Q2YN94 (NRDR_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcriptional repressor NrdR

Gene names

Name:	nrdR
Ordered Locus Names:	BAB1_0788

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes By similarity. HAMAP-Rule MF_00440
Cofactor	Binds 1 zinc ion By similarity.
Sequence similarities	Belongs to the NrdR family. Contains 1 ATP-cone domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Domain	Zinc-finger
Ligand	ATP-binding DNA-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Transcriptional repressor NrdR HAMAP-Rule MF_00440		PRO_0000230857
Regions
	Domain	49 – 139	91	ATP-cone
	Zinc finger	3 – 34	32	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YN94 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 04CC792029B47D56	FASTA	158	17,933
	10 20 30 40 50 60 MRCPYCQSED TQVKDSRPAE DGAVIRRRRV CSVCGGRFTT FERVQLRDLM VVKKSGRRVP 70 80 90 100 110 120 FDRDKLTRSI EVALRKRDVD SERVERAISG IVRQLESAGE AEVTSDEIGR LAMDALKGID 130 140 150 DIAYIRFASV YRNFSKAVDF HNVIDELTVS ETGDNLET

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040264 Genomic DNA. Translation: CAJ10744.1.
RefSeq	YP_414221.1. NC_007618.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB1_0788.
Proteomic databases
PRIDE	Q2YN94.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ10744; CAJ10744; BAB1_0788.
GeneID	3787489.
KEGG	bmf:BAB1_0788.
PATRIC	17844479. VBIBruMel86222_0821.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1327.
HOGENOM	HOG000097653.
KO	K07738.
OMA	VCHERFT.
ProtClustDB	PRK00464.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-799-MONOMER.
Family and domain databases
HAMAP	MF_00440. NrdR.
InterPro	IPR005144. ATP-cone. IPR003796. RNR_NrdR-like. [Graphical view]
Pfam	PF03477. ATP-cone. 1 hit. [Graphical view]
TIGRFAMs	TIGR00244. TIGR00244. 1 hit.
PROSITE	PS51161. ATP_CONE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NRDR_BRUA2

Accession

Primary (citable) accession number: Q2YN94

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	February 7, 2006
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program