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Q2YMB3

- NHAA_BRUA2

UniProt

Q2YMB3 - NHAA_BRUA2

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Protein
Na(+)/H(+) antiporter NhaA
Gene
nhaA, BAB1_0425
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Na+/H+ antiporter that extrudes sodium in exchange for external protons By similarity.UniRule annotation

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-HAMAP
  2. peptidase activity Source: InterPro
  3. sodium ion transmembrane transporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. regulation of pH Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciBABO359391:GKDV-432-MONOMER.
BMEL359391:GJOQ-432-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)/H(+) antiporter NhaA
Alternative name(s):
Sodium/proton antiporter NhaA
Gene namesi
Name:nhaA
Ordered Locus Names:BAB1_0425
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321Helical; Reviewed prediction
Add
BLAST
Transmembranei58 – 7821Helical; Reviewed prediction
Add
BLAST
Transmembranei96 – 11621Helical; Reviewed prediction
Add
BLAST
Transmembranei126 – 14621Helical; Reviewed prediction
Add
BLAST
Transmembranei155 – 17521Helical; Reviewed prediction
Add
BLAST
Transmembranei178 – 19821Helical; Reviewed prediction
Add
BLAST
Transmembranei224 – 24421Helical; Reviewed prediction
Add
BLAST
Transmembranei265 – 28521Helical; Reviewed prediction
Add
BLAST
Transmembranei298 – 31821Helical; Reviewed prediction
Add
BLAST
Transmembranei334 – 35421Helical; Reviewed prediction
Add
BLAST
Transmembranei367 – 38721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736Na(+)/H(+) antiporter NhaAUniRule annotation
PRO_0000334475Add
BLAST

Proteomic databases

PRIDEiQ2YMB3.

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_0425.

Structurei

3D structure databases

ProteinModelPortaliQ2YMB3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 387387Na(+)/H(+) antiporter NhaAUniRule annotation
Add
BLAST
Regioni388 – 736349Peptidase S49UniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. [View classification]
In the C-terminal section; belongs to the peptidase S49 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3004.
HOGENOMiHOG000060687.
KOiK03313.
OrthoDBiEOG61VZ7F.

Family and domain databases

Gene3Di1.20.1530.10. 1 hit.
3.90.226.10. 2 hits.
HAMAPiMF_01844. NhaA.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR023171. Na/H_antiporter_dom.
IPR004670. NhaA.
IPR002142. Peptidase_S49.
[Graphical view]
PfamiPF06965. Na_H_antiport_1. 1 hit.
PF01343. Peptidase_S49. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.
TIGRFAMsiTIGR00773. NhaA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YMB3-1 [UniParc]FASTAAdd to Basket

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MNHSPQSARP VSIMRRFLDS EAAGGITLMA AAALALIVAN SPFAQTYFDA    50
LHLYIGPLSL AHWINDALMA IFFLLVGLEI KREMLDGQLA SWPNRMLPGI 100
AAAGGVILPA IIFAVLNHDN PAKLRGWAVP SATDIAFALG VLSLLGSRAP 150
SSLKVFLATL AILDDLAAVV IIAIFYTAEI SMPYLGAAFI TAAVLFVMNR 200
MGVVKLLPYL ISAVILWFFV FNSGVHATVA GVVAALMIPL KPAPGRPDDM 250
TSPLHKLEHA LAKPVAFIVV PIFGFANAGI SFKGLEASVL GDTLTLGILL 300
GLFLGKQFGV FGAAWLAIKT GLAEKPMGAS WVQLYGVAIL CGIGFTMSIF 350
IGLLSFPSDL MQTETKIGVL SGSALSAICG YLLLRAARPD QSAANPLWKA 400
DESPEAKNFG RFLCVFHFAS YIASTYCTER LQAASSLLRR SSLEFALPGL 450
LKRLIPRRFR AVETEIPVVR LHGAIMTGGT SLRPTLSLAS TAGILEKAFA 500
DKHAPAVAIS INSPGGAPVQ SRLIYRRIRD LAVEHQKKVF VFVEDVAASG 550
GYMIALAGDE IIADPSSIVG SIGVVSASFG FPELLKKIGV ERRVYTAGSN 600
KVTLDPFQPE KAEDIERLKA LQLEIHATFI DMVKERRAGK LGDNPDLFSG 650
LFWTGTTAAS LGLIDGLGDM RSFLRKTYGD KVKLKLIQPQ RGLLGRKLPG 700
IGMDSGSVEP AQIAAHLGDG LLCVAEEKAI WARYGL 736
Length:736
Mass (Da):78,587
Last modified:May 20, 2008 - v2
Checksum:i7C5E5742B5EC5654
GO

Sequence cautioni

The sequence CAJ10381.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ10381.1. Different initiation.
RefSeqiYP_413885.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ10381; CAJ10381; BAB1_0425.
GeneIDi3787184.
KEGGibmf:BAB1_0425.
PATRICi17843722. VBIBruMel86222_0446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ10381.1 . Different initiation.
RefSeqi YP_413885.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YMB3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_0425.

Proteomic databases

PRIDEi Q2YMB3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ10381 ; CAJ10381 ; BAB1_0425 .
GeneIDi 3787184.
KEGGi bmf:BAB1_0425.
PATRICi 17843722. VBIBruMel86222_0446.

Phylogenomic databases

eggNOGi COG3004.
HOGENOMi HOG000060687.
KOi K03313.
OrthoDBi EOG61VZ7F.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-432-MONOMER.
BMEL359391:GJOQ-432-MONOMER.

Family and domain databases

Gene3Di 1.20.1530.10. 1 hit.
3.90.226.10. 2 hits.
HAMAPi MF_01844. NhaA.
InterProi IPR029045. ClpP/crotonase-like_dom.
IPR023171. Na/H_antiporter_dom.
IPR004670. NhaA.
IPR002142. Peptidase_S49.
[Graphical view ]
Pfami PF06965. Na_H_antiport_1. 1 hit.
PF01343. Peptidase_S49. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 2 hits.
TIGRFAMsi TIGR00773. NhaA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiNHAA_BRUA2
AccessioniPrimary (citable) accession number: Q2YMB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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