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Q2YMI4 (KHSE_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homoserine kinase

Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:BAB1_0502
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00301

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00301

Sequence similarities

Belongs to the pseudomonas-type ThrB family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

homoserine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Homoserine kinase HAMAP-Rule MF_00301
PRO_0000300783

Sequences

Sequence LengthMass (Da)Tools
Q2YMI4 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 0503E8758D5F1AFA

FASTA32636,645
        10         20         30         40         50         60 
MAVYTDINEI ELGAFLRHYD IGTLTSYKGI AEGVENSNYL LHTSSGSFIL TLYEKRTNRE 

        70         80         90        100        110        120 
DLPFFLGLMQ HLAKRGLECP QPVVRNDGAM IGQLAGRPAA IVTFLEGMWM RRPTVAHCEA 

       130        140        150        160        170        180 
VGEGLAHMHL AGADFPMRRR NGLTLPDWRP LWNLSRKCAD TVERGLVAET EADLDFLEKN 

       190        200        210        220        230        240 
WPADLPQGVI HADLFPDNAF FLGDRLSGFI DFYFACTDIL AYDVAVCLNA WCFEKDFSYN 

       250        260        270        280        290        300 
RTKGAALLRG YTSVRPLSEA EADALLVLAR GAAVRFMLTR LYDWLTVPAG SFVVKKDPME 

       310        320 
YVRRMRFHRQ IESAAEYGLE MQGVAA 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ10458.1.
RefSeqYP_413957.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YMI4.
SMRQ2YMI4. Positions 5-319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_0502.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ10458; CAJ10458; BAB1_0502.
GeneID3788984.
KEGGbmf:BAB1_0502.
PATRIC17843878. VBIBruMel86222_0524.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2334.
HOGENOMHOG000004810.
KOK02204.
OMANAWCFEP.
OrthoDBEOG6BW4W1.

Enzyme and pathway databases

BioCycBABO359391:GKDV-509-MONOMER.
BMEL359391:GJOQ-509-MONOMER.
UniPathwayUPA00050; UER00064.

Family and domain databases

HAMAPMF_00301. Homoser_kinase_2.
InterProIPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamPF01636. APH. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
TIGRFAMsTIGR00938. thrB_alt. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKHSE_BRUA2
AccessionPrimary (citable) accession number: Q2YMI4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names