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Protein

Na(+)/H(+) antiporter NhaA

Gene

nhaA

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Na+/H+ antiporter that extrudes sodium in exchange for external protons.By similarity

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-HAMAP
  2. peptidase activity Source: InterPro
  3. sodium ion transmembrane transporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. regulation of pH Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciBABO359391:GKDV-432-MONOMER.
BMEL359391:GJOQ-432-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)/H(+) antiporter NhaA
Alternative name(s):
Sodium/proton antiporter NhaA
Gene namesi
Name:nhaA
Ordered Locus Names:BAB1_0425
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalSequence AnalysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence AnalysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence AnalysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence AnalysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence AnalysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST
Transmembranei265 – 28521HelicalSequence AnalysisAdd
BLAST
Transmembranei298 – 31821HelicalSequence AnalysisAdd
BLAST
Transmembranei334 – 35421HelicalSequence AnalysisAdd
BLAST
Transmembranei367 – 38721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736Na(+)/H(+) antiporter NhaAPRO_0000334475Add
BLAST

Proteomic databases

PRIDEiQ2YMB3.

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_0425.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 387387Na(+)/H(+) antiporter NhaAAdd
BLAST
Regioni388 – 736349Peptidase S49Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. [View classification]Curated
In the C-terminal section; belongs to the peptidase S49 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3004.
HOGENOMiHOG000060687.
KOiK03313.
OrthoDBiEOG61VZ7F.

Family and domain databases

Gene3Di1.20.1530.10. 1 hit.
3.90.226.10. 2 hits.
HAMAPiMF_01844. NhaA.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR023171. Na/H_antiporter_dom.
IPR004670. NhaA.
IPR002142. Peptidase_S49.
[Graphical view]
PANTHERiPTHR30341:SF0. PTHR30341:SF0. 1 hit.
PfamiPF06965. Na_H_antiport_1. 1 hit.
PF01343. Peptidase_S49. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.
TIGRFAMsiTIGR00773. NhaA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YMB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSPQSARP VSIMRRFLDS EAAGGITLMA AAALALIVAN SPFAQTYFDA
60 70 80 90 100
LHLYIGPLSL AHWINDALMA IFFLLVGLEI KREMLDGQLA SWPNRMLPGI
110 120 130 140 150
AAAGGVILPA IIFAVLNHDN PAKLRGWAVP SATDIAFALG VLSLLGSRAP
160 170 180 190 200
SSLKVFLATL AILDDLAAVV IIAIFYTAEI SMPYLGAAFI TAAVLFVMNR
210 220 230 240 250
MGVVKLLPYL ISAVILWFFV FNSGVHATVA GVVAALMIPL KPAPGRPDDM
260 270 280 290 300
TSPLHKLEHA LAKPVAFIVV PIFGFANAGI SFKGLEASVL GDTLTLGILL
310 320 330 340 350
GLFLGKQFGV FGAAWLAIKT GLAEKPMGAS WVQLYGVAIL CGIGFTMSIF
360 370 380 390 400
IGLLSFPSDL MQTETKIGVL SGSALSAICG YLLLRAARPD QSAANPLWKA
410 420 430 440 450
DESPEAKNFG RFLCVFHFAS YIASTYCTER LQAASSLLRR SSLEFALPGL
460 470 480 490 500
LKRLIPRRFR AVETEIPVVR LHGAIMTGGT SLRPTLSLAS TAGILEKAFA
510 520 530 540 550
DKHAPAVAIS INSPGGAPVQ SRLIYRRIRD LAVEHQKKVF VFVEDVAASG
560 570 580 590 600
GYMIALAGDE IIADPSSIVG SIGVVSASFG FPELLKKIGV ERRVYTAGSN
610 620 630 640 650
KVTLDPFQPE KAEDIERLKA LQLEIHATFI DMVKERRAGK LGDNPDLFSG
660 670 680 690 700
LFWTGTTAAS LGLIDGLGDM RSFLRKTYGD KVKLKLIQPQ RGLLGRKLPG
710 720 730
IGMDSGSVEP AQIAAHLGDG LLCVAEEKAI WARYGL
Length:736
Mass (Da):78,587
Last modified:May 20, 2008 - v2
Checksum:i7C5E5742B5EC5654
GO

Sequence cautioni

The sequence CAJ10381.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ10381.1. Different initiation.
RefSeqiYP_413885.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ10381; CAJ10381; BAB1_0425.
KEGGibmf:BAB1_0425.
PATRICi17843722. VBIBruMel86222_0446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ10381.1. Different initiation.
RefSeqiYP_413885.1. NC_007618.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359391.BAB1_0425.

Proteomic databases

PRIDEiQ2YMB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ10381; CAJ10381; BAB1_0425.
KEGGibmf:BAB1_0425.
PATRICi17843722. VBIBruMel86222_0446.

Phylogenomic databases

eggNOGiCOG3004.
HOGENOMiHOG000060687.
KOiK03313.
OrthoDBiEOG61VZ7F.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-432-MONOMER.
BMEL359391:GJOQ-432-MONOMER.

Family and domain databases

Gene3Di1.20.1530.10. 1 hit.
3.90.226.10. 2 hits.
HAMAPiMF_01844. NhaA.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR023171. Na/H_antiporter_dom.
IPR004670. NhaA.
IPR002142. Peptidase_S49.
[Graphical view]
PANTHERiPTHR30341:SF0. PTHR30341:SF0. 1 hit.
PfamiPF06965. Na_H_antiport_1. 1 hit.
PF01343. Peptidase_S49. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.
TIGRFAMsiTIGR00773. NhaA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiNHAA_BRUA2
AccessioniPrimary (citable) accession number: Q2YMB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 1, 2015
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.