Q2YNZ0 (MUTS_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein mutS

Gene names

Name:	mutS
Ordered Locus Names:	BAB1_0146

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	910 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity By similarity. HAMAP MF_00096
Sequence similarities	Belongs to the DNA mismatch repair mutS family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mismatch repair Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 910	910	DNA mismatch repair protein mutS HAMAP MF_00096		PRO_0000335122
Regions
	Nucleotide binding	658 – 665	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2YNZ0 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: F229CA143565CB47	FASTA	910	98,836
	10 20 30 40 50 60 MEAKVEEKEP EPVENAGPDA PVRLTPMMEQ YIEIKAANVD SLLFYRMGDF YELFFDDAVA 70 80 90 100 110 120 ASAALGITLT KRGKHLGEDI PMCGVPVHAA DDYLQKLIAK GYRVAVCEQV EDPAEAKKRG 130 140 150 160 170 180 SKSVVKRDVI RLVTPGTLTE EKLLDPAQAN FLMAMGRTRG DGALALVWID ISTGTFRVAE 190 200 210 220 230 240 TTPDRLFADI MRVDPRELVV ADSAFHDEEL RPVFDLIGKA VTPQPATLFD SAAAQTRIQH 250 260 270 280 290 300 YFNVATLDGF GQFSRPELSA ISGAIAYIEK TQISERPPLM RPEREHEGGT LFIDPATRAS 310 320 330 340 350 360 LELARTMSGN RDGSLLKAID RTVTGGGARL LAERLTAPLT SPKEIALRLD SVSWCLSEQT 370 380 390 400 410 420 LCEALRLELK GVPDMPRALS RLAVGRGGPR DLGALACGFE AAGGIASLLD GALLPDELAA 430 440 450 460 470 480 AREAIEKMPA GFAAHLDRAL ADELPLLKRD GGFVREGYNS ELDEMRALRD QSRRVIAGLQ 490 500 510 520 530 540 ADYIEETGIK SLKIKHNNVL GYFIEVTANN SGAMTDTDEA KSRFIHRQTM ANAMRFTTTE 550 560 570 580 590 600 LAELESKIAN AADRALSIEL AIFEELTAEA VAHADSIRAA ASALSVFDVS TALAVLAEEQ 610 620 630 640 650 660 GYCRPHVDDS LSFNIVAGRH PVVEQALRRQ AANPFVANDC DLSPQRDGGD GAIWLLTGPN 670 680 690 700 710 720 MGGKSTFLRQ NALIAILAQM GSFVPAGSAH IGVVDRLFSR VGASDDLARG RSTFMVEMVE 730 740 750 760 770 780 TAAILNQAGE HSLVILDEIG RGTATFDGLS IAWAAVEYLH EKNRCRALFA THFHEMTALS 790 800 810 820 830 840 EKLERLSNVT MRVKEWDNDV IFLHEVAKGA ADRSYGVQVA RLAGLPEAVV NRARDVLHQL 850 860 870 880 890 900 EAGETSGKAD RLIDDLPLFS VMLQQEKPKP QIQAKDSELA NAVAAISPDE LTPREALDLI 910 YKLKELAGKA

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040264 Genomic DNA. Translation: CAJ10102.1.
RefSeq	YP_413636.1. NC_007618.1.
3D structure databases
HSSP	HSSP built from PDB template 1WBD based on UniProtKB P23909.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YNZ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3786946.
GenomeReviews	Gene locus BAB1_0146 in contig AM040264_GR.
KEGG	bmf:BAB1_0146.
PATRIC	17843125. VBIBruMel86222_0154.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0249.
HOGENOM	HBG735169.
OMA	DFFECFF.
ProtClustDB	PRK05399.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0146-MONOMER.
Family and domain databases
HAMAP	MF_00096. MutS. [Tree]
InterPro	IPR005748. DNA_mismatch_repair_MutS-1. IPR007695. DNA_mismatch_repair_MutS-lik_N. IPR000432. DNA_mismatch_repair_MutS_C. IPR007861. DNA_mismatch_repair_MutS_clamp. IPR007860. DNA_mismatch_repair_MutS_connt. IPR007696. DNA_mismatch_repair_MutS_core. IPR016151. DNA_mismatch_repair_MutS_N. [Graphical view]
Gene3D	G3DSA:3.30.420.110. DNA_mismatch_repair_MutS_connt. 1 hit. G3DSA:3.40.1170.10. DNA_mismatch_repair_MutS_N. 1 hit.
KO	K03555.
PANTHER	PTHR11361:SF34. PTHR11361:SF34. 1 hit.
Pfam	PF01624. MutS_I. 1 hit. PF05188. MutS_II. 1 hit. PF05192. MutS_III. 1 hit. PF05190. MutS_IV. 1 hit. PF00488. MutS_V. 1 hit. [Graphical view]
SMART	SM00534. MUTSac. 1 hit. SM00533. MUTSd. 1 hit. [Graphical view]
SUPFAM	SSF53150. DNA_mismatch_repair_MutS_connt. 1 hit. SSF55271. DNA_mismatch_repair_MutS_N. 1 hit. SSF48334. DNA_repair_MutS_domIII. 1 hit.
TIGRFAMs	TIGR01070. MutS1. 1 hit.
PROSITE	PS00486. DNA_MISMATCH_REPAIR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTS_BRUA2

Accession

Primary (citable) accession number: Q2YNZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 7, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program