIATRLKA AKGTRLAWLP QETILFNRSI LSRRLDVELE EGAQMLVVEA
160 170 180 190 200
TVFGRLAMGE RVVAARFADR WRVRLGGRVI HAEEFRLGPD VGAELQAPAV
210 220 230 240 250
AGGACAMATV LMVCEQAGRY LETARAIIGE EGGCSLWRVG KASKLVVRLY
260 270 280
APDSYALRRR LCPLVALLNG KAGLPKVWTI
Length:280
Mass (Da):30,256
Last modified:February 7, 2006 - v1
Checksum:i3FE5CA77016C952C
GO

Sequence cautioni

The sequence AAK51066.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361941 Genomic DNA. Translation: AAK51066.1. Different initiation.
AM040264 Genomic DNA. Translation: CAJ10253.1.
RefSeqiWP_002963430.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ10253; CAJ10253; BAB1_0297.
GeneIDi3789049.
KEGGibmf:BAB1_0297.
PATRICi17843460. VBIBruMel86222_0316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361941 Genomic DNA. Translation: AAK51066.1. Different initiation.
AM040264 Genomic DNA. Translation: CAJ10253.1.
RefSeqiWP_002963430.1. NZ_KN046823.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ10253; CAJ10253; BAB1_0297.
GeneIDi3789049.
KEGGibmf:BAB1_0297.
PATRICi17843460. VBIBruMel86222_0316.

Phylogenomic databases

eggNOGiCOG0829.
HOGENOMiHOG000263489.
KOiK03190.
OMAiMARFCAQ.
OrthoDBiEOG6W9X5J.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-303-MONOMER.
BMEL359391:GJOQ-303-MONOMER.

Family and domain databases

HAMAPiMF_01384. UreD.
InterProiIPR002669. UreD.
[Graphical view]
PfamiPF01774. UreD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium."
    Sangari F.J., Seoane A., Rodriguez M.C., Aguero J., Garcia Lobo J.M.
    Infect. Immun. 75:774-780(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ROLE IN VIRULENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiURED1_BRUA2
AccessioniPrimary (citable) accession number: Q2YPD8
Secondary accession number(s): Q93T84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 7, 2006
Last modified: July 22, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.