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Q2YMB3

- NHAA_BRUA2

UniProt

Q2YMB3 - NHAA_BRUA2

Protein

Na(+)/H(+) antiporter NhaA

Gene

nhaA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Na+/H+ antiporter that extrudes sodium in exchange for external protons.By similarity

    GO - Molecular functioni

    1. antiporter activity Source: UniProtKB-HAMAP
    2. peptidase activity Source: InterPro
    3. sodium ion transmembrane transporter activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. regulation of pH Source: InterPro

    Keywords - Biological processi

    Antiport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-432-MONOMER.
    BMEL359391:GJOQ-432-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Na(+)/H(+) antiporter NhaA
    Alternative name(s):
    Sodium/proton antiporter NhaA
    Gene namesi
    Name:nhaA
    Ordered Locus Names:BAB1_0425
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 736736Na(+)/H(+) antiporter NhaAPRO_0000334475Add
    BLAST

    Proteomic databases

    PRIDEiQ2YMB3.

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB1_0425.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YMB3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei334 – 35421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei367 – 38721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 387387Na(+)/H(+) antiporter NhaAAdd
    BLAST
    Regioni388 – 736349Peptidase S49Add
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. [View classification]Curated
    In the C-terminal section; belongs to the peptidase S49 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3004.
    HOGENOMiHOG000060687.
    KOiK03313.
    OrthoDBiEOG61VZ7F.

    Family and domain databases

    Gene3Di1.20.1530.10. 1 hit.
    3.90.226.10. 2 hits.
    HAMAPiMF_01844. NhaA.
    InterProiIPR029045. ClpP/crotonase-like_dom.
    IPR023171. Na/H_antiporter_dom.
    IPR004670. NhaA.
    IPR002142. Peptidase_S49.
    [Graphical view]
    PfamiPF06965. Na_H_antiport_1. 1 hit.
    PF01343. Peptidase_S49. 1 hit.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 2 hits.
    TIGRFAMsiTIGR00773. NhaA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YMB3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNHSPQSARP VSIMRRFLDS EAAGGITLMA AAALALIVAN SPFAQTYFDA    50
    LHLYIGPLSL AHWINDALMA IFFLLVGLEI KREMLDGQLA SWPNRMLPGI 100
    AAAGGVILPA IIFAVLNHDN PAKLRGWAVP SATDIAFALG VLSLLGSRAP 150
    SSLKVFLATL AILDDLAAVV IIAIFYTAEI SMPYLGAAFI TAAVLFVMNR 200
    MGVVKLLPYL ISAVILWFFV FNSGVHATVA GVVAALMIPL KPAPGRPDDM 250
    TSPLHKLEHA LAKPVAFIVV PIFGFANAGI SFKGLEASVL GDTLTLGILL 300
    GLFLGKQFGV FGAAWLAIKT GLAEKPMGAS WVQLYGVAIL CGIGFTMSIF 350
    IGLLSFPSDL MQTETKIGVL SGSALSAICG YLLLRAARPD QSAANPLWKA 400
    DESPEAKNFG RFLCVFHFAS YIASTYCTER LQAASSLLRR SSLEFALPGL 450
    LKRLIPRRFR AVETEIPVVR LHGAIMTGGT SLRPTLSLAS TAGILEKAFA 500
    DKHAPAVAIS INSPGGAPVQ SRLIYRRIRD LAVEHQKKVF VFVEDVAASG 550
    GYMIALAGDE IIADPSSIVG SIGVVSASFG FPELLKKIGV ERRVYTAGSN 600
    KVTLDPFQPE KAEDIERLKA LQLEIHATFI DMVKERRAGK LGDNPDLFSG 650
    LFWTGTTAAS LGLIDGLGDM RSFLRKTYGD KVKLKLIQPQ RGLLGRKLPG 700
    IGMDSGSVEP AQIAAHLGDG LLCVAEEKAI WARYGL 736
    Length:736
    Mass (Da):78,587
    Last modified:May 20, 2008 - v2
    Checksum:i7C5E5742B5EC5654
    GO

    Sequence cautioni

    The sequence CAJ10381.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10381.1. Different initiation.
    RefSeqiYP_413885.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ10381; CAJ10381; BAB1_0425.
    GeneIDi3787184.
    KEGGibmf:BAB1_0425.
    PATRICi17843722. VBIBruMel86222_0446.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ10381.1 . Different initiation.
    RefSeqi YP_413885.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YMB3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_0425.

    Proteomic databases

    PRIDEi Q2YMB3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ10381 ; CAJ10381 ; BAB1_0425 .
    GeneIDi 3787184.
    KEGGi bmf:BAB1_0425.
    PATRICi 17843722. VBIBruMel86222_0446.

    Phylogenomic databases

    eggNOGi COG3004.
    HOGENOMi HOG000060687.
    KOi K03313.
    OrthoDBi EOG61VZ7F.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-432-MONOMER.
    BMEL359391:GJOQ-432-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1530.10. 1 hit.
    3.90.226.10. 2 hits.
    HAMAPi MF_01844. NhaA.
    InterProi IPR029045. ClpP/crotonase-like_dom.
    IPR023171. Na/H_antiporter_dom.
    IPR004670. NhaA.
    IPR002142. Peptidase_S49.
    [Graphical view ]
    Pfami PF06965. Na_H_antiport_1. 1 hit.
    PF01343. Peptidase_S49. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 2 hits.
    TIGRFAMsi TIGR00773. NhaA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiNHAA_BRUA2
    AccessioniPrimary (citable) accession number: Q2YMB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 56 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3