Reviewed, UniProtKB/Swiss-Prot Q2YMY8 (OMP2A_BRUA2)

Names and origin

Protein names

Recommended name:
    Porin omp2a

Gene names

Name:	omp2a
Ordered Locus Names:	BAB1_0659

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Cell outer membrane; Multi-pass membrane protein By similarity.
Domain	Consists of 16-stranded beta-barrel sheets, with large surface-exposed loops, that form a transmembrane pore at the center of each barrel. The pore is partially ocluded by a peptide loop that folds into the pore lumen By similarity.
Miscellaneous	The pore formed by omp2a is larger than the one formed by omp2b. omp2b pores have optimal permeability to allow growth and protection against harmful compounds. The larger pore formed by omp2a may be advantageous for intracellular growth, when the bacterium is competing with the host cell for nutrients whose concentration is particularly low within the phagosome.
Sequence similarities	Belongs to the alphaproteobacteria porin family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal Transmembrane
Molecular function	Porin
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW pore complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	porin activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 321	299	Porin omp2a		PRO_0000354007

Sequences

	Sequence		Length	Mass (Da)
	Q2YMY8-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 255D624AB464A4A7	FASTA	321	34,535
	10 20 30 40 50 60 MNIKSLLLGS AAALVAASGA QAADAIVAPE PEAVEYVRVC DAYGAGYFYI PGTETCLRVH 70 80 90 100 110 120 GYVRYDVKGG DDVYSGTDRN GWDKGARFAL MFNTNSETEL GTLGTYTQLR FNYTSNNSRH 130 140 150 160 170 180 DGQYGDFSDD RDVADGGVST GKIAYTFTGG NGFSAVIALE QGGEDVDNDY TIDGYMPHVV 190 200 210 220 230 240 GGLKYAGGWG SIAGVVAYDS VIEEWATKVR GDVNITDRFS VWLQGAYSSA ATPNQNYGQW 250 260 270 280 290 300 GGDWAVWGGA KFIAPEKATF NLQAAHDDWG KTAVTANVAY QLVPGFTITP EVSYTKFGGE 310 320 WKDTVAEDNA WGGIVRFQRS F

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM040264 Genomic DNA. Translation: CAJ10615.1.
RefSeq	YP_414101.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YMY8.
Genome annotation databases
GeneID	3787381.
GenomeReviews	Gene locus BAB1_0659 in contig AM040264_GR.
KEGG	bmf:BAB1_0659.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG301020.
OMA	LQFAYIT.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0659-MON.
Family and domain databases
InterPro	IPR003684. Porin_alphabac. [Graphical view]
Pfam	PF02530. Porin_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OMP2A_BRUA2

Accession

Primary (citable) accession number: Q2YMY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	February 7, 2006
Last modified:	December 15, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)