Reviewed,
UniProtKB/Swiss-Prot Q2YMB3 (NHAA_BRUA2)
Last modified
November 24, 2009.
Version 23.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Na(+)/H(+) antiporter nhaA Alternative name(s): Sodium/proton antiporter nhaA | ||||
| Gene names |
| ||||
| Organism | Brucella abortus (strain 2308) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 359391 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 736 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Na+/H+ antiporter that extrudes sodium in exchange for external protons By similarity. |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | In the N-terminal section; belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family. [View classification] In the C-terminal section; belongs to the peptidase S49 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Antiport Ion transport Sodium transport Transport |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane |
| Ligand | Sodium |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: InterPro regulation of pHInferred from electronic annotation. Source: InterPro sodium ion transportInferred from electronic annotation. Source: HAMAP |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: HAMAP |
| Molecular function | antiporter activity Inferred from electronic annotation. Source: HAMAP peptidase activityInferred from electronic annotation. Source: InterPro sodium ion bindingInferred from electronic annotation. Source: UniProtKB-KW sodium ion transmembrane transporter activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 736 | 736 | Na(+)/H(+) antiporter nhaA HAMAP MF_01844 | PRO_0000334475 | |||||
Regions | |||||||||
| Transmembrane | 23 – 43 | 21 | Potential | ||||||
| Transmembrane | 58 – 78 | 21 | Potential | ||||||
| Transmembrane | 96 – 116 | 21 | Potential | ||||||
| Transmembrane | 126 – 146 | 21 | Potential | ||||||
| Transmembrane | 155 – 175 | 21 | Potential | ||||||
| Transmembrane | 178 – 198 | 21 | Potential | ||||||
| Transmembrane | 224 – 244 | 21 | Potential | ||||||
| Transmembrane | 265 – 285 | 21 | Potential | ||||||
| Transmembrane | 298 – 318 | 21 | Potential | ||||||
| Transmembrane | 334 – 354 | 21 | Potential | ||||||
| Transmembrane | 367 – 387 | 21 | Potential | ||||||
| Region | 1 – 387 | 387 | Na(+)/H(+) antiporter nhaA HAMAP MF_01844 | ||||||
| Region | 388 – 736 | 349 | Peptidase S49 HAMAP MF_01844 | ||||||
Sequences
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References
| [1] | "Whole-genome analyses of speciation events in pathogenic Brucellae." Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E. Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AM040264 Genomic DNA. Translation: CAJ10381.1. Different initiation. | |
| RefSeq | YP_413885.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2YMB3. |
Genome annotation databases | |
| GeneID | 3787184. |
| GenomeReviews | Gene locus BAB1_0425 in contig AM040264_GR. |
| KEGG | bmf:BAB1_0425. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q2YMB3. |
Enzyme and pathway databases | |
| BioCyc | BMEL359391:BAB1_0425-MON. |
Family and domain databases | |
| HAMAP | MF_01844. Fused. [Tree] |
| InterPro | IPR004670. NhaA. IPR002142. Peptidase_S49. [Graphical view] |
| Pfam | PF06965. Na_H_antiport_1. 1 hit. PF01343. Peptidase_S49. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00773. NhaA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | NHAA_BRUA2 | ||||||||
| Accession | Primary (citable) accession number: Q2YMB3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Brucella abortus strain 2308 Brucella abortus (strain 2308): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


