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Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi658 – 665ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutSUniRule annotation
Gene namesi
Name:mutSUniRule annotation
Ordered Locus Names:BAB1_0146
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003351221 – 910DNA mismatch repair protein MutSAdd BLAST910

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000221407.
KOiK03555.
OMAiCLLLFRM.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS. 1 hit.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YNZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAKVEEKEP EPVENAGPDA PVRLTPMMEQ YIEIKAANVD SLLFYRMGDF
60 70 80 90 100
YELFFDDAVA ASAALGITLT KRGKHLGEDI PMCGVPVHAA DDYLQKLIAK
110 120 130 140 150
GYRVAVCEQV EDPAEAKKRG SKSVVKRDVI RLVTPGTLTE EKLLDPAQAN
160 170 180 190 200
FLMAMGRTRG DGALALVWID ISTGTFRVAE TTPDRLFADI MRVDPRELVV
210 220 230 240 250
ADSAFHDEEL RPVFDLIGKA VTPQPATLFD SAAAQTRIQH YFNVATLDGF
260 270 280 290 300
GQFSRPELSA ISGAIAYIEK TQISERPPLM RPEREHEGGT LFIDPATRAS
310 320 330 340 350
LELARTMSGN RDGSLLKAID RTVTGGGARL LAERLTAPLT SPKEIALRLD
360 370 380 390 400
SVSWCLSEQT LCEALRLELK GVPDMPRALS RLAVGRGGPR DLGALACGFE
410 420 430 440 450
AAGGIASLLD GALLPDELAA AREAIEKMPA GFAAHLDRAL ADELPLLKRD
460 470 480 490 500
GGFVREGYNS ELDEMRALRD QSRRVIAGLQ ADYIEETGIK SLKIKHNNVL
510 520 530 540 550
GYFIEVTANN SGAMTDTDEA KSRFIHRQTM ANAMRFTTTE LAELESKIAN
560 570 580 590 600
AADRALSIEL AIFEELTAEA VAHADSIRAA ASALSVFDVS TALAVLAEEQ
610 620 630 640 650
GYCRPHVDDS LSFNIVAGRH PVVEQALRRQ AANPFVANDC DLSPQRDGGD
660 670 680 690 700
GAIWLLTGPN MGGKSTFLRQ NALIAILAQM GSFVPAGSAH IGVVDRLFSR
710 720 730 740 750
VGASDDLARG RSTFMVEMVE TAAILNQAGE HSLVILDEIG RGTATFDGLS
760 770 780 790 800
IAWAAVEYLH EKNRCRALFA THFHEMTALS EKLERLSNVT MRVKEWDNDV
810 820 830 840 850
IFLHEVAKGA ADRSYGVQVA RLAGLPEAVV NRARDVLHQL EAGETSGKAD
860 870 880 890 900
RLIDDLPLFS VMLQQEKPKP QIQAKDSELA NAVAAISPDE LTPREALDLI
910
YKLKELAGKA
Length:910
Mass (Da):98,836
Last modified:February 7, 2006 - v1
Checksum:iF229CA143565CB47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ10102.1.
RefSeqiWP_002965395.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ10102; CAJ10102; BAB1_0146.
GeneIDi3786946.
KEGGibmf:BAB1_0146.
PATRICi17843125. VBIBruMel86222_0154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ10102.1.
RefSeqiWP_002965395.1. NZ_KN046823.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ10102; CAJ10102; BAB1_0146.
GeneIDi3786946.
KEGGibmf:BAB1_0146.
PATRICi17843125. VBIBruMel86222_0154.

Phylogenomic databases

HOGENOMiHOG000221407.
KOiK03555.
OMAiCLLLFRM.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS. 1 hit.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUTS_BRUA2
AccessioniPrimary (citable) accession number: Q2YNZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 7, 2006
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.