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Q2YPC3

- YACG_BRUA2

UniProt

Q2YPC3 - YACG_BRUA2

Protein

DNA gyrase inhibitor YacG

Gene

yacG

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.UniRule annotation

    Cofactori

    Binds 1 zinc ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi10 – 101ZincUniRule annotation
    Metal bindingi13 – 131ZincUniRule annotation
    Metal bindingi25 – 251ZincUniRule annotation
    Metal bindingi29 – 291ZincUniRule annotation

    GO - Molecular functioni

    1. DNA topoisomerase (ATP-hydrolyzing) inhibitor activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-285-MONOMER.
    BMEL359391:GJOQ-285-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA gyrase inhibitor YacGUniRule annotation
    Gene namesi
    Name:yacGUniRule annotation
    Ordered Locus Names:BAB1_0280
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5757DNA gyrase inhibitor YacGPRO_1000056968Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with GyrB.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_0280.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YPC3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA gyrase inhibitor YacG family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3024.
    HOGENOMiHOG000255917.
    KOiK09862.
    OMAiEAWRRES.
    OrthoDBiEOG65F8ZX.

    Family and domain databases

    Gene3Di3.30.50.10. 1 hit.
    HAMAPiMF_00649. DNA_gyrase_inhibitor_YacG.
    InterProiIPR005584. DNA_gyrase_inhibitor_YacG.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF03884. DUF329. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YPC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLRPTRPC PECGKPSTRE AYPFCSPRCK NIDLNRWLSG SYVIAGKPLG   50
    EEDENDS 57
    Length:57
    Mass (Da):6,354
    Last modified:December 20, 2005 - v1
    Checksum:iAE0B63B8A995213D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10236.1.
    RefSeqiYP_413754.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ10236; CAJ10236; BAB1_0280.
    GeneIDi3787065.
    KEGGibmf:BAB1_0280.
    PATRICi17843409. VBIBruMel86222_0292.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10236.1 .
    RefSeqi YP_413754.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YPC3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_0280.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ10236 ; CAJ10236 ; BAB1_0280 .
    GeneIDi 3787065.
    KEGGi bmf:BAB1_0280.
    PATRICi 17843409. VBIBruMel86222_0292.

    Phylogenomic databases

    eggNOGi COG3024.
    HOGENOMi HOG000255917.
    KOi K09862.
    OMAi EAWRRES.
    OrthoDBi EOG65F8ZX.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-285-MONOMER.
    BMEL359391:GJOQ-285-MONOMER.

    Family and domain databases

    Gene3Di 3.30.50.10. 1 hit.
    HAMAPi MF_00649. DNA_gyrase_inhibitor_YacG.
    InterProi IPR005584. DNA_gyrase_inhibitor_YacG.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF03884. DUF329. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiYACG_BRUA2
    AccessioniPrimary (citable) accession number: Q2YPC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3