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Reviewed, UniProtKB/Swiss-Prot Q2YMI4 (KHSE_BRUA2)

Last modified February 9, 2010. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39
Gene names
Name: thrB
Ordered Locus Names: BAB1_0502
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301

Sequence similarities

Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processthreonine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

homoserine kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Homoserine kinase HAMAP MF_00301
PRO_0000300783

Sequences

Sequence LengthMass (Da)Tools
Q2YMI4-1 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 0503E8758D5F1AFA

FASTA32636,645
        10         20         30         40         50         60 
MAVYTDINEI ELGAFLRHYD IGTLTSYKGI AEGVENSNYL LHTSSGSFIL TLYEKRTNRE 

        70         80         90        100        110        120 
DLPFFLGLMQ HLAKRGLECP QPVVRNDGAM IGQLAGRPAA IVTFLEGMWM RRPTVAHCEA 

       130        140        150        160        170        180 
VGEGLAHMHL AGADFPMRRR NGLTLPDWRP LWNLSRKCAD TVERGLVAET EADLDFLEKN 

       190        200        210        220        230        240 
WPADLPQGVI HADLFPDNAF FLGDRLSGFI DFYFACTDIL AYDVAVCLNA WCFEKDFSYN 

       250        260        270        280        290        300 
RTKGAALLRG YTSVRPLSEA EADALLVLAR GAAVRFMLTR LYDWLTVPAG SFVVKKDPME 

       310        320 
YVRRMRFHRQ IESAAEYGLE MQGVAA 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ10458.1.
RefSeqYP_413957.1.

3D structure databases

SMRQ2YMI4. Positions 5-319.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2YMI4.

Genome annotation databases

GeneID3788984.
GenomeReviewsGene locus BAB1_0502 in contig AM040264_GR.
KEGGbmf:BAB1_0502.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2334.
HOGENOMHBG309377.
OMAADLFRDN.

Enzyme and pathway databases

BioCycBMEL359391:BAB1_0502-MONOMER.

Family and domain databases

HAMAPMF_00301. Homoser_kinase_2.
[Tree]
InterProIPR002575. APH_trans.
IPR005280. Homoserine_Kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamPF01636. APH. 1 hit.
[Graphical view]
TIGRFAMsTIGR00938. thrB_alt. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKHSE_BRUA2
AccessionPrimary (citable) accession number: Q2YMI4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 7, 2006
Last modified: February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents