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Q2YMI4

- KHSE_BRUA2

UniProt

Q2YMI4 - KHSE_BRUA2

Protein

Homoserine kinase

Gene

thrB

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. homoserine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-509-MONOMER.
    BMEL359391:GJOQ-509-MONOMER.
    UniPathwayiUPA00050; UER00064.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
    Short name:
    HKUniRule annotation
    Short name:
    HSKUniRule annotation
    Gene namesi
    Name:thrBUniRule annotation
    Ordered Locus Names:BAB1_0502
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Homoserine kinasePRO_0000300783Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB1_0502.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YMI4.
    SMRiQ2YMI4. Positions 5-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pseudomonas-type ThrB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2334.
    HOGENOMiHOG000004810.
    KOiK02204.
    OMAiNAWCFEP.
    OrthoDBiEOG6BW4W1.

    Family and domain databases

    HAMAPiMF_00301. Homoser_kinase_2.
    InterProiIPR002575. Aminoglycoside_PTrfase.
    IPR005280. Homoserine_kinase_ThrB.
    IPR011009. Kinase-like_dom.
    [Graphical view]
    PfamiPF01636. APH. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    TIGRFAMsiTIGR00938. thrB_alt. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YMI4-1 [UniParc]FASTAAdd to Basket

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    MAVYTDINEI ELGAFLRHYD IGTLTSYKGI AEGVENSNYL LHTSSGSFIL    50
    TLYEKRTNRE DLPFFLGLMQ HLAKRGLECP QPVVRNDGAM IGQLAGRPAA 100
    IVTFLEGMWM RRPTVAHCEA VGEGLAHMHL AGADFPMRRR NGLTLPDWRP 150
    LWNLSRKCAD TVERGLVAET EADLDFLEKN WPADLPQGVI HADLFPDNAF 200
    FLGDRLSGFI DFYFACTDIL AYDVAVCLNA WCFEKDFSYN RTKGAALLRG 250
    YTSVRPLSEA EADALLVLAR GAAVRFMLTR LYDWLTVPAG SFVVKKDPME 300
    YVRRMRFHRQ IESAAEYGLE MQGVAA 326
    Length:326
    Mass (Da):36,645
    Last modified:February 7, 2006 - v1
    Checksum:i0503E8758D5F1AFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10458.1.
    RefSeqiYP_413957.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ10458; CAJ10458; BAB1_0502.
    GeneIDi3788984.
    KEGGibmf:BAB1_0502.
    PATRICi17843878. VBIBruMel86222_0524.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10458.1 .
    RefSeqi YP_413957.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YMI4.
    SMRi Q2YMI4. Positions 5-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_0502.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ10458 ; CAJ10458 ; BAB1_0502 .
    GeneIDi 3788984.
    KEGGi bmf:BAB1_0502.
    PATRICi 17843878. VBIBruMel86222_0524.

    Phylogenomic databases

    eggNOGi COG2334.
    HOGENOMi HOG000004810.
    KOi K02204.
    OMAi NAWCFEP.
    OrthoDBi EOG6BW4W1.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00064 .
    BioCyci BABO359391:GKDV-509-MONOMER.
    BMEL359391:GJOQ-509-MONOMER.

    Family and domain databases

    HAMAPi MF_00301. Homoser_kinase_2.
    InterProi IPR002575. Aminoglycoside_PTrfase.
    IPR005280. Homoserine_kinase_ThrB.
    IPR011009. Kinase-like_dom.
    [Graphical view ]
    Pfami PF01636. APH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    TIGRFAMsi TIGR00938. thrB_alt. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiKHSE_BRUA2
    AccessioniPrimary (citable) accession number: Q2YMI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3