Q2YNB0 (CTAA_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heme A synthase
Short name=HAS
EC=1.3.-.-

Alternative name(s):
Cytochrome aa3-controlling protein

Gene names

Name:	ctaA
Ordered Locus Names:	BAB1_0807

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group By similarity. HAMAP-Rule MF_01665
Pathway	Porphyrin metabolism; heme A biosynthesis; heme A from heme O: step 1/1. HAMAP-Rule MF_01665
Subunit structure	Interacts with CtaB By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01665.
Sequence similarities	Belongs to the COX15/CtaA family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Heme biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	heme a biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	oxidoreductase activity, acting on the CH-CH group of donors Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Heme A synthase HAMAP-Rule MF_01665		PRO_0000349021
Regions
	Transmembrane	25 – 45	21	Helical; Potential
	Transmembrane	111 – 131	21	Helical; Potential
	Transmembrane	141 – 161	21	Helical; Potential
	Transmembrane	176 – 196	21	Helical; Potential
	Transmembrane	210 – 230	21	Helical; Potential
	Transmembrane	269 – 289	21	Helical; Potential
	Transmembrane	304 – 324	21	Helical; Potential
	Transmembrane	326 – 346	21	Helical; Potential
Sites
	Binding site	334	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YNB0 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 4DF7F2FBFAF09798	FASTA	358	40,048
	10 20 30 40 50 60 MAATSAQHIG LQGHGTSRND RDRRLVRYWL YAVFAVLIAI VMVGGATRMT GSGLSITEWK 70 80 90 100 110 120 PIHGVIPPLN HAEWVEEFEK YQQIPQYQQI NKGMSLAEFQ YIFWWEWAHR LLARFVGFLV 130 140 150 160 170 180 AVPLGFFWLT GRLKGGLKYR MLGLLALGGL QGAIGWWMVA SGLSELTSVS QYRLAIHLTT 190 200 210 220 230 240 ACVIITAVFY IARGLVTYSE RPAERSIQRF AGWIVFAVLV QIYLGGLVAG LHAGLTYNTW 250 260 270 280 290 300 PLMDGAIIPS DLFTQAPWWR NLFENPKTVQ FVHRMFAYTV LLLAILHAVQ VWKNAPGTTH 310 320 330 340 350 ARRTIVLVGL VFIQAMIGIA TLLMSAPLHL GLTHQFFALV VLAFAVAHWR ATKGAYAA

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040264 Genomic DNA. Translation: CAJ10763.1.
RefSeq	YP_414240.1. NC_007618.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB1_0807.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ10763; CAJ10763; BAB1_0807.
GeneID	3787503.
KEGG	bmf:BAB1_0807.
PATRIC	17844521. VBIBruMel86222_0841.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1612.
HOGENOM	HOG000214943.
KO	K02259.
OMA	KTIFWWE.
ProtClustDB	CLSK2754107.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-819-MONOMER.
UniPathway	UPA00269; UER00713.
Family and domain databases
HAMAP	MF_01665. HemeA_synth_type2.
InterPro	IPR003780. HemeA_syn. IPR023754. HemeA_Synthase_type2. [Graphical view]
Pfam	PF02628. COX15-CtaA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CTAA_BRUA2

Accession

Primary (citable) accession number: Q2YNB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program