Reviewed, UniProtKB/Swiss-Prot Q2YPD7 (URE31_BRUA2)

Names and origin

Protein names

Recommended name:
    Urease subunit gamma 1
    EC=3.5.1.5
Alternative name(s):
    Urea amidohydrolase subunit gamma 1

Gene names

Name:	ureA1
Synonyms:	ureA, ureA-1
Ordered Locus Names:	BAB1_0298

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	100 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral. Ref.1
Catalytic activity	Urea + H2O = CO2 + 2 NH3. HAMAP MF_00739
Pathway	Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. HAMAP MF_00739
Subunit structure	Heterotrimer of ureA (gamma), ureB (beta) and ureC (alpha) subunits. Three heterotrimers associate to form the active enzyme By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the urease gamma subunit family.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW urea metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel ion binding Inferred from electronic annotation. Source: InterPro urease activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 100	100	Urease subunit gamma 1 HAMAP MF_00739		PRO_0000097999

Sequences

	Sequence		Length	Mass (Da)
	Q2YPD7-1 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 98BAAAE973961FE1	FASTA	100	11,103
	10 20 30 40 50 60 MNLTPREKDK LLIAMAAMVA RRRLERGVKL NHPEAIALVS DFVVEGARDG RTVAELMEAG 70 80 90 100 AHVITREQVM DGVAEMIRDI QVEATFPDGT KLVTVHEPIR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium." Sangari F.J., Seoane A., Rodriguez M.C., Aguero J., Garcia Lobo J.M. Infect. Immun. 75:774-780(2007) [PubMed: 17101645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION OF ROLE IN VIRULENCE.
[2]	"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF361941 Genomic DNA. Translation: AAK51067.1. AM040264 Genomic DNA. Translation: CAJ10254.1.
RefSeq	YP_413769.1.
3D structure databases
SMR	Q2YPD7. Positions 1-99.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YPD7.
Genome annotation databases
GeneID	3789045.
GenomeReviews	Gene locus BAB1_0298 in contig AM040264_GR.
KEGG	bmf:BAB1_0298.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG286300.
OMA	EAIAIIS.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0298-MON.
Family and domain databases
HAMAP	MF_00739. [Tree]
InterPro	IPR002026. Urease_alpha/gamma. IPR012010. Urease_gamma. [Graphical view]
Gene3D	G3DSA:3.30.280.10. Urease_gamma_reg. 1 hit.
Pfam	PF00547. Urease_gamma. 1 hit. [Graphical view]
PIRSF	PIRSF001223. Urease_gamma. 1 hit.
ProDom	PD002319. Urease_gamma_reg. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

URE31_BRUA2

Accession

Primary (citable) accession number: Q2YPD7
Secondary accession number(s): Q57F87, Q93T83

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	December 20, 2005
Last modified:	December 15, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)