Reviewed, UniProtKB/Swiss-Prot Q2YMS6 (BETI_BRUA2)

Names and origin

Protein names

Recommended name:
    HTH-type transcriptional regulator betI

Gene names

Name:	betI
Ordered Locus Names:	BAB1_0578

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Repressor involved in choline regulation of the bet genes By similarity.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway. [regulation] HAMAP MF_00768
Sequence similarities	Contains 1 HTH tetR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transcription factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	HTH-type transcriptional regulator betI HAMAP MF_00768		PRO_0000257727
Regions
	Domain	8 – 68	61	HTH tetR-type
	DNA binding	31 – 50	20	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YMS6-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: 4C8AEC3346CA6337	FASTA	198	21,678
	10 20 30 40 50 60 MPKIGMEPLR RRELIDAAIR TIGQRGSLDV TVAQIAHEAG VSPALAHHYF GGKDKLILAT 70 80 90 100 110 120 MRHLLRELGR DLNVAIKQAN TPHERIAAII AVNFSATQFA QETIAAWLTF YVHAQQSDDI 130 140 150 160 170 180 KRLLRIYARR LHSNLVFALE QLTSRARANR IAEGAGAMID GLYIRHALGA DAPDAASAIA 190 LVEDYIAIQL SGQPSAEN

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM040264 Genomic DNA. Translation: CAJ10534.1.
RefSeq	YP_414027.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YMS6.
Genome annotation databases
GeneID	3787304.
GenomeReviews	Gene locus BAB1_0578 in contig AM040264_GR.
KEGG	bmf:BAB1_0578.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2YMS6.
OMA	INHYFGG
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0578-MON.
Family and domain databases
HAMAP	MF_00768. [Tree]
InterPro	IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. IPR001647. Transcr-reg_TetR-like_bac/arc. IPR017757. Transcriptional_repressor_BetI. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00440. TetR_N. 1 hit. [Graphical view]
PRINTS	PR00455. HTHTETR.
TIGRFAMs	TIGR03384. betaine_BetI. 1 hit.
PROSITE	PS01081. HTH_TETR_1. 1 hit. PS50977. HTH_TETR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETI_BRUA2

Accession

Primary (citable) accession number: Q2YMS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	February 7, 2006
Last modified:	November 24, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)