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Q2YNV6

- PNCB_BRUA2

UniProt

Q2YNV6 - PNCB_BRUA2

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-111-MONOMER.
    BMEL359391:GJOQ-111-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:BAB1_0109
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Nicotinate phosphoribosyltransferasePRO_1000024995Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB1_0109.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YNV6.
    SMRiQ2YNV6. Positions 1-426.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284929.
    KOiK00763.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YNV6-1 [UniParc]FASTAAdd to Basket

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    MAKTDLARRV YNHTWKLDPI IRSLLDTDFY KLLMLQMIWG LYPRVDATFS    50
    LINRTSSVRL ADEIDEGELR AQLDHARTLR FSKKEMIWLA GNTFYGRKQI 100
    FQPEFLAWLH DFQLPEYELR RKDGQYELHF HGPWTHTTMW EIPALAIINE 150
    LRSRAAMKNL GPFSLDVLYA RAKAKMWSKV ERLRQLPDLK ISDFGTRRRH 200
    SFLWQRWCVE ALKEGIGSAF TGTSNVLLAM DTDLEALGTN AHELPMVLAA 250
    LAKTDDELRS APYRVLQDWN RYYGGNLLIV LPDAFGTAAF LRNAPDWVAD 300
    WTGFRPDSAP PIEGGERIIE WWKSKGKDPR EKLLIFSDAL DVDTIEETYR 350
    HFEGRVRMGF GWGTNLTNDF AGCAPQSIDG LKAISLVCKV TDANGHPAVK 400
    LSDNPQKATG DPKEVARYLR FFGNEERVEQ LVRV 434
    Length:434
    Mass (Da):49,909
    Last modified:February 7, 2006 - v1
    Checksum:iA11BE6474B58F0C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10065.1.
    RefSeqiYP_413605.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ10065; CAJ10065; BAB1_0109.
    GeneIDi3788859.
    KEGGibmf:BAB1_0109.
    PATRICi17843049. VBIBruMel86222_0116.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10065.1 .
    RefSeqi YP_413605.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YNV6.
    SMRi Q2YNV6. Positions 1-426.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_0109.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ10065 ; CAJ10065 ; BAB1_0109 .
    GeneIDi 3788859.
    KEGGi bmf:BAB1_0109.
    PATRICi 17843049. VBIBruMel86222_0116.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284929.
    KOi K00763.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci BABO359391:GKDV-111-MONOMER.
    BMEL359391:GJOQ-111-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiPNCB_BRUA2
    AccessioniPrimary (citable) accession number: Q2YNV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3