Reviewed, UniProtKB/Swiss-Prot Q2YMY7 (OMP2B_BRUA2)

Names and origin

Protein names

Recommended name:
    Porin omp2b

Gene names

Name:	omp2b
Ordered Locus Names:	BAB1_0660

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane By similarity.
Subunit structure	Homotrimer By similarity.
Subcellular location	Cell outer membrane; Multi-pass membrane protein By similarity.
Domain	Consists of 16-stranded beta-barrel sheets, with large surface-exposed loops, that form a transmembrane pore at the center of each barrel. The pore is partially ocluded by a peptide loop that folds into the pore lumen By similarity.
Miscellaneous	The pore formed by omp2a is larger than the one formed by omp2b. omp2b pores have optimal permeability to allow growth and protection against harmful compounds. The larger pore formed by omp2a may be advantageous for intracellular growth, when the bacterium is competing with the host cell for nutrients whose concentration is particularly low within the phagosome.
Sequence similarities	Belongs to the alphaproteobacteria porin family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal Transmembrane
Molecular function	Porin
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW pore complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	porin activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 362	340	Porin omp2b		PRO_0000354008

Sequences

	Sequence		Length	Mass (Da)
	Q2YMY7-1 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: E4738BF34DB8615C	FASTA	362	38,723
	10 20 30 40 50 60 MNIKSLLLGS AAALVAASGA QAADAIVAPE PEAVEYVRVC DAYGAGYFYI PGTETCLRVH 70 80 90 100 110 120 GYVRYDVKGG DDVYSGTDRN GWDKSARFAL RVSTGSETEL GTLKTFTELR FNYAANNSGV 130 140 150 160 170 180 DGKYGNETSS GTVMEFAYIQ LGGLRVGIDE SEFHTFTGYL GDVINDDVIS AGSYRTGKIS 190 200 210 220 230 240 YTFTGGNGFS AVIALEQGGD NDGGYTGTTN YHIDGYMPDV VGGLKYAGGW GSIAGVVAYD 250 260 270 280 290 300 SVIEEWAAKV RGDVNITDQF SVWLQGAYSS AATPDQNYGQ WGGDWAVWGG LKYQATQKAA 310 320 330 340 350 360 FNLQAAHDDW GKTAVTANVA YELVPGFTVT PEVSYTKFGG EWKNTVAEDN AWGGIVRFQR SF

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM040264 Genomic DNA. Translation: CAJ10616.1. Different initiation.
RefSeq	YP_414102.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YMY7.
Genome annotation databases
GeneID	3788833.
GenomeReviews	Gene locus BAB1_0660 in contig AM040264_GR.
KEGG	bmf:BAB1_0660.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2YMY7.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0660-MON.
Family and domain databases
InterPro	IPR003684. Porin_alphabac. [Graphical view]
Pfam	PF02530. Porin_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OMP2B_BRUA2

Accession

Primary (citable) accession number: Q2YMY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	November 25, 2008
Last modified:	October 13, 2009
This is version 23 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)