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Q2YMI4

- KHSE_BRUA2

UniProt

Q2YMI4 - KHSE_BRUA2

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Protein
Homoserine kinase
Gene
thrB, BAB1_0502
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. homoserine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-509-MONOMER.
BMEL359391:GJOQ-509-MONOMER.
UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinase (EC:2.7.1.39)
Short name:
HK
Short name:
HSK
Gene namesi
Name:thrB
Ordered Locus Names:BAB1_0502
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Homoserine kinaseUniRule annotation
PRO_0000300783Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_0502.

Structurei

3D structure databases

ProteinModelPortaliQ2YMI4.
SMRiQ2YMI4. Positions 5-319.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2334.
HOGENOMiHOG000004810.
KOiK02204.
OMAiNAWCFEP.
OrthoDBiEOG6BW4W1.

Family and domain databases

HAMAPiMF_00301. Homoser_kinase_2.
InterProiIPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00938. thrB_alt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YMI4-1 [UniParc]FASTAAdd to Basket

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MAVYTDINEI ELGAFLRHYD IGTLTSYKGI AEGVENSNYL LHTSSGSFIL    50
TLYEKRTNRE DLPFFLGLMQ HLAKRGLECP QPVVRNDGAM IGQLAGRPAA 100
IVTFLEGMWM RRPTVAHCEA VGEGLAHMHL AGADFPMRRR NGLTLPDWRP 150
LWNLSRKCAD TVERGLVAET EADLDFLEKN WPADLPQGVI HADLFPDNAF 200
FLGDRLSGFI DFYFACTDIL AYDVAVCLNA WCFEKDFSYN RTKGAALLRG 250
YTSVRPLSEA EADALLVLAR GAAVRFMLTR LYDWLTVPAG SFVVKKDPME 300
YVRRMRFHRQ IESAAEYGLE MQGVAA 326
Length:326
Mass (Da):36,645
Last modified:February 7, 2006 - v1
Checksum:i0503E8758D5F1AFA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ10458.1.
RefSeqiYP_413957.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ10458; CAJ10458; BAB1_0502.
GeneIDi3788984.
KEGGibmf:BAB1_0502.
PATRICi17843878. VBIBruMel86222_0524.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ10458.1 .
RefSeqi YP_413957.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YMI4.
SMRi Q2YMI4. Positions 5-319.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_0502.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ10458 ; CAJ10458 ; BAB1_0502 .
GeneIDi 3788984.
KEGGi bmf:BAB1_0502.
PATRICi 17843878. VBIBruMel86222_0524.

Phylogenomic databases

eggNOGi COG2334.
HOGENOMi HOG000004810.
KOi K02204.
OMAi NAWCFEP.
OrthoDBi EOG6BW4W1.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00064 .
BioCyci BABO359391:GKDV-509-MONOMER.
BMEL359391:GJOQ-509-MONOMER.

Family and domain databases

HAMAPi MF_00301. Homoser_kinase_2.
InterProi IPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view ]
Pfami PF01636. APH. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
TIGRFAMsi TIGR00938. thrB_alt. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiKHSE_BRUA2
AccessioniPrimary (citable) accession number: Q2YMI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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