Reviewed, UniProtKB/Swiss-Prot Q2YMX6 (DEGP_BRUA2)

Names and origin

Protein names

Recommended name:
    Probable serine protease do-like
    EC=3.4.21.-

Gene names

Name:	degP
Synonyms:	htrA
Ordered Locus Names:	BAB1_0635

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Periplasm Potential.
Sequence similarities	Belongs to the peptidase S1B family. Contains 2 PDZ (DHR) domains.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Repeat Signal
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 513	488	Probable serine protease do-like		PRO_0000093858
Regions
	Domain	300 – 391	92	PDZ 1
	Domain	414 – 500	87	PDZ 2
	Region	125 – 299	175	Serine protease
Sites
	Active site	152	1	Charge relay system Potential
	Active site	182	1	Charge relay system Potential
	Active site	257	1	Charge relay system Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2YMX6-1 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: DE1CEF1959472806	FASTA	513	53,483
	10 20 30 40 50 60 MSRARISNYR KGVAAVALSA ALAGAFVVTG PLGALNEARA EAVHVTPPPQ AGFADLVEKV 70 80 90 100 110 120 RPAVVSVRVK KDVQETSNRG PQFFGPPGFD QLPDGHPLKR FFRDFGMEPR GDSRSDNRRG 130 140 150 160 170 180 KANKPRPGHE RPVAQGSGFV ISEDGYVVTN NHVVSDGDAY TVVLDDGTEL DAKLIGADPR 190 200 210 220 230 240 TDLAVLKINA PKRKFVYVAF GDDNKVRVGD WVVAVGNPFG LGGTVTSGIV SARGRDIGAG 250 260 270 280 290 300 PYDDFIQIDA AVNKGNSGGP AFDLSGEVIG INTAIFSPSG GSVGIAFAIP SSTAKQVVDQ 310 320 330 340 350 360 LIKKGSVERG WIGVQIQPVT KDIAASLGLA EEKGAIVASP QDDGPAAKAG IKAGDVITAV 370 380 390 400 410 420 NGETVQDPRD LARKVANIAP GEKAALTVWR KNKAEEINVT IAAMPNDKGK SGSQSNDNDG 430 440 450 460 470 480 GQGETLDSYG LTVVPSEDGK GVVVTDVDPD SDAADRGIRS GDVIVSVNNQ TVKTAGDINK 490 500 510 AITAAEKSGR KAVLLQLQSN DQSRFVALPI NQE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, characterization and construction of htrA and htrA-like mutants of Brucella abortus and their survival in BALB/c mice." Tatum F.M., Cheville N.F., Morfitt D. Microb. Pathog. 17:23-36(1994) [PubMed: 7861951] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U07352 Genomic DNA. Translation: AAA70164.1. AM040264 Genomic DNA. Translation: CAJ10591.1.
PIR	I40060.
RefSeq	YP_414077.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YMX6.
Genome annotation databases
GeneID	3787360.
GenomeReviews	Gene locus BAB1_0635 in contig AM040264_GR.
KEGG	bmf:BAB1_0635.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG585708.
OMA	TRSTITI.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0635-MON.
Family and domain databases
InterPro	IPR001478. PDZ/DHR/GLGF. IPR011782. Pept_S1C_Do. IPR001254. Peptidase_S1_S6. IPR001940. Peptidase_S1C. IPR009003. Ser/Cys_Pept_Trypsin-like. [Graphical view]
Pfam	PF00595. PDZ. 2 hits. PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00834. PROTEASES2C.
SMART	SM00228. PDZ. 2 hits. [Graphical view]
PROSITE	PS50106. PDZ. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DEGP_BRUA2

Accession

Primary (citable) accession number: Q2YMX6
Secondary accession number(s): P0A3Z6, Q44597, Q57EC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	December 20, 2005
Last modified:	December 15, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)