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Q2YNZ0 (MUTS_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA mismatch repair protein mutS
Gene names
Name:mutS
Ordered Locus Names:BAB1_0146
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length910 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity By similarity. HAMAP MF_00096

Sequence similarities

Belongs to the DNA mismatch repair mutS family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmismatch repair

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

mismatched DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 910910DNA mismatch repair protein mutS HAMAP MF_00096
PRO_0000335122

Regions

Nucleotide binding658 – 6658ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q2YNZ0 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: F229CA143565CB47

FASTA91098,836
        10         20         30         40         50         60 
MEAKVEEKEP EPVENAGPDA PVRLTPMMEQ YIEIKAANVD SLLFYRMGDF YELFFDDAVA 

        70         80         90        100        110        120 
ASAALGITLT KRGKHLGEDI PMCGVPVHAA DDYLQKLIAK GYRVAVCEQV EDPAEAKKRG 

       130        140        150        160        170        180 
SKSVVKRDVI RLVTPGTLTE EKLLDPAQAN FLMAMGRTRG DGALALVWID ISTGTFRVAE 

       190        200        210        220        230        240 
TTPDRLFADI MRVDPRELVV ADSAFHDEEL RPVFDLIGKA VTPQPATLFD SAAAQTRIQH 

       250        260        270        280        290        300 
YFNVATLDGF GQFSRPELSA ISGAIAYIEK TQISERPPLM RPEREHEGGT LFIDPATRAS 

       310        320        330        340        350        360 
LELARTMSGN RDGSLLKAID RTVTGGGARL LAERLTAPLT SPKEIALRLD SVSWCLSEQT 

       370        380        390        400        410        420 
LCEALRLELK GVPDMPRALS RLAVGRGGPR DLGALACGFE AAGGIASLLD GALLPDELAA 

       430        440        450        460        470        480 
AREAIEKMPA GFAAHLDRAL ADELPLLKRD GGFVREGYNS ELDEMRALRD QSRRVIAGLQ 

       490        500        510        520        530        540 
ADYIEETGIK SLKIKHNNVL GYFIEVTANN SGAMTDTDEA KSRFIHRQTM ANAMRFTTTE 

       550        560        570        580        590        600 
LAELESKIAN AADRALSIEL AIFEELTAEA VAHADSIRAA ASALSVFDVS TALAVLAEEQ 

       610        620        630        640        650        660 
GYCRPHVDDS LSFNIVAGRH PVVEQALRRQ AANPFVANDC DLSPQRDGGD GAIWLLTGPN 

       670        680        690        700        710        720 
MGGKSTFLRQ NALIAILAQM GSFVPAGSAH IGVVDRLFSR VGASDDLARG RSTFMVEMVE 

       730        740        750        760        770        780 
TAAILNQAGE HSLVILDEIG RGTATFDGLS IAWAAVEYLH EKNRCRALFA THFHEMTALS 

       790        800        810        820        830        840 
EKLERLSNVT MRVKEWDNDV IFLHEVAKGA ADRSYGVQVA RLAGLPEAVV NRARDVLHQL 

       850        860        870        880        890        900 
EAGETSGKAD RLIDDLPLFS VMLQQEKPKP QIQAKDSELA NAVAAISPDE LTPREALDLI 

       910 
YKLKELAGKA 

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References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ10102.1.
RefSeqYP_413636.1. NC_007618.1.

3D structure databases

HSSPHSSP built from PDB template 1WBD based on UniProtKB P23909.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2YNZ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3786946.
GenomeReviewsGene locus BAB1_0146 in contig AM040264_GR.
KEGGbmf:BAB1_0146.
PATRIC17843125. VBIBruMel86222_0154.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0249.
HOGENOMHBG735169.
OMADFFECFF.
ProtClustDBPRK05399.

Enzyme and pathway databases

BioCycBMEL359391:BAB1_0146-MONOMER.

Family and domain databases

HAMAPMF_00096. MutS.
[Tree]
InterProIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007860. DNA_mismatch_repair_MutS_connt.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
[Graphical view]
Gene3DG3DSA:3.30.420.110. DNA_mismatch_repair_MutS_connt. 1 hit.
G3DSA:3.40.1170.10. DNA_mismatch_repair_MutS_N. 1 hit.
KOK03555.
PANTHERPTHR11361:SF34. PTHR11361:SF34. 1 hit.
PfamPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMSSF53150. DNA_mismatch_repair_MutS_connt. 1 hit.
SSF55271. DNA_mismatch_repair_MutS_N. 1 hit.
SSF48334. DNA_repair_MutS_domIII. 1 hit.
TIGRFAMsTIGR01070. MutS1. 1 hit.
PROSITEPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUTS_BRUA2
AccessionPrimary (citable) accession number: Q2YNZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 7, 2006
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names

SIMILARITY comments

Index of protein domains and families