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Q2YNE3

- SYP_BRUA2

UniProt

Q2YNE3 - SYP_BRUA2

Protein

Proline--tRNA ligase

Gene

proS

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).UniRule annotation

    Catalytic activityi

    ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. proline-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. prolyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-856-MONOMER.
    BMEL359391:GJOQ-856-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
    Alternative name(s):
    Prolyl-tRNA synthetaseUniRule annotation
    Short name:
    ProRSUniRule annotation
    Gene namesi
    Name:proSUniRule annotation
    Ordered Locus Names:BAB1_0842
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Proline--tRNA ligasePRO_0000248892Add
    BLAST

    Proteomic databases

    PRIDEiQ2YNE3.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_0842.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YNE3.
    SMRiQ2YNE3. Positions 1-439.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0442.
    HOGENOMiHOG000076894.
    KOiK01881.
    OMAiMHQAYCN.
    OrthoDBiEOG6TTVMR.

    Family and domain databases

    Gene3Di3.40.50.800. 1 hit.
    HAMAPiMF_01570. Pro_tRNA_synth_type2.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR002316. Pro-tRNA-ligase_IIa.
    IPR004500. Pro-tRNA-synth_IIa_bac-type.
    IPR023716. Prolyl-tRNA_ligase_IIa_type2.
    [Graphical view]
    PANTHERiPTHR11451:SF3. PTHR11451:SF3. 1 hit.
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view]
    PRINTSiPR01046. TRNASYNTHPRO.
    SUPFAMiSSF52954. SSF52954. 1 hit.
    TIGRFAMsiTIGR00409. proS_fam_II. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YNE3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLSRYFLPI LKENPKEAEI VSHRLMLRSG MIRQQSAGIY SWLPIGLKVL    50
    NKVCTIIREE QNRAGANEIL MPTIQSADLW RESGRYDAYG KEMLRIQDRQ 100
    KREMLFGPTN EEMVTDIFRS YVRSYKDLPL NLYHIQWKFR DEVRPRFGVM 150
    RSREFLMKDA YSFDLDYEGA KMAYYRMFVS YLRTFARVGL QAIPMRADTG 200
    PIGGDLSHEF IILAETGESQ VYCDRAYLDL AVPGADTDFR NDAQLTDIVT 250
    RWTTPYAATD EMHDEADWAK VKPESQVSAR GIEVGHIFHF GTKYSEPMGA 300
    KVQGPDGKEH LVSMGSYGIG PSRLVAAAIE ASHDDAGIIW PKTIAPFGAG 350
    IVNMKPGDEG CDGVSEKLYE ALTNAGVDPL LDDKDERPGA KFATMDLIGL 400
    PTQVIVGPRG VAAGEVEVKD RKTGERQSLG IKAAINMLTA QA 442
    Length:442
    Mass (Da):49,507
    Last modified:February 7, 2006 - v1
    Checksum:iBCED4B480F6E7875
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10798.1.
    RefSeqiYP_414273.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ10798; CAJ10798; BAB1_0842.
    GeneIDi3787527.
    KEGGibmf:BAB1_0842.
    PATRICi17844597. VBIBruMel86222_0877.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10798.1 .
    RefSeqi YP_414273.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YNE3.
    SMRi Q2YNE3. Positions 1-439.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_0842.

    Proteomic databases

    PRIDEi Q2YNE3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ10798 ; CAJ10798 ; BAB1_0842 .
    GeneIDi 3787527.
    KEGGi bmf:BAB1_0842.
    PATRICi 17844597. VBIBruMel86222_0877.

    Phylogenomic databases

    eggNOGi COG0442.
    HOGENOMi HOG000076894.
    KOi K01881.
    OMAi MHQAYCN.
    OrthoDBi EOG6TTVMR.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-856-MONOMER.
    BMEL359391:GJOQ-856-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.800. 1 hit.
    HAMAPi MF_01570. Pro_tRNA_synth_type2.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR002316. Pro-tRNA-ligase_IIa.
    IPR004500. Pro-tRNA-synth_IIa_bac-type.
    IPR023716. Prolyl-tRNA_ligase_IIa_type2.
    [Graphical view ]
    PANTHERi PTHR11451:SF3. PTHR11451:SF3. 1 hit.
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view ]
    PRINTSi PR01046. TRNASYNTHPRO.
    SUPFAMi SSF52954. SSF52954. 1 hit.
    TIGRFAMsi TIGR00409. proS_fam_II. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiSYP_BRUA2
    AccessioniPrimary (citable) accession number: Q2YNE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3