Q2YPD6 (URE21_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urease subunit beta 1
EC=3.5.1.5

Alternative name(s):
Urea amidohydrolase subunit beta 1

Gene names

Name:	ureB1
Ordered Locus Names:	BAB1_0299

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral. Ref.1
Catalytic activity	Urea + H2O = CO2 + 2 NH3. HAMAP MF_01954
Pathway	Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. HAMAP MF_01954
Subunit structure	Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_01954.
Sequence similarities	Belongs to the urease beta subunit family.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel cation binding Inferred from electronic annotation. Source: InterPro urease activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 101	101	Urease subunit beta 1 HAMAP MF_01954		PRO_0000234234

Sequences

	Sequence		Length	Mass (Da)
	Q2YPD6 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: EC6F5DA786479D39	FASTA	101	11,337
	10 20 30 40 50 60 MIPGEIITLE GDIELNQGQP TVTMRVANTG DRPIQVGSHF HFYEVNAALS FDREKARGQR 70 80 90 100 LDIAAGTAVR FEPGQERDVT LVPIRGHREI YGFRQMIMGK L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium." Sangari F.J., Seoane A., Rodriguez M.C., Aguero J., Garcia Lobo J.M. Infect. Immun. 75:774-780(2007) [PubMed: 17101645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION OF ROLE IN VIRULENCE.
[2]	"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF361941 Genomic DNA. Translation: AAK51068.1. AM040264 Genomic DNA. Translation: CAJ10255.1.
RefSeq	YP_413770.1. NC_007618.1.
3D structure databases
ProteinModelPortal	Q2YPD6.
SMR	Q2YPD6. Positions 1-101.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YPD6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3789047.
GenomeReviews	Gene locus BAB1_0299 in contig AM040264_GR.
KEGG	bmf:BAB1_0299.
PATRIC	17843466. VBIBruMel86222_0319.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0832.
HOGENOM	HBG365918.
OMA	PLSGKRE.
ProtClustDB	PRK13203.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0299-MONOMER.
Family and domain databases
HAMAP	MF_01954. Urease_beta. [Tree]
InterPro	IPR002019. Urease_beta. [Graphical view]
Gene3D	G3DSA:2.10.150.10. Urease_beta. 1 hit.
KO	K01429.
Pfam	PF00699. Urease_beta. 1 hit. [Graphical view]
SUPFAM	SSF51278. Urease_beta. 1 hit.
TIGRFAMs	TIGR00192. Urease_beta. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URE21_BRUA2

Accession

Primary (citable) accession number: Q2YPD6
Secondary accession number(s): Q57F86, Q93T82

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	February 7, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program