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Q2YPD8 (URED1_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Urease accessory protein UreD 1
Gene names
Name:ureD1
Synonyms:ureD-1
Ordered Locus Names:BAB1_0297
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter By similarity. Ref.1

Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral. Ref.1

Subunit structure

UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01384.

Sequence similarities

Belongs to the UreD family.

Sequence caution

The sequence AAK51066.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processNickel insertion
Virulence
   Cellular componentCytoplasm
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processnitrogen compound metabolic process

Inferred from electronic annotation. Source: InterPro

pathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionnickel cation binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Urease accessory protein UreD 1 HAMAP-Rule MF_01384
PRO_0000340419

Sequences

Sequence LengthMass (Da)Tools
Q2YPD8 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 3FE5CA77016C952C

FASTA28030,256
        10         20         30         40         50         60 
MLIINDNNLS GLSLQRVNGT GELSVQFKDG RSRISRLYQE GAAKIRMPQA VTGPLEAILI 

        70         80         90        100        110        120 
NTSGGLTGGD RLKWDVALDD GASAVITTQA CERIYRSGGG EARIATRLKA AKGTRLAWLP 

       130        140        150        160        170        180 
QETILFNRSI LSRRLDVELE EGAQMLVVEA TVFGRLAMGE RVVAARFADR WRVRLGGRVI 

       190        200        210        220        230        240 
HAEEFRLGPD VGAELQAPAV AGGACAMATV LMVCEQAGRY LETARAIIGE EGGCSLWRVG 

       250        260        270        280 
KASKLVVRLY APDSYALRRR LCPLVALLNG KAGLPKVWTI 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium."
Sangari F.J., Seoane A., Rodriguez M.C., Aguero J., Garcia Lobo J.M.
Infect. Immun. 75:774-780(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ROLE IN VIRULENCE.
[2]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF361941 Genomic DNA. Translation: AAK51066.1. Different initiation.
AM040264 Genomic DNA. Translation: CAJ10253.1.
RefSeqYP_413768.1. NC_007618.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_0297.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ10253; CAJ10253; BAB1_0297.
GeneID3789049.
KEGGbmf:BAB1_0297.
PATRIC17843460. VBIBruMel86222_0316.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0829.
HOGENOMHOG000263489.
KOK03190.
OMAILFDRAR.
OrthoDBEOG6W9X5J.

Enzyme and pathway databases

BioCycBABO359391:GKDV-303-MONOMER.
BMEL359391:GJOQ-303-MONOMER.

Family and domain databases

HAMAPMF_01384. UreD.
InterProIPR002669. UreD.
[Graphical view]
PfamPF01774. UreD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameURED1_BRUA2
AccessionPrimary (citable) accession number: Q2YPD8
Secondary accession number(s): Q93T84
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names