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Q2YMB3 (NHAA_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Na(+)/H(+) antiporter NhaA
Alternative name(s):
Sodium/proton antiporter NhaA
Gene names
Name:nhaA
Ordered Locus Names:BAB1_0425
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length736 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Na+/H+ antiporter that extrudes sodium in exchange for external protons By similarity. HAMAP-Rule MF_01844

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01844.

Sequence similarities

In the N-terminal section; belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. [View classification]

In the C-terminal section; belongs to the peptidase S49 family.

Sequence caution

The sequence CAJ10381.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 736736Na(+)/H(+) antiporter NhaA HAMAP-Rule MF_01844
PRO_0000334475

Regions

Transmembrane23 – 4321Helical; Potential
Transmembrane58 – 7821Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane155 – 17521Helical; Potential
Transmembrane178 – 19821Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane298 – 31821Helical; Potential
Transmembrane334 – 35421Helical; Potential
Transmembrane367 – 38721Helical; Potential
Region1 – 387387Na(+)/H(+) antiporter NhaA HAMAP-Rule MF_01844
Region388 – 736349Peptidase S49 HAMAP-Rule MF_01844

Sequences

Sequence LengthMass (Da)Tools
Q2YMB3 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: 7C5E5742B5EC5654

FASTA73678,587
        10         20         30         40         50         60 
MNHSPQSARP VSIMRRFLDS EAAGGITLMA AAALALIVAN SPFAQTYFDA LHLYIGPLSL 

        70         80         90        100        110        120 
AHWINDALMA IFFLLVGLEI KREMLDGQLA SWPNRMLPGI AAAGGVILPA IIFAVLNHDN 

       130        140        150        160        170        180 
PAKLRGWAVP SATDIAFALG VLSLLGSRAP SSLKVFLATL AILDDLAAVV IIAIFYTAEI 

       190        200        210        220        230        240 
SMPYLGAAFI TAAVLFVMNR MGVVKLLPYL ISAVILWFFV FNSGVHATVA GVVAALMIPL 

       250        260        270        280        290        300 
KPAPGRPDDM TSPLHKLEHA LAKPVAFIVV PIFGFANAGI SFKGLEASVL GDTLTLGILL 

       310        320        330        340        350        360 
GLFLGKQFGV FGAAWLAIKT GLAEKPMGAS WVQLYGVAIL CGIGFTMSIF IGLLSFPSDL 

       370        380        390        400        410        420 
MQTETKIGVL SGSALSAICG YLLLRAARPD QSAANPLWKA DESPEAKNFG RFLCVFHFAS 

       430        440        450        460        470        480 
YIASTYCTER LQAASSLLRR SSLEFALPGL LKRLIPRRFR AVETEIPVVR LHGAIMTGGT 

       490        500        510        520        530        540 
SLRPTLSLAS TAGILEKAFA DKHAPAVAIS INSPGGAPVQ SRLIYRRIRD LAVEHQKKVF 

       550        560        570        580        590        600 
VFVEDVAASG GYMIALAGDE IIADPSSIVG SIGVVSASFG FPELLKKIGV ERRVYTAGSN 

       610        620        630        640        650        660 
KVTLDPFQPE KAEDIERLKA LQLEIHATFI DMVKERRAGK LGDNPDLFSG LFWTGTTAAS 

       670        680        690        700        710        720 
LGLIDGLGDM RSFLRKTYGD KVKLKLIQPQ RGLLGRKLPG IGMDSGSVEP AQIAAHLGDG 

       730 
LLCVAEEKAI WARYGL 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ10381.1. Different initiation.
RefSeqYP_413885.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YMB3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_0425.

Proteomic databases

PRIDEQ2YMB3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ10381; CAJ10381; BAB1_0425.
GeneID3787184.
KEGGbmf:BAB1_0425.
PATRIC17843722. VBIBruMel86222_0446.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3004.
HOGENOMHOG000060687.
KOK03313.
OrthoDBEOG61VZ7F.
ProtClustDBCLSK383673.

Enzyme and pathway databases

BioCycBABO359391:GKDV-432-MONOMER.
BMEL359391:GJOQ-432-MONOMER.

Family and domain databases

Gene3D1.20.1530.10. 1 hit.
HAMAPMF_01844. NhaA.
InterProIPR023171. Na/H_antiporter_dom.
IPR004670. NhaA.
IPR002142. Peptidase_S49.
[Graphical view]
PfamPF06965. Na_H_antiport_1. 1 hit.
PF01343. Peptidase_S49. 1 hit.
[Graphical view]
TIGRFAMsTIGR00773. NhaA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNHAA_BRUA2
AccessionPrimary (citable) accession number: Q2YMB3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names