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Q2YNG6 (PURL_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 2

EC=6.3.5.3
Alternative name(s):
Phosphoribosylformylglycinamidine synthase II
Short name=FGAM synthase II
Gene names
Name:purL
Ordered Locus Names:BAB1_0857
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length740 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00420

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00420

Subunit structure

Heterodimer of two subunits, PurQ and PurL By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00420.

Sequence similarities

Belongs to the FGAMS family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphoribosylformylglycinamidine synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 740740Phosphoribosylformylglycinamidine synthase 2 HAMAP-Rule MF_00420
PRO_0000236649

Regions

Nucleotide binding107 – 11812ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q2YNG6 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: C59E25D61D763D78

FASTA74079,148
        10         20         30         40         50         60 
MTISNTRDIT PELIEAHGLK PDEYQRILEL IGREPTFTEL GIFSAMWNEH CSYKSSKKWL 

        70         80         90        100        110        120 
RTLPTSGPRV IQGPGENAGV VDIGDGDCVV FKMESHNHPS YIEPYQGAAT GVGGILRDVF 

       130        140        150        160        170        180 
TMGARPVAAM NALRFGEPDH PKTRHLVSGV VSGVGGYGNA FGVPTVGGEV NFDKRYNGNI 

       190        200        210        220        230        240 
LVNAFAAGLA RHDGIFLSEA EGVGLPVVYL GAKTSRDGVG GATMASAEFD ESIEEKRPTV 

       250        260        270        280        290        300 
QVGDPFTEKC LLEACLELMA SGAVIAIQDM GAAGLTCSAV EMGAKGDLGI ELILDHVPVR 

       310        320        330        340        350        360 
EENMTAYEMM LSESQERMLM VLKPEKEAEA QAIFRKWGLD FAIVGKTTDD LRFRVIHQGE 

       370        380        390        400        410        420 
EVANLPIKDL GDEAPEYDRP WMEPGKHAPL PASNVPQVED YSAALLKLIG SPDLSSRRWV 

       430        440        450        460        470        480 
YEQYDTLIQG NSLQVPGGDA GVIRVEGHET KALAFSSDVT PRYCEADPFE GGKQAVAECW 

       490        500        510        520        530        540 
RNITATGAEP LASTDNLNFG NPEKPEIMGQ LVKAIEGIGE ACRALDFPIV SGNVSLYNET 

       550        560        570        580        590        600 
NGQAILPTPT IAGVGLLPDW SQMAKIGGMQ DGDTLVLLGG DGTHLGQSVY LRDLFDRADG 

       610        620        630        640        650        660 
PAPFVDLALE KRNGEFVRSA IRNGQVTACH DLSDGGLAIA VAEMAIKSGK GATLDAGDGL 

       670        680        690        700        710        720 
PHALLFGEDQ ARYVISATPE MAKLIALNAE GAGVPFRILG TVGGDRLKIS KNVDVSVADL 

       730        740 
TQAYEGWFPN FMNGELTGNN 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ10813.1.
RefSeqYP_414285.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YNG6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_0857.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ10813; CAJ10813; BAB1_0857.
GeneID3787541.
KEGGbmf:BAB1_0857.
PATRIC17844627. VBIBruMel86222_0892.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0046.
HOGENOMHOG000238227.
KOK01952.
OMAQAVVFKI.
OrthoDBEOG6FNHHR.

Enzyme and pathway databases

BioCycBABO359391:GKDV-871-MONOMER.
BMEL359391:GJOQ-871-MONOMER.
UniPathwayUPA00074; UER00128.

Family and domain databases

Gene3D3.30.1330.10. 2 hits.
HAMAPMF_00420. PurL_2.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR010074. PRibForGlyAmidine_synth_II.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 2 hits.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 2 hits.
TIGRFAMsTIGR01736. FGAM_synth_II. 1 hit.
ProtoNetSearch...

Other

PROQ2YNG6.

Entry information

Entry namePURL_BRUA2
AccessionPrimary (citable) accession number: Q2YNG6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names