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Q2YPD8

- URED1_BRUA2

UniProt

Q2YPD8 - URED1_BRUA2

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Protein

Urease accessory protein UreD 1

Gene

ureD1

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.UniRule annotation
Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral.1 Publication

GO - Molecular functioni

  1. nickel cation binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. nitrogen compound metabolic process Source: InterPro
  2. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Nickel insertion, Virulence

Enzyme and pathway databases

BioCyciBABO359391:GKDV-303-MONOMER.
BMEL359391:GJOQ-303-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease accessory protein UreD 1UniRule annotation
Gene namesi
Name:ureD1UniRule annotation
Synonyms:ureD-1
Ordered Locus Names:BAB1_0297
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Urease accessory protein UreD 1PRO_0000340419Add
BLAST

Interactioni

Subunit structurei

UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB1_0297.

Family & Domainsi

Sequence similaritiesi

Belongs to the UreD family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0829.
HOGENOMiHOG000263489.
KOiK03190.
OMAiILFDRAR.
OrthoDBiEOG6W9X5J.

Family and domain databases

HAMAPiMF_01384. UreD.
InterProiIPR002669. UreD.
[Graphical view]
PfamiPF01774. UreD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YPD8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLIINDNNLS GLSLQRVNGT GELSVQFKDG RSRISRLYQE GAAKIRMPQA
60 70 80 90 100
VTGPLEAILI NTSGGLTGGD RLKWDVALDD GASAVITTQA CERIYRSGGG
110 120 130 140 150
EARIATRLKA AKGTRLAWLP QETILFNRSI LSRRLDVELE EGAQMLVVEA
160 170 180 190 200
TVFGRLAMGE RVVAARFADR WRVRLGGRVI HAEEFRLGPD VGAELQAPAV
210 220 230 240 250
AGGACAMATV LMVCEQAGRY LETARAIIGE EGGCSLWRVG KASKLVVRLY
260 270 280
APDSYALRRR LCPLVALLNG KAGLPKVWTI
Length:280
Mass (Da):30,256
Last modified:February 7, 2006 - v1
Checksum:i3FE5CA77016C952C
GO

Sequence cautioni

The sequence AAK51066.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361941 Genomic DNA. Translation: AAK51066.1. Different initiation.
AM040264 Genomic DNA. Translation: CAJ10253.1.
RefSeqiYP_413768.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ10253; CAJ10253; BAB1_0297.
GeneIDi3789049.
KEGGibmf:BAB1_0297.
PATRICi17843460. VBIBruMel86222_0316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361941 Genomic DNA. Translation: AAK51066.1 . Different initiation.
AM040264 Genomic DNA. Translation: CAJ10253.1 .
RefSeqi YP_413768.1. NC_007618.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_0297.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ10253 ; CAJ10253 ; BAB1_0297 .
GeneIDi 3789049.
KEGGi bmf:BAB1_0297.
PATRICi 17843460. VBIBruMel86222_0316.

Phylogenomic databases

eggNOGi COG0829.
HOGENOMi HOG000263489.
KOi K03190.
OMAi ILFDRAR.
OrthoDBi EOG6W9X5J.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-303-MONOMER.
BMEL359391:GJOQ-303-MONOMER.

Family and domain databases

HAMAPi MF_01384. UreD.
InterProi IPR002669. UreD.
[Graphical view ]
Pfami PF01774. UreD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium."
    Sangari F.J., Seoane A., Rodriguez M.C., Aguero J., Garcia Lobo J.M.
    Infect. Immun. 75:774-780(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ROLE IN VIRULENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiURED1_BRUA2
AccessioniPrimary (citable) accession number: Q2YPD8
Secondary accession number(s): Q93T84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 7, 2006
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3