Reviewed,
UniProtKB/Swiss-Prot Q2YN11 (RSH_BRUA2)
Last modified
November 24, 2009.
Version 28.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: GTP pyrophosphokinase rsh EC=2.7.6.5 Alternative name(s): ATP:GTP 3'-pyrophosphotransferase (p)ppGpp synthetase | ||||
| Gene names |
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| Organism | Brucella abortus (strain 2308) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 359391 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 750 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Functions as a (p)ppGpp synthetase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in adaptation of Brucella to its intracellular host environment By similarity. |
| Catalytic activity | ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. |
| Sequence similarities | Belongs to the relA/spoT family. Contains 1 ACT domain. Contains 1 HD domain. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding GTP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | guanosine tetraphosphate metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP bindingInferred from electronic annotation. Source: UniProtKB-KW GTP diphosphokinase activityInferred from electronic annotation. Source: EC amino acid bindingInferred from electronic annotation. Source: InterPro kinase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AM040264 Genomic DNA. Translation: CAJ10628.1. | |
| RefSeq | YP_414114.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2YN11. |
Genome annotation databases | |
| GeneID | 3787392. |
| GenomeReviews | Gene locus BAB1_0672 in contig AM040264_GR. |
| KEGG | bmf:BAB1_0672. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q2YN11. |
| OMA | INICNIK |
Enzyme and pathway databases | |
| BioCyc | BMEL359391:BAB1_0672-MON. |
Family and domain databases | |
| InterPro | IPR002912. ACT_bd. IPR012675. b-grasp_ferredoxin-like. IPR003607. Met-dep_phosphohydro_HD. IPR006674. Met-dep_phosphohydro_HD_sub. IPR007685. RelA_SpoT. IPR004811. SpoT_relA. IPR004095. TGS. IPR012676. TGS-like. [Graphical view] |
| Gene3D | G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit. |
| Pfam | PF01842. ACT. 1 hit. PF01966. HD. 1 hit. PF04607. RelA_SpoT. 1 hit. PF02824. TGS. 1 hit. [Graphical view] |
| SMART | SM00471. HDc. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00691. spoT_relA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | RSH_BRUA2 | ||||||||
| Accession | Primary (citable) accession number: Q2YN11 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Brucella abortus strain 2308 Brucella abortus (strain 2308): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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