Q2YPD8 (URED1_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urease accessory protein UreD 1

Gene names

Name:	ureD1
Synonyms:	ureD-1
Ordered Locus Names:	BAB1_0297

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter By similarity. Ref.1 Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral. Ref.1
Subunit structure	UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the UreD family.
Sequence caution	The sequence AAK51066.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Nickel insertion Virulence
Cellular component	Cytoplasm
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nickel cation binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Urease accessory protein UreD 1 HAMAP-Rule MF_01384		PRO_0000340419

Sequences

	Sequence		Length	Mass (Da)
	Q2YPD8 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 3FE5CA77016C952C	FASTA	280	30,256
	10 20 30 40 50 60 MLIINDNNLS GLSLQRVNGT GELSVQFKDG RSRISRLYQE GAAKIRMPQA VTGPLEAILI 70 80 90 100 110 120 NTSGGLTGGD RLKWDVALDD GASAVITTQA CERIYRSGGG EARIATRLKA AKGTRLAWLP 130 140 150 160 170 180 QETILFNRSI LSRRLDVELE EGAQMLVVEA TVFGRLAMGE RVVAARFADR WRVRLGGRVI 190 200 210 220 230 240 HAEEFRLGPD VGAELQAPAV AGGACAMATV LMVCEQAGRY LETARAIIGE EGGCSLWRVG 250 260 270 280 KASKLVVRLY APDSYALRRR LCPLVALLNG KAGLPKVWTI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium." Sangari F.J., Seoane A., Rodriguez M.C., Aguero J., Garcia Lobo J.M. Infect. Immun. 75:774-780(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ROLE IN VIRULENCE.
[2]	"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF361941 Genomic DNA. Translation: AAK51066.1. Different initiation. AM040264 Genomic DNA. Translation: CAJ10253.1.
RefSeq	YP_413768.1. NC_007618.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB1_0297.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ10253; CAJ10253; BAB1_0297.
GeneID	3789049.
KEGG	bmf:BAB1_0297.
PATRIC	17843460. VBIBruMel86222_0316.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0829.
HOGENOM	HOG000263489.
KO	K03190.
OMA	QETILFD.
ProtClustDB	CLSK864153.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-303-MONOMER.
Family and domain databases
HAMAP	MF_01384. UreD.
InterPro	IPR002669. UreD. [Graphical view]
Pfam	PF01774. UreD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

URED1_BRUA2

Accession

Primary (citable) accession number: Q2YPD8
Secondary accession number(s): Q93T84

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program