Q2YPC3 (YACG_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA gyrase inhibitor YacG

Gene names

Name:	yacG
Ordered Locus Names:	BAB1_0280

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	57 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase By similarity. HAMAP-Rule MF_00649
Cofactor	Binds 1 zinc ion By similarity.
Subunit structure	Interacts with GyrB By similarity.
Sequence similarities	Belongs to the DNA gyrase inhibitor YacG family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA topoisomerase (ATP-hydrolyzing) inhibitor activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 57	57	DNA gyrase inhibitor YacG HAMAP-Rule MF_00649		PRO_1000056968
Sites
	Metal binding	10	1	Zinc By similarity
	Metal binding	13	1	Zinc By similarity
	Metal binding	25	1	Zinc By similarity
	Metal binding	29	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YPC3 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: AE0B63B8A995213D	FASTA	57	6,354
	10 20 30 40 50 MAPLRPTRPC PECGKPSTRE AYPFCSPRCK NIDLNRWLSG SYVIAGKPLG EEDENDS

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040264 Genomic DNA. Translation: CAJ10236.1.
RefSeq	YP_413754.1. NC_007618.1.
3D structure databases
ProteinModelPortal	Q2YPC3.
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB1_0280.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ10236; CAJ10236; BAB1_0280.
GeneID	3787065.
KEGG	bmf:BAB1_0280.
PATRIC	17843409. VBIBruMel86222_0292.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3024.
HOGENOM	HOG000255917.
KO	K09862.
OMA	IPAREDE.
ProtClustDB	PRK01343.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-285-MONOMER.
Family and domain databases
Gene3D	3.30.50.10. 1 hit.
HAMAP	MF_00649. DNA_gyrase_inhibitor_YacG.
InterPro	IPR005584. DNA_gyrase_inhibitor_YacG. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF03884. DUF329. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YACG_BRUA2

Accession

Primary (citable) accession number: Q2YPC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program