Q2YPD2 (UREG1_BRUA2) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 34.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Urease accessory protein UreG 1 | ||||
| Gene names |
| ||||
| Organism | Brucella abortus (strain 2308) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 359391 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 208 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG By similarity. Ref.1 Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral. Ref.1 |
| Subunit structure | Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel By similarity. |
| Subcellular location | Cytoplasm By similarity HAMAP MF_01389. |
| Sequence similarities | Belongs to the UreG family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nickel insertion Virulence |
| Cellular component | Cytoplasm |
| Ligand | GTP-binding Nucleotide-binding |
| Molecular function | Chaperone |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro GTP bindingInferred from electronic annotation. Source: UniProtKB-KW nickel cation bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 208 | 208 | Urease accessory protein UreG 1 HAMAP MF_01389 | PRO_0000347355 | |||||
Regions | |||||||||
| Nucleotide binding | 14 – 21 | 8 | GTP By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium." Sangari F.J., Seoane A., Rodriguez M.C., Aguero J., Garcia Lobo J.M. Infect. Immun. 75:774-780(2007) [PubMed: 17101645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ROLE IN VIRULENCE. |
| [2] | "Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF361941 Genomic DNA. Translation: AAK51072.1. AM040264 Genomic DNA. Translation: CAJ10259.1. |
| RefSeq | YP_413774.1. NC_007618.1. |
3D structure databases | |
| ProteinModelPortal | Q2YPD2. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2YPD2. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3789051. |
| GenomeReviews | Gene locus BAB1_0303 in contig AM040264_GR. |
| KEGG | bmf:BAB1_0303. |
| PATRIC | 17843474. VBIBruMel86222_0323. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0378. |
| HOGENOM | HBG364734. |
| OMA | PFIFTNL. |
| ProtClustDB | CLSK864148. |
Enzyme and pathway databases | |
| BioCyc | BMEL359391:BAB1_0303-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01389. UreG. [Tree] |
| InterPro | IPR003495. Cbl_biosynth_CobW-like. IPR012202. NiFe-hyd/urease_mat_GTPase. IPR004400. Urease_accessory_UreG. [Graphical view] |
| KO | K03189. |
| Pfam | PF02492. cobW. 1 hit. [Graphical view] |
| PIRSF | PIRSF005624. Ni-bind_GTPase. 1 hit. |
| TIGRFAMs | TIGR00101. UreG. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | UREG1_BRUA2 | ||||||||
| Accession | Primary (citable) accession number: Q2YPD2 Secondary accession number(s): Q57F82, Q93T78 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Brucella abortus strain 2308 Brucella abortus (strain 2308): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with