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Reviewed, UniProtKB/Swiss-Prot Q2YMP8 (BETB_BRUA2)

Last modified November 4, 2008. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8
Gene names
Name: betB
Ordered Locus Names: BAB1_0576
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords

   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: HAMAP

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487Betaine aldehyde dehydrogenase
PRO_1000047029

Regions

Nucleotide binding227 – 2326NAD By similarity

Sites

Active site2491 By similarity
Active site2831 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YMP8-1 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: E4B8F2DFC983A654

FASTA48752,035
        10         20         30         40         50         60 
MKAQPKASHF IGGAFVEDKA GKPLPVIYPA TGEEIASLYS ATPGIIEAAY AAALKAQGEW 

        70         80         90        100        110        120 
AALKPVERGR ILRRTAEILR EKNRKLSKLE TLDTGKALQE TLVADAASAA DALEFFGGII 

       130        140        150        160        170        180 
SGFNGEFVEL GGSFAYTRRE ALGICVGIGA WNYPIQIAAW KSAPALAMGN AFIFKPSENT 

       190        200        210        220        230        240 
PLSALALAEA YKEAGLPDGL FNVVQGYGDV GAALVNHRLT AKVSLTGSVP TGRRIMAQAG 

       250        260        270        280        290        300 
EQLKHVTMEL GGKSPLIVFD DADLESAIGG AMLGNFYSTG QVCSNGTRVF VHKNIRERFI 

       310        320        330        340        350        360 
ERLVERTRKI RIGDPFDEAT QMGPLISAAQ RDKVLSYIKK GKAEGATLAC GGGVPKLQGF 

       370        380        390        400        410        420 
DKGFFIEPTV FADVTDTMTI AREEIFGPVM SVLEFSDEDE VIARANDSEF GLAAGVFTAD 

       430        440        450        460        470        480 
LSRGHHVIGQ IKAGTCWINA YNLTPVEVPF GGYKQSGIGR ENGIAALAHY SQIKTVYVEM 


GKVDSPY 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

AM040264 Genomic DNA. Translation: CAJ10532.1.
RefSeqYP_414025.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3787302.
GenomeReviewsGene locus BAB1_0576 in contig AM040264_GR.
KEGGbmf:BAB1_0576.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ2YMP8.

Enzyme and pathway databases

BioCycBMEL359391:BAB1_0576-MON.

Family and domain databases

HAMAPMF_00804.
[Tree]
InterProIPR016160. Ald_DHase_CS.
IPR016162. Ald_DHase_N.
IPR015590. Aldehyde_DHase.
IPR011264. Betaine_Ald_DHase.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_BRUA2
AccessionPrimary (citable) accession number: Q2YMP8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: November 4, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents