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Q2YMC3

- RNH2_BRUA2

UniProt

Q2YMC3 - RNH2_BRUA2

Protein

Ribonuclease HII

Gene

rnhB

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

    Cofactori

    Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi38 – 381Divalent metal cationUniRule annotation
    Metal bindingi39 – 391Divalent metal cationUniRule annotation
    Metal bindingi130 – 1301Divalent metal cationUniRule annotation

    GO - Molecular functioni

    1. manganese ion binding Source: UniProtKB-HAMAP
    2. RNA binding Source: InterPro
    3. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. RNA catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-422-MONOMER.
    BMEL359391:GJOQ-422-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
    Short name:
    RNase HIIUniRule annotation
    Gene namesi
    Name:rnhBUniRule annotation
    Ordered Locus Names:BAB1_0415
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Ribonuclease HIIPRO_0000235704Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB1_0415.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YMC3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNase HII family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0164.
    HOGENOMiHOG000100288.
    KOiK03470.
    OMAiAWCIARA.
    OrthoDBiEOG6BKJC8.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    HAMAPiMF_00052_B. RNase_HII_B.
    InterProiIPR022898. RNase_HII.
    IPR001352. RNase_HII/HIII.
    IPR024567. RNase_HII/HIII_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PANTHERiPTHR10954. PTHR10954. 1 hit.
    PfamiPF01351. RNase_HII. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YMC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRSASDSPL LFDLPLAPDF SQEQQLMKRG LKHIAGIDEA GRGPLAGPVV    50
    AAAVVLDQND LPEGLDDSKR LTAARREALY EIILTKAITV SVASLSARSI 100
    DASDIRKAAL EAMRRAVIGL TLKPCHALVD GRDVPPGLPC PGSALVKGDQ 150
    RSVSIAAASI VAKVTRDRMM IRAGAAHPPY GLEIHAGYAT QKHRAAIESE 200
    GPVPGLHRYT FAPIKGCFDC 220
    Length:220
    Mass (Da):23,332
    Last modified:December 20, 2005 - v1
    Checksum:i87E3AB1CD4844E8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10371.1.
    RefSeqiWP_002963547.1. NC_007618.1.
    YP_413875.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ10371; CAJ10371; BAB1_0415.
    GeneIDi3788907.
    KEGGibmf:BAB1_0415.
    PATRICi17843702. VBIBruMel86222_0436.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10371.1 .
    RefSeqi WP_002963547.1. NC_007618.1.
    YP_413875.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YMC3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_0415.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ10371 ; CAJ10371 ; BAB1_0415 .
    GeneIDi 3788907.
    KEGGi bmf:BAB1_0415.
    PATRICi 17843702. VBIBruMel86222_0436.

    Phylogenomic databases

    eggNOGi COG0164.
    HOGENOMi HOG000100288.
    KOi K03470.
    OMAi AWCIARA.
    OrthoDBi EOG6BKJC8.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-422-MONOMER.
    BMEL359391:GJOQ-422-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    HAMAPi MF_00052_B. RNase_HII_B.
    InterProi IPR022898. RNase_HII.
    IPR001352. RNase_HII/HIII.
    IPR024567. RNase_HII/HIII_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    PANTHERi PTHR10954. PTHR10954. 1 hit.
    Pfami PF01351. RNase_HII. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiRNH2_BRUA2
    AccessioniPrimary (citable) accession number: Q2YMC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3