Q2YN35 (UVRC_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UvrABC system protein C
Short name=Protein UvrC

Alternative name(s):
Excinuclease ABC subunit C

Gene names

Name:	uvrC
Ordered Locus Names:	BAB1_0720

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus

Protein attributes

Sequence length	611 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203
Subunit structure	Interacts with UvrB in an incision complex By similarity.
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00203.
Sequence similarities	Belongs to the UvrC family. Contains 1 GIY-YIG domain. Contains 1 UVR domain.

Ontologies

Keywords
Biological process	DNA damage DNA excision DNA repair SOS response
Cellular component	Cytoplasm
Molecular function	Excision nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	SOS response Inferred from electronic annotation. Source: HAMAP nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 611	611	UvrABC system protein C HAMAP-Rule MF_00203		PRO_0000227406
Regions
	Domain	6 – 84	79	GIY-YIG
	Domain	194 – 229	36	UVR

Sequences

	Sequence		Length	Mass (Da)
	Q2YN35 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: EF3566F14836AC50	FASTA	611	68,026
	10 20 30 40 50 60 MKRLPNNPGV YRMFNSDGGV LYVGKARNLK KRVSNYARGI GHSNRITRMI RETVTMEFVV 70 80 90 100 110 120 TRTETEALLL EANLIKRLRP RFNVLMRDDK SFPYILLTGG HRAPGIFKHR GARSRKGDYF 130 140 150 160 170 180 GPFASAGAVG RTINALQRAF LLRTCTDSVF ETRTRPCLLY QIKRCSAPCT YEISDEDYAG 190 200 210 220 230 240 LVAEAKAFLS GKSQSVKDHL AAAMQAASAD LDFEHAAVYR DRLAALSHVQ SHQGINPQTV 250 260 270 280 290 300 EEADVFAIHQ EGGMTCIQVF FFRTGQNWGN RAYFPKADSS LGPAEVLGAF LSQFYDDKPC 310 320 330 340 350 360 PKLVLLSETV EEQSLITEAL STRAGHKVQV SVPQRGEKKE LVQHALTNAR EALGRRLAET 370 380 390 400 410 420 SSQARLLQGL AETFGLPRAP RRIEVYDNSH IMGTNAVGGM IVAGPEGFVK NQYRKFNIRS 430 440 450 460 470 480 TDITPGDDFG MMREVIERRF SRLVKEHGTP AGEVKNPDAF PAWPDVILID GGQGQVGAVR 490 500 510 520 530 540 QILGEMGISD LVTAIGIAKG VDREAGRERF FMEGKQPFTL PPRDPVLYFI QRLRDEAHRF 550 560 570 580 590 600 AIGTHRARRK KEIVRNPLDE IAGIGPTRKR ALLHHFGTAK AVSRAAVEDL MQIDGISEAM 610 ARAIHDHFRD K

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2308.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM040264 Genomic DNA. Translation: CAJ10676.1.
RefSeq	YP_414162.2. NC_007618.1.
3D structure databases
ProteinModelPortal	Q2YN35.
ModBase	Search...
Protein-protein interaction databases
STRING	359391.BAB1_0720.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ10676; CAJ10676; BAB1_0720.
GeneID	3787429.
KEGG	bmf:BAB1_0720.
PATRIC	17844330. VBIBruMel86222_0748.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0322.
HOGENOM	HOG000279961.
KO	K03703.
OMA	QKLFPIR.
ProtClustDB	PRK00558.
Enzyme and pathway databases
BioCyc	BMEL359391:GJOQ-729-MONOMER.
Family and domain databases
Gene3D	3.40.1440.10. 1 hit. 4.10.860.10. 1 hit.
HAMAP	MF_00203. UvrC.
InterPro	IPR027299. GIY-YIG_dom. IPR000305. GIY-YIG_SF. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR010994. RuvA_2-like. IPR001943. UVR_dom. IPR004791. UvrC. IPR001162. UvrC_homol_region. [Graphical view]
Pfam	PF01541. GIY-YIG. 1 hit. PF02151. UVR. 1 hit. PF08459. UvrC_HhH_N. 1 hit. [Graphical view]
SMART	SM00465. GIYc. 1 hit. SM00278. HhH1. 2 hits. [Graphical view]
SUPFAM	SSF47781. RuvA_2_like. 1 hit. SSF46600. UvrB_C. 1 hit. SSF82771. UvrC_N. 1 hit.
TIGRFAMs	TIGR00194. uvrC. 1 hit.
PROSITE	PS50164. GIY_YIG. 1 hit. PS50151. UVR. 1 hit. PS50165. UVRC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UVRC_BRUA2

Accession

Primary (citable) accession number: Q2YN35

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program