Reviewed, UniProtKB/Swiss-Prot Q2YMJ2 (KGUA_BRUA2)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	BAB1_0489

Organism

Brucella abortus (strain 2308) [Complete proteome] [HAMAP]

Taxonomic identifier

359391 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Guanylate kinase HAMAP MF_00328		PRO_0000266294
Regions
	Domain	14 – 194	181	Guanylate kinase-like
	Nucleotide binding	21 – 28	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YMJ2-1 [UniParc]. Last modified February 7, 2006. Version 1. Checksum: C21405890D05491F	FASTA	220	25,223
	10 20 30 40 50 60 MAISSVENGV ARRGLMVVIS SPSGAGKSTI ARLLLEDPKM KLSLSISVTT RQRRPSEIDG 70 80 90 100 110 120 VHYHFITIRE FERLRDNDEL IEWAEVHGNF YGTLRETAEI ALADGQDMLF DIDWQGADQL 130 140 150 160 170 180 QAKMPADVVS IFILPPTMRE LQQRLNRRAE DTAEVIETRL QNARFEIQKW VKYDYIVINE 190 200 210 220 DLDRSYAAIK SIINAERLRR DRRPGLFDFV TGLLEEDPGM

References

[1]

"Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM040264 Genomic DNA. Translation: CAJ10445.1.
RefSeq	YP_413949.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YMJ2.
Genome annotation databases
GeneID	3788736.
GenomeReviews	Gene locus BAB1_0489 in contig AM040264_GR.
KEGG	bmf:BAB1_0489.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2YMJ2.
OMA	DIDWQGT.
Enzyme and pathway databases
BioCyc	BMEL359391:BAB1_0489-MON.
Family and domain databases
HAMAP	MF_00328. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_BRUA2

Accession

Primary (citable) accession number: Q2YMJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	February 7, 2006
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)