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Protein

Homoserine kinase

Gene

thrB

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathway: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (BAB1_1293)
  4. Homoserine kinase (thrB)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-509-MONOMER.
BMEL359391:GJOQ-509-MONOMER.
UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:BAB1_0502
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Homoserine kinasePRO_0000300783Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2YMI4.
SMRiQ2YMI4. Positions 5-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudomonas-type ThrB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2334.
HOGENOMiHOG000004810.
KOiK02204.
OMAiAGALRFW.
OrthoDBiEOG6BW4W1.

Family and domain databases

HAMAPiMF_00301. Homoser_kinase_2.
InterProiIPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00938. thrB_alt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YMI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVYTDINEI ELGAFLRHYD IGTLTSYKGI AEGVENSNYL LHTSSGSFIL
60 70 80 90 100
TLYEKRTNRE DLPFFLGLMQ HLAKRGLECP QPVVRNDGAM IGQLAGRPAA
110 120 130 140 150
IVTFLEGMWM RRPTVAHCEA VGEGLAHMHL AGADFPMRRR NGLTLPDWRP
160 170 180 190 200
LWNLSRKCAD TVERGLVAET EADLDFLEKN WPADLPQGVI HADLFPDNAF
210 220 230 240 250
FLGDRLSGFI DFYFACTDIL AYDVAVCLNA WCFEKDFSYN RTKGAALLRG
260 270 280 290 300
YTSVRPLSEA EADALLVLAR GAAVRFMLTR LYDWLTVPAG SFVVKKDPME
310 320
YVRRMRFHRQ IESAAEYGLE MQGVAA
Length:326
Mass (Da):36,645
Last modified:February 7, 2006 - v1
Checksum:i0503E8758D5F1AFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ10458.1.
RefSeqiWP_002963634.1. NZ_KN046823.1.
YP_413957.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ10458; CAJ10458; BAB1_0502.
GeneIDi3788984.
KEGGibmf:BAB1_0502.
PATRICi17843878. VBIBruMel86222_0524.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ10458.1.
RefSeqiWP_002963634.1. NZ_KN046823.1.
YP_413957.1. NC_007618.1.

3D structure databases

ProteinModelPortaliQ2YMI4.
SMRiQ2YMI4. Positions 5-319.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ10458; CAJ10458; BAB1_0502.
GeneIDi3788984.
KEGGibmf:BAB1_0502.
PATRICi17843878. VBIBruMel86222_0524.

Phylogenomic databases

eggNOGiCOG2334.
HOGENOMiHOG000004810.
KOiK02204.
OMAiAGALRFW.
OrthoDBiEOG6BW4W1.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.
BioCyciBABO359391:GKDV-509-MONOMER.
BMEL359391:GJOQ-509-MONOMER.

Family and domain databases

HAMAPiMF_00301. Homoser_kinase_2.
InterProiIPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00938. thrB_alt. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiKHSE_BRUA2
AccessioniPrimary (citable) accession number: Q2YMI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 7, 2006
Last modified: June 24, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.