Reviewed, UniProtKB/Swiss-Prot Q2YPC1 (IF1_BRUA2)

Names and origin

Protein names

Recommended name:
    Translation initiation factor IF-1

Gene names

Name:	infA
Ordered Locus Names:	BAB1_0282

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	72 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	No specific function has so far been attributed to this initiation factor; however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3. HAMAP MF_00075
Subcellular location	Cytoplasm.
Induction	It is induced 4 hours after macrophage infection. Ref.1
Sequence similarities	Belongs to the IF-1 family. Contains 1 S1-like domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translational initiation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: HAMAP translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 72	72	Translation initiation factor IF-1 HAMAP MF_00075		PRO_0000095753
Regions
	Domain	1 – 72	72	S1-like

Sequences

	Sequence		Length	Mass (Da)
	Q2YPC1-1 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 67D1320EB09AE093	FASTA	72	8,372
	10 20 30 40 50 60 MAKEEVLEFP GVVTELLPNA MFRVKLENEH EIIAHTAGRM RKNRIRVLAG DKVLVEMTPY 70 DLTKGRITYR FK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Brucella abortus genes identified following constitutive growth and macrophage infection." Eskra L., Canavessi A., Carey M., Splitter G.A. Infect. Immun. 69:7736-7742(2001) [PubMed: 11705955] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
[2]	"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF288531 Genomic DNA. Translation: AAK11548.1. AM040264 Genomic DNA. Translation: CAJ10238.1.
RefSeq	YP_413756.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YPC1.
Genome annotation databases
GeneID	3787066.
GenomeReviews	Gene locus BAB1_0282 in contig AM040264_GR.
KEGG	bmf:BAB1_0282.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2YPC1.
OMA	VQLDAGH
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0282-MON.
Family and domain databases
HAMAP	MF_00075. [Tree]
InterPro	IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR006196. S1_IF1. IPR004368. TIF_IF1. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
Pfam	PF01176. eIF-1a. 1 hit. [Graphical view]
TIGRFAMs	TIGR00008. infA. 1 hit.
PROSITE	PS50832. S1_IF1_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF1_BRUA2

Accession

Primary (citable) accession number: Q2YPC1
Secondary accession number(s): P62922 , Q57FA2, Q8YF56, Q9ACA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	December 20, 2005
Last modified:	November 24, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)