Reviewed, UniProtKB/Swiss-Prot Q2YP58 (THIG_BRUA2)

Names and origin

Protein names

Recommended name:
    Thiazole biosynthesis protein thiG

Gene names

Name:	thiG
Ordered Locus Names:	BAB1_0216

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Required for the synthesis of the thiazole moiety of thiamine By similarity.
Cofactor	FMN Potential.
Pathway	Cofactor biosynthesis; thiamine diphosphate biosynthesis. HAMAP MF_00443
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the thiG family.

Ontologies

Keywords
Biological process	Thiamine biosynthesis
Cellular component	Cytoplasm
Ligand	FMN Flavoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Thiazole biosynthesis protein thiG HAMAP MF_00443		PRO_0000236333

Sequences

	Sequence		Length	Mass (Da)
	Q2YP58-1 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: B4BB05AAAF6E0510	FASTA	256	27,321
	10 20 30 40 50 60 MLEFYGKRFE SRLLLGTAQY PSPSILADAV RASLSRIVTV SLRRESGEAR AGQDFWALIK 70 80 90 100 110 120 ALGVAVLPNT AGCHTPREAI TTAHMAREVF GTNWIKLEVI GDTDTLQPDP FGLVEAARIL 130 140 150 160 170 180 CDEGFEVFPY MNDDLIVAER LIEAGCKVLM PWGAPIGSGR GLNNPYALKT MRAHFPDIPL 190 200 210 220 230 240 VVDAGIGVPS HAAAAMELGF DAVLINTAVA KAGDPAAMAR AFALAVEAGR LAYEADPIEA 250 RDMASPSTPL LGKAFL

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM040264 Genomic DNA. Translation: CAJ10172.1.
RefSeq	YP_413698.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YP58.
Genome annotation databases
GeneID	3787004.
GenomeReviews	Gene locus BAB1_0216 in contig AM040264_GR.
KEGG	bmf:BAB1_0216.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG296821.
OMA	VAIRRTN.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0216-MON.
Family and domain databases
HAMAP	MF_00443. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR008867. ThiG. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF05690. ThiG. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THIG_BRUA2

Accession

Primary (citable) accession number: Q2YP58

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	December 20, 2005
Last modified:	December 15, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)