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Q2YPC3

- YACG_BRUA2

UniProt

Q2YPC3 - YACG_BRUA2

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Protein

DNA gyrase inhibitor YacG

Gene

yacG

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.UniRule annotation

Cofactori

Binds 1 zinc ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi10 – 101ZincUniRule annotation
Metal bindingi13 – 131ZincUniRule annotation
Metal bindingi25 – 251ZincUniRule annotation
Metal bindingi29 – 291ZincUniRule annotation

GO - Molecular functioni

  1. DNA topoisomerase (ATP-hydrolyzing) inhibitor activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBABO359391:GKDV-285-MONOMER.
BMEL359391:GJOQ-285-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA gyrase inhibitor YacGUniRule annotation
Gene namesi
Name:yacGUniRule annotation
Ordered Locus Names:BAB1_0280
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5757DNA gyrase inhibitor YacGPRO_1000056968Add
BLAST

Interactioni

Subunit structurei

Interacts with GyrB.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB1_0280.

Structurei

3D structure databases

ProteinModelPortaliQ2YPC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA gyrase inhibitor YacG family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3024.
HOGENOMiHOG000255917.
KOiK09862.
OMAiEAWRRES.
OrthoDBiEOG65F8ZX.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
HAMAPiMF_00649. DNA_gyrase_inhibitor_YacG.
InterProiIPR005584. DNA_gyrase_inhibitor_YacG.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF03884. DUF329. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YPC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPLRPTRPC PECGKPSTRE AYPFCSPRCK NIDLNRWLSG SYVIAGKPLG

EEDENDS
Length:57
Mass (Da):6,354
Last modified:December 20, 2005 - v1
Checksum:iAE0B63B8A995213D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ10236.1.
RefSeqiWP_002967123.1. NC_007618.1.
YP_413754.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ10236; CAJ10236; BAB1_0280.
GeneIDi3787065.
KEGGibmf:BAB1_0280.
PATRICi17843409. VBIBruMel86222_0292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ10236.1 .
RefSeqi WP_002967123.1. NC_007618.1.
YP_413754.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YPC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_0280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ10236 ; CAJ10236 ; BAB1_0280 .
GeneIDi 3787065.
KEGGi bmf:BAB1_0280.
PATRICi 17843409. VBIBruMel86222_0292.

Phylogenomic databases

eggNOGi COG3024.
HOGENOMi HOG000255917.
KOi K09862.
OMAi EAWRRES.
OrthoDBi EOG65F8ZX.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-285-MONOMER.
BMEL359391:GJOQ-285-MONOMER.

Family and domain databases

Gene3Di 3.30.50.10. 1 hit.
HAMAPi MF_00649. DNA_gyrase_inhibitor_YacG.
InterProi IPR005584. DNA_gyrase_inhibitor_YacG.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF03884. DUF329. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiYACG_BRUA2
AccessioniPrimary (citable) accession number: Q2YPC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3