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Protein

Glycine--tRNA ligase alpha subunit

Gene

glyQ

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glycine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-438-MONOMER.
BMEL359391:GJOQ-438-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine--tRNA ligase alpha subunitUniRule annotation (EC:6.1.1.14UniRule annotation)
Alternative name(s):
Glycyl-tRNA synthetase alpha subunitUniRule annotation
Short name:
GlyRSUniRule annotation
Gene namesi
Name:glyQUniRule annotation
Ordered Locus Names:BAB1_0431
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Glycine--tRNA ligase alpha subunitPRO_1000047402Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB1_0431.

Structurei

3D structure databases

ProteinModelPortaliQ2YME4.
SMRiQ2YME4. Positions 6-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0752.
HOGENOMiHOG000264291.
KOiK01878.
OMAiCVILQPY.
OrthoDBiEOG661H9S.

Family and domain databases

HAMAPiMF_00254. Gly_tRNA_synth_alpha.
InterProiIPR006194. Gly-tRNA-synth_heterodimer.
IPR002310. Gly-tRNA_ligase_asu.
[Graphical view]
PfamiPF02091. tRNA-synt_2e. 1 hit.
[Graphical view]
PRINTSiPR01044. TRNASYNTHGA.
TIGRFAMsiTIGR00388. glyQ. 1 hit.
PROSITEiPS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YME4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPTRSFQGL ILTLHNYWAE HGCAILQPYD MEVGAGTFHP ATTLRSLGPK
60 70 80 90 100
PWKAAYVQPS RRPKDGRYGE NPNRLQHYYQ YQVLIKPSPP NLQDLYLGSL
110 120 130 140 150
KAIGLDPTLH DVRFVEDDWE SPTLGAWGLG WECWCDGMEV SQFTYFQQVC
160 170 180 190 200
GIECSPVAGE LTYGLERLAM YVQGVDNVYD LNFNGLEGDE KVTYGDVFLQ
210 220 230 240 250
AEQEYSRYNF EMANTETLHQ HFIDAERECE AILKAGSTGE NSLHKCVFPA
260 270 280 290 300
YDQCIKASHV FNLMDARGVI SVTERQGYIL RVRNLARQCG EAFLLTDAGG

FNFKREGE
Length:308
Mass (Da):34,945
Last modified:February 7, 2006 - v1
Checksum:i6DD60DEDF2F376A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ10387.1.
RefSeqiYP_413891.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ10387; CAJ10387; BAB1_0431.
GeneIDi3787190.
KEGGibmf:BAB1_0431.
PATRICi17843732. VBIBruMel86222_0451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ10387.1.
RefSeqiYP_413891.1. NC_007618.1.

3D structure databases

ProteinModelPortaliQ2YME4.
SMRiQ2YME4. Positions 6-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359391.BAB1_0431.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ10387; CAJ10387; BAB1_0431.
GeneIDi3787190.
KEGGibmf:BAB1_0431.
PATRICi17843732. VBIBruMel86222_0451.

Phylogenomic databases

eggNOGiCOG0752.
HOGENOMiHOG000264291.
KOiK01878.
OMAiCVILQPY.
OrthoDBiEOG661H9S.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-438-MONOMER.
BMEL359391:GJOQ-438-MONOMER.

Family and domain databases

HAMAPiMF_00254. Gly_tRNA_synth_alpha.
InterProiIPR006194. Gly-tRNA-synth_heterodimer.
IPR002310. Gly-tRNA_ligase_asu.
[Graphical view]
PfamiPF02091. tRNA-synt_2e. 1 hit.
[Graphical view]
PRINTSiPR01044. TRNASYNTHGA.
TIGRFAMsiTIGR00388. glyQ. 1 hit.
PROSITEiPS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiSYGA_BRUA2
AccessioniPrimary (citable) accession number: Q2YME4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: February 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.