Q2YPD2 (UREG1_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urease accessory protein UreG 1

Gene names

Name:	ureG1
Ordered Locus Names:	BAB1_0303

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG By similarity. Ref.1 Disruption of the ure1 gene cluster suggests that it protects brucellae during their passage through the stomach. The major route of infection in human brucellosis is oral. Ref.1
Subunit structure	Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_01389.
Sequence similarities	Belongs to the UreG family.

Ontologies

Keywords
Biological process	Nickel insertion Virulence
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro GTP binding Inferred from electronic annotation. Source: UniProtKB-KW nickel cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Urease accessory protein UreG 1 HAMAP MF_01389		PRO_0000347355
Regions
	Nucleotide binding	14 – 21	8	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YPD2 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 39FF82812CA4FDE2	FASTA	208	22,705
	10 20 30 40 50 60 MTQKNGPLRV GIGGPVGSGK TTLTEKLCKA MRDKYSVAVI TNDIYTQEDA LILARRQALS 70 80 90 100 110 120 EDRIIGVETG GCPHTAIRED ASINLQAVVE MTRRFPDLDV VFIESGGDNL AATFSPDLAD 130 140 150 160 170 180 LTLYVISVCQ GEEIPRKGGP GITRSDFLVI NKSDLAPYVH VDLEVMEADA MRMRAKRPFG 190 200 FTDLHRGKGV QEIIDFIVEN GGLEPRSN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the urease operon of Brucella abortus and assessment of its role in virulence of the bacterium." Sangari F.J., Seoane A., Rodriguez M.C., Aguero J., Garcia Lobo J.M. Infect. Immun. 75:774-780(2007) [PubMed: 17101645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ROLE IN VIRULENCE.
[2]	"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF361941 Genomic DNA. Translation: AAK51072.1. AM040264 Genomic DNA. Translation: CAJ10259.1.
RefSeq	YP_413774.1. NC_007618.1.
3D structure databases
ProteinModelPortal	Q2YPD2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YPD2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3789051.
GenomeReviews	Gene locus BAB1_0303 in contig AM040264_GR.
KEGG	bmf:BAB1_0303.
PATRIC	17843474. VBIBruMel86222_0323.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0378.
HOGENOM	HBG364734.
OMA	PFIFTNL.
ProtClustDB	CLSK864148.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0303-MONOMER.
Family and domain databases
HAMAP	MF_01389. UreG. [Tree]
InterPro	IPR003495. Cbl_biosynth_CobW-like. IPR012202. NiFe-hyd/urease_mat_GTPase. IPR004400. Urease_accessory_UreG. [Graphical view]
KO	K03189.
Pfam	PF02492. cobW. 1 hit. [Graphical view]
PIRSF	PIRSF005624. Ni-bind_GTPase. 1 hit.
TIGRFAMs	TIGR00101. UreG. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UREG1_BRUA2

Accession

Primary (citable) accession number: Q2YPD2
Secondary accession number(s): Q57F82, Q93T78

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	February 7, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program